Syphilitic meningitis in HIV-patients with meningeal syndrome: report of two cases and review

Carmo, Ricardo Andrade; Moura, Alexandre Sampaio; Christo, Paulo Pereira; Morandi, Ana Cláudia; Oliveira, Marcelo Silva de

doi:10.1590/s1413-86702001000500007

Cited by 12 publications

(3 citation statements)

References 28 publications

(45 reference statements)

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“…NCL interacts with protein p42IP4/centaurin-alpha 1 in the brains of Alzheimer’s patients that often exhibit depression comorbidity (Reiser and Bernstein, 2004). Likewise, ACTN1 is differentially expressed in the frontal cortex of patients diagnosed with HIV and meningitis (Selvan et al, 2015) and these conditions exhibit depression comorbidity (Carmo et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

Rodriguez-Zas

Southey

et al. 2018

Psychoneuroendocrinology

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Section: Discussionmentioning

confidence: 99%

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

Rodriguez-Zas

Southey

et al. 2018

Psychoneuroendocrinology

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“…However, a variety of presentations can occur. An increased frequency of ophthalmologic alterations as well as accelerated late manifestations of neurosyphilis have been described 4,15 . Two patients with confirmed neurosyphilis presented headache without an associated meningeal syndrome.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro, Brazil

Gutierrez-Galhardo

Valle

Sá

et al. 2005

Rev. Inst. Med. trop. S. Paulo

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A total of 24 patients with syphilis and HIV infection were treated from January 1997 to March 2003 at the Infectious Dermatology Outpatient Clinic of the Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. The caseload consisted of 20 males (83.3%) and four females (16.7%), with a mean age of 38.04 years and mean T CD4+ count of 389.5 cells/mL. Syphilis was diagnosed as secondary in 16 (62.5%) patients, late latent in eight (33.3%), and tertiary in one (4.2%). Manifestations of secondary syphilis were palmar and plantar erythematopapulous cutaneous lesions in nine (37.5%), papulous exanthema in four (16.7%), patchy alopecia in 3 (12.5%) and osteochondritis in one patient (4.2%). Tertiary syphilis was characterized by verrucous lesions. Neurosyphilis was diagnosed in four patients (16.7%), with headache as the only manifestation in two patients. Drugs used in treatment included benzathine penicillin, ceftriaxone, erythromycin, and crystalline penicillin. Cure was achieved in 18 patients (75%). Five patients (20.8%) were retreated, three of whom presented a history of re-exposure. This study confirms the importance of establishing the diagnosis of neurosyphilis in patients with HIV infection, in addition to performing follow-up on treatment for syphilis.

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“…HIV infection, however, may accelerate the clinical progression to symptomatic NS. 126 The general paresis form of NS is the type most commonly associated with psychiatric symptoms. 122 The psychiatric presentation of NS typically begins insidiously, with mood changes including symptoms of mania or depression.…”

Section: Neurosyphilismentioning

confidence: 99%

Neuropsychiatric Aspects of Infectious Diseases

Munjal

Ferrando

Freyberg

2017

Critical Care Clinics

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Syphilitic meningitis in HIV-patients with meningeal syndrome: report of two cases and review

Cited by 12 publications

References 28 publications

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro, Brazil

Neuropsychiatric Aspects of Infectious Diseases

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