Adult T-cell leukemia/lymphoma (ATL) in Bahia, Brazil

Bittencourt, Achiléa Lisboa

doi:10.1590/s1413-86702005000500020

Cited by 9 publications

(5 citation statements)

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“…Quarenta e quatro por cento dos casos de ATL diagnosticados na Bahia têm história de eczema severo na infância, resistente a tratamento e com comprometimento do couro cabeludo, certamente correspondendo a DIH 50 .…”

Section: Evolução E Tratamentounclassified

Manifestations of the human T-cell lymphotropic virus type I infection in childhood and adolescence

Bittencourt¹,

Primo²,

Oliveira³

2006

J Pediatr (Rio J)

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Objectives: To review the literature on diseases linked with infection by human T-cell lymphotropic virus type I (HTLV-I) in childhood and adolescence, with focus on clinical aspects, diagnosis, pathogenesis, progression and treatment.Sources: Medical literature published during the last 20 years identified using PubMed and MEDLINE and from specialized medical books, with emphasis on infective dermatitis associated with HTLV-I (IDH), on the juvenile form of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), on adult T-cell leukemia/lymphoma (ATL) and on HTLV-I-associated uveitis. Keywords used to search databases were: HTLV-I-associated infective dermatitis, HTLV-Iassociated myelopathy/tropical spastic paraparesis, adult T-cell leukemia/lymphoma, HTLV-I-associated uveitis.Summary of the findings: IDH is a chronic, relapsing and infected dermatitis of childhood which always involves the scalp and which may progress to HAM/TSP and ATL. HAM/TSP is a chronic and incapacitating myelopathy of adults. There are 17 well-documented cases of HAM/TSP in children and adolescents in the literature, 12 of whom are patients with IDH. In contrast with the adult form of the disease, the juvenile form is rapid and progressive. ATL is a type of T-cell leukemia/ lymphoma that affects adults and is generally fatal. Eleven of the 24 published reports of ATL in children and adolescents were diagnosed in Brazil.Conclusions: These diseases are likely to be more common in childhood and adolescence than the literature would suggest. It is advisable that serological testing be performed for HTLV-I in children and adolescents suffering from chronic and relapsing eczema, with signs and symptoms of myelopathy or with a diagnosis of T-cell leukemia/lymphoma. It is important that pediatricians know how to recognize the pediatric manifestations of this infection in order to correctly diagnose them and offer their patients appropriate guidance and treatment.

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Section: Evolução E Tratamentounclassified

Manifestations of the human T-cell lymphotropic virus type I infection in childhood and adolescence

Bittencourt¹,

Primo²,

Oliveira³

2006

J Pediatr (Rio J)

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“…There are several types of HTLV-I-induced adult T-cell leukaemia/lymphoma (ATL): acute, lymphomatous, chronic, and smouldering, with a proportion of 55%, 20%, 20% and 5% correspondingly (15). A fifth type of ATL has been described: primary cutaneous tumoral ATL (18). Almost all patients with ATL present with lymphadenopathy and 50% have hepatosplenomegaly.…”

Section: Case Reportmentioning

confidence: 99%

Human T-cell Lymphotrophic Virus (HTLV-1) and Adult T-Cell Leukemia/Lymphoma (ATL) – Case Report and Literature Review

Nwachukwu¹,

Browne²,

Barnard³

et al. 2016

West Indian Med J

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BACKGROUND In the mid-1970s, retroviruses had been discovered in many vertebrate species, including apes. The hypothesis that humans may also be infected with retroviruses led to a search that ultimately resulted in the isolation of a retrovirus from the cell lines and blood of patients with adult T-cell leukemia. This virus is called Human T-cell lymphotropic Virus (HTLV-I). HTLV-I has been linked to a paralytic disease that occurs in the tropics (Caribbean islands) called tropical spastic paraparesis. HTLV-I induced leukemia has also been described in the Caribbean and Japan (1, 2). A second human retrovirus was isolated from T-cells of patients with a T-cell variant of hairy cell leukemia, called HTLV-II, but this virus has no known role in producing disease (3). Modes of HTLV-I transmission routes are similar to those for HIV and include sexual contact, transfusion of infected blood and blood products, and maternal-child (3). HTLV-I is transmitted from infected women to their offspring predominantly via breast milk, with seroconversion occurring in 18-26% of the breastfed offspring (4-6). Herein we present a case of a middle aged female of no significant past medical history, with HTLV-I and lymphoma who presented with constitutional symptoms.

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“…Of the 74 cases of ATL diagnosed in Bahia, Brazil, 44% had a history of severe eczema during early childhood that was likely to be ID. 64 history of ID. Until this study, only 6 cases of HAM/TSP associated with ID had been identified, 17,19,22,46 which indicates a stronger association between these two conditions than previously thought.…”

Section: Progressionmentioning

confidence: 99%

Human T-lymphotrophic virus type 1–associated infective dermatitis: A comprehensive review

Lee

Schwartz

2011

Journal of the American Academy of Dermatology

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Adult T-cell leukemia/lymphoma (ATL) in Bahia, Brazil

Cited by 9 publications

References 0 publications

Manifestations of the human T-cell lymphotropic virus type I infection in childhood and adolescence

Manifestations of the human T-cell lymphotropic virus type I infection in childhood and adolescence

Human T-cell Lymphotrophic Virus (HTLV-1) and Adult T-Cell Leukemia/Lymphoma (ATL) – Case Report and Literature Review

Human T-lymphotrophic virus type 1–associated infective dermatitis: A comprehensive review

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