GBV-C/HGV and HIV-1 coinfection

Maidana, Maria Teresa; Sabino, Éster Cerdeira; Kallas, Esper G.

doi:10.1590/s1413-86702005000200001

Cited by 15 publications

(8 citation statements)

References 34 publications

(39 reference statements)

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“…The case of GBV-C needs to be assessed separately from the other viruses since, the only antibody for which an ELISA assay was available is the neutralising anti-E2, which is essentially mutually exclusive to viral RNA in circulation [Hadlock and Foung, 1998;Karayiannis et al, 1998;Maidana et al, 2005]. In this case, antibody cannot be considered as a background of exposure to the viral agent.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of persistent and latent viruses in untreated patients infected with HIV‐1 from Ghana, West Africa

Compston

Sarkodie

et al. 2009

Journal of Medical Virology

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Only limited epidemiological data, pertaining to the prevalence of common persistent viruses has been reported in Ghana. This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV-1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV-negative blood donors, asymptomatic HIV and symptomatic/AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus-C (GBV-C), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus-8 (HHV-8) and varicella-zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any group. Prevalence of GBV-C plasma viraemia was significantly higher in asymptomatic and symptomatic HIV infection (16.7%) and (16.2%) than in blood donors (4%) P < 0.005. Occult HBV infection was significantly more frequent in symptomatic HIV infection (10.9%) compared to asymptomatic HIV (3.6%) and blood donors (1.6%) P < 0.005. Although there was a high background of EBV viraemia in cellular fractions of blood donors (8.3%), it was significantly higher in asymptomatic (44.6%) and symptomatic HIV (14.6%) P < 0.0001. For CMV, the significantly increased prevalence of viraemia was only observed in the plasma fraction of the symptomatic HIV-1/AIDS patients (7.6%) compared to asymptomatic individuals (1.8%) and blood donors (0.8%) P< or = 0.001. The background seroprevalence in blood donors was high for B19V (> or =64%), HBV (> or =70%), CMV and EBV (> or =90%) and was significantly increased in HIV infections for HBV, CMV, VZV (symptomatic HIV), and HHV-8 (asymptomatic and symptomatic HIV).

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Section: Discussionmentioning

confidence: 99%

Prevalence of persistent and latent viruses in untreated patients infected with HIV‐1 from Ghana, West Africa

Compston

Sarkodie

et al. 2009

Journal of Medical Virology

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“…The other issue that is also controversial is alleged association between the virus and HIV. Although Tillmann et al and others [Tillmann et al, ; Williams et al, ; Jung et al, ; Maidana et al, ; Xiang et al, ; Tillmann et al, ; Xiang et al, ] suggested a favorable outcome in HIV‐infected patients when the HPgV virus is present, however, a number of studies showed that the above favorable evidence was not conclusive and needs more thorough investigation [Descamps et al, ; Ryt‐Hansen et al, ; Zhang et al, ].…”

Section: Introductionmentioning

confidence: 99%

Detection and phylogenetic analysis of human pegivirus (GBV-C) among blood donors and patients infected with hepatitis B virus (HBV) in Qatar

et al. 2015

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Human Pegivirus (HPgV), formerly GB virus-C/Hepatitis G virus (GBV-C/HGV), collectively known as GBV-C, is widely spread and has been reported to be associated with non-A-E hepatitis. To our knowledge, no previous study was conducted about HPgV in Qatar. Thus, the objectives of this study were as follows: (i) to determine the rates of HPgV infection in Qatar among healthy blood donors and HBV-infected patients, and (ii) to determine the most predominant HPgV genotype in Qatar. A total of 714 blood plasma samples from healthy donors (612) and HBV-infected patients (102) were collected. RNA was extracted, reversed transcribed, and then subjected for HPgV detection by two round-nested PCR using primers amplifying a 208 bp of 5'-UTR of the HPgV. For genotyping, the 5'-UTR PCR products (from 25 randomly picked samples) were cloned and sequenced. The overall infection rate of HPgV in Qatar was 13.3%. There was no significant difference (P = 0.41) in the infection rates between healthy donor (13.7%) and in HBV-infected patients (10.7%). Moreover, we did not find any significant association between HPgV infection rates and nationality, sex, or age (P > 0.05). Sequence analysis of 40 5'-UTR PCR amplicons yielded the European genotype 2 as most predominant in Qatar, although other genotypes (5 and 7) were also present. Our results indicate that there is no strong correlation between HPgV infection rate, condition, nationality, age, and sex, and genotype 2 is most predominant in Qatar.

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“…It has been shown in several studies that the natural course of HIV-1 can be modulated by the presence of viral, bacterial, or parasitic co-infections. For example, while tuberculosis infection exacerbates HIV-1 progression to acquired immunodeficiency syndrome (AIDS) [2], GBV-C co-infection seems to exert a beneficial effect, reducing the HIV-1 viral load and thus delaying the progress of AIDS [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

HIV-1 and GBV-C co-infection in Venezuela

Rodríguez

Garzaro

Loureiro

et al. 2014

J Infect Dev Ctries

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Introduction: Co-infection with GB virus C (GBV-C) in patients infected with human immunodeficiency virus 1 (HIV-1) has been associated with prolonged survival. The aim of this study was to evaluate the prevalence of GBV-C infection among HIV-1-infected patients in Venezuela, and to determine the effects of the co-infection on the levels of relevant cytokines. Methodology: Plasma samples were collected from 270 HIV-1-seronegative and 255 HIV-1-seropositive individuals. GBV-C infection was determined by RT-PCR of the NS5 region and genotyped by sequence analysis of the 5´UTR region. HIV-1 strains were characterized by sequence analysis of pol, vif, env, and nef genes. Selected cytokines were evaluated by ELISA. Results: Ninety-seven of 525 (18.5%) plasma samples tested positive for GBV-C RNA. A significantly higher prevalence of GBV-C was found among HIV-1 patients compared to HIV-1-seronegative individuals (67/255, 26% versus 30/270, 11%; p < 0.001). Statistical difference was observed in the viral load between HIV-1+GBV-C+ and HIV-1+GBV-C-(p = 0.014), although no differences in CD4 + cell counts were found between both groups. TNFα concentration was higher in HIV-1

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GBV-C/HGV and HIV-1 coinfection

Cited by 15 publications

References 34 publications

Prevalence of persistent and latent viruses in untreated patients infected with HIV‐1 from Ghana, West Africa

Prevalence of persistent and latent viruses in untreated patients infected with HIV‐1 from Ghana, West Africa

Detection and phylogenetic analysis of human pegivirus (GBV-C) among blood donors and patients infected with hepatitis B virus (HBV) in Qatar

HIV-1 and GBV-C co-infection in Venezuela

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