Evaluation of the secretory immunoglobulin A levels in the colostrum and milk of mothers of term and pre-trerm newborns

Araújo, Edilson Divino de; Gonçalves, Ana Katherine; Cornetta, Maria da Conceição; Cunha, Heleana; Cardoso, Maria Leila; Morais, Sirlei Siani; Giraldo, Paulo César

doi:10.1590/s1413-86702005000500002

Cited by 49 publications

(55 citation statements)

References 15 publications

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“…Reported data on the content ofsecretorysIgAin human milk vary widely; most studies report a mean value on gIL for colostnun and 0.2-0.6 gIL for mature milk (25; and for a review see 26). On the other hand, some authors reported values very similar to those found in this study, with the same steady decrease in the first 4 days oflactation (27)(28)(29)(30).…”

Section: Discussionsupporting

confidence: 89%

Immunoglobulin-A Profile in Breast Milk from Mothers Delivering Full Term and Preterm Infants

Ballabio

Bertino

Coscia

et al. 2007

Int J Immunopathol Pharmacol

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Recent advances in the care of low-birth-weight and preterm neonates have stimulated research into the best dietetic program to improve their survival and short/long term outcome. Some components of human milk that cannot be included in artificial formulas may be critical for survival. Of these, immunoglobulins are important, and in particular secretory immunoglobulins A (sIgA). The concentration of secretory IgA was measured by immunoblotting (an immunoelectrophoretic technique having high specificity and reliability) in milk from mothers delivering at term (TM) or prematurely (PM). In both groups, IgA concentrations were high very early on but quickly decreased during the first week of lactation. The early IgA mean concentration was higher in PM than in TM but, because of high variability in PM milk, the difference rarely reached statistical significance. This variability during lactation reflects the important role of human milk in supplying immunological factors to cope with the gastrointestinal absorption of high molecular weight proteins in the first days of life. Immunological protection is particularly critical for a preterm baby, so it is important to promote feeding with its own mother's milk if possible, paying strict attention to the timing of milk collection. During the lactating period, human milk is the first choice for feeding the newborn, both because of its nutritional profile and its biological characteristics. Among its numerous important modulating activities, breast feeding provides the newborn with important protection against infections (1-5): the newborn has an immature immune system compared to that of an adult subject (6). Several proteins in human milk, most importantly lactoferrin, lysozyme and immunoglobulins, protect against pathogenic bacteria, viruses and fungi (7-8). Of the immunoglobulins found in human milk, the major one is secretory immunoglobulin A (sIgA) (>90%); sIgA is a dimer ofIgA linked to a secretory component by a linking chain (9). Goldman (9) showed that breast feeding allows immunity to be transferred from mother to child, and identified the presence in human milk of specific IgA antibodies against bacterial pathogens (Escherichia coli, Haemophilus influenzae, Streptococcus pneumoniae, Clostridium difficile, Salmonella and Vibrio cholerae), viruses (rotavirus, cytomegalovirus, HIV, influenza virus) and yeasts (Candida albicans). Preterm very-Iow-birthweight infants (VLBWIs) must be given specific nutritional consideration; in the last 10 years advances in neonatology have progressively improved these infants' survival. It is well known that nutritional management is important for immediate survival and subsequent outcome, but because of their limited nutritional reserves and

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Section: Discussionsupporting

confidence: 89%

Immunoglobulin-A Profile in Breast Milk from Mothers Delivering Full Term and Preterm Infants

Ballabio

Bertino

Coscia

et al. 2007

Int J Immunopathol Pharmacol

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“…En cuanto al análisis del calostro de las madres que han tenido un parto prematuro, los niveles de IgAs obtenidos en el calostro recogido en las primeras 72 horas de vida del recién nacido son similares a los datos publicados en la bibliografía (8,9,26).…”

Section: T-student (Calostro/control) *Diferencia Estadisticamente Sunclassified

“…Estas uniones se cierran progresivamente durante los primeros días después del nacimiento, por ello la composición del calostro es tan diferente de la leche madura (7). Recientes estudios han podido demostrar que el calostro de las mujeres que han dado a luz un recién nacido prematuro tiene una concentración más alta de dichos factores defensivos, lo que sugiere que tienen un papel biológico importante en la protección del niño pretérmino, con alto riesgo de infección, durante los primeros días de vida (8)(9)(10). La presencia de estos factores protectores se traduce en una serie de ventajas digestivas (maduración de la mucosa intestinal a través de los factores de crecimiento y hormonas que aporta, dificultando que los agentes patógenos puedan penetrar la pared intestinal) y defensivas (11).…”

Section: Introductionunclassified

Efectos de la administración de calostro orofaríngeo en recién nacidos prematuros sobre los niveles de inmunoglobulina A

Álvarez¹,

Cabanillas²,

Peña‐Caballero³

et al. 2016

Nutr Hosp

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Introducción: el recién nacido prematuro de muy bajo peso (RNMBP) es inmunológicamente inmaduro y además presenta una alteración de las barreras naturales de defensa. Objetivo: evaluar los efectos que pueda tener la administración de calostro orofaríngeo, administrado durante los primeros 15 días posnatales, sobre los niveles de inmunoglobulina A (IgA) sérica en recién nacidos prematuros de muy bajo peso durante el primer mes de vida. Material y métodos: se desarrolló un estudio de intervención no aleatorizado con grupo control, en el que se incluyeron 38 recién nacidos con ≤ 32 + 6 semanas de gestación y/o menores de 1.500 g de peso. Los sujetos recibieron 0,2 ml de calostro de su madre cada 4 h, iniciándose el procedimiento en las primeras 24 h de vida hasta el 15.o día postnatal. Se midieron los niveles de IgA en la sangre al nacimiento, 3. er , 15.o y 30.o días de vida. Se registraron datos perinatales al nacimiento y durante el periodo de seguimiento. Resultados: IgA sérica aumentó de forma estadísticamente significativa en el grupo de intervención (M1 15,84 μg/ml, M2 20,07 μg/ml, M3 23,65 μg/ml, M4 30,34 μg/ml, p 0,001) y en el grupo control (M1 12,48 μg/ml, M2 16,48 μg/ml, p 0,018; M3 19,41 μg/ml, M4 22,48 μg/ml, p 0,001). Al mes de vida, los niveles de IgA sérica fueron significativamente mayores en el grupo de intervención que en el grupo control (p 0,026). Conclusiones: este estudio sugiere que la administración de calostro orofarínge

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“…sIgA는 면역글로블 린 중 모유에 가장 많은 항체로 세균이나 항원의 침입으로부 터 신생아 장관 및 기관지 점막을 보호하며 식세포작용(phagocytosis)을 강화하고 국소적인 면역기능을 조절한다 [11,12]. [11,13].…”

unclassified

“…모유 내 면역물질은 산모의 영양상태, 나이, 감염상태, 산모 의 질병, 신생아의 재태기간과 같은 신체적 요인뿐 아니라 [14], 모유수유에 대한 만족도, 우울 등 정서적 요인에 의해서도 영 향을 받는다 [12,13]. 분만 직후 산모의 신체적, 심리적 스트레 스가 증가함에 따라 모유 내 면역물질에 변화를 가져온다 [15].…”

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Maternal Psychosocial Factors that Affect Breastfeeding Adaptation and Immune Substances in Human Milk

Kim

Jeong

Kim

et al. 2014

Korean J Women Health Nurs

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Purpose: This study was to identify relationships of maternal psychosocial factors including mother's mood state, childcare stress, social support and sleep satisfaction with breastfeeding adaptation and immune substances in breast milk, especially secretory immunoglobulin A (sIgA) and transforming growth factor-beta 2 (TGF-β2). Methods: Data were collected from 84 mothers who delivered full-term infants by natural childbirth. Structured questionnaires and breast milk were collected at 2~4 days and 6 weeks postpartum. Data were analyzed using descriptive statistics, Pearson's correlation, multiple linear regression, and generalized estimating equation (GEE). Results: Scores for the breastfeeding adaptation scale were significantly related with child care stress, mood state and social support. Mother's anger was positively correlated with the level of sIgA in colostrum (p<.01). Immune substances of breastmilk was significantly influenced by time for milk collection (p<.001) and the type of breastfeeding (sIgA, p<.001, p=.003). Regression analysis showed that breastfeeding adaptation could be explained 59.1% by the type of breastfeeding, childcare stress, the Profile of Mood States, emotional support and sleep quality (F=16.67, p<.001). Conclusion:The findings from this study provide important concepts of breastfeeding adaptation program and explanation of psychosocial factors by immune substances in breast milk. Future research, specially, bio-maker research on breast milk should focus on the ways to improve breastfeeding adaptation.

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Evaluation of the secretory immunoglobulin A levels in the colostrum and milk of mothers of term and pre-trerm newborns

Cited by 49 publications

References 15 publications

Immunoglobulin-A Profile in Breast Milk from Mothers Delivering Full Term and Preterm Infants

Immunoglobulin-A Profile in Breast Milk from Mothers Delivering Full Term and Preterm Infants

Efectos de la administración de calostro orofaríngeo en recién nacidos prematuros sobre los niveles de inmunoglobulina A

Maternal Psychosocial Factors that Affect Breastfeeding Adaptation and Immune Substances in Human Milk

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