Hepatitis C: a critical analysis of therapeutic response predictors

Focaccia, Roberto; Siciliano, R.; Santos, Edgar de Bortholi; Boccardo, E.; Conceição, O.J.G.; Barbosa, U.; Galante, V.C.

doi:10.1590/s1413-86702002000200003

Cited by 2 publications

(1 citation statement)

References 73 publications

(71 reference statements)

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“…Several studies have shown that IFN can normalize serum alanine aminotransferase (ALT), improve liver histology and reduce viral load in patients with chronic hepatitis C (CHC). [48]…”

Section: Interferon-related Autoimmune Thyroid Diseasesmentioning

confidence: 99%

Autoimmune thyroid disorders in hepatitis C virus infection: Effect of interferon therapy

Jadali

2013

Indian J Endocr Metab

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The hepatitis C virus infection represents an important public health problem and is associated with various hepatic and extrahepatic manifestations. Symptoms outside of the liver can occur in multiple organ systems, including hematologic, renal, dermatologic, endocrine, and rheumatologic systems. Among these different organ systems, special attention has focused on the endocrine system because it affects almost every organ in the body. Among the endocrine disorders, thyroid problems are the most common and the thyroid is one of the principal target organs for extrahepatic manifestations in HCV infected patients. In addition, research data suggest that interferon treatment may be associated with immune-mediated thyroid lesions. However, case reports suggest that the response of thyroid extrahepatic manifestations to interferon in patients with chronic HCV is greatly different. The objective of this study was to summarize currently available data on thyroid conditions associated with chronic HCV infection. Moreover, we investigate the incidence of the development of immune mediated thyroid disorders during interferon therapy in these patients.

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“…Several studies have shown that IFN can normalize serum alanine aminotransferase (ALT), improve liver histology and reduce viral load in patients with chronic hepatitis C (CHC). [48]…”

Section: Interferon-related Autoimmune Thyroid Diseasesmentioning

confidence: 99%

Autoimmune thyroid disorders in hepatitis C virus infection: Effect of interferon therapy

Jadali

2013

Indian J Endocr Metab

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Comparison of risk factors among blood donors, volunteers and replacement individuals, infected or not by hepatitis C virus

Felippe¹,

Meira²

2009

J. Venom. Anim. Toxins incl. Trop. Dis

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Hepatitis C is transmitted primarily parenterally by contaminated blood and is often associated with: intravenous drug abuse, invasive procedures, blood transfusions, acupuncture, tattooing, and alcohol and tobacco use. This study aimed to quantify and evaluate the risk factors among blood donors, volunteer blood donors and replacement individuals, infected or not by the C virus. The main transmission routes of C virus were identified in 55 men and 25 women (GI) monitored by the Ambulatory Unit of the Department of Tropical Diseases, Botucatu Medical School, and in 24 men and 26 women (GII), all active blood donors at the Bauru State Hospital Transfusional Agency. Both groups were similar in: tobacco and alcohol consumption, sexual behavior, tattooing and illicit drug use. The duration of alcohol and tobacco consumption and blood transfusions in GI were longer, whereas the option for steady partners, condom use, disposable materials and piercings were predominant in GII. In conclusion, the risk factors for hepatitis C demonstrate the necessity of health policies that act on the primary and secondary prevention levels (respectively, reduction of infection incidence and hepatopathy risk).

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Hepatitis C: a critical analysis of therapeutic response predictors

Cited by 2 publications

References 73 publications

Autoimmune thyroid disorders in hepatitis C virus infection: Effect of interferon therapy

Autoimmune thyroid disorders in hepatitis C virus infection: Effect of interferon therapy

Comparison of risk factors among blood donors, volunteers and replacement individuals, infected or not by hepatitis C virus

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