In vitro antimicrobial activity of the aminoglycoside arbekacin tested against oxacillin-resistant Staphylococcus aureus isolated in Brazilian hospitals

Abstract

Arbekacin is an aminoglycoside used in Japan for treating infections caused by gentamicin and oxacillin-resistant S. aureus (

Efficacies of Vancomycin, Arbekacin, and GentamicinAlone or in Combination against Methicillin-Resistant Staphylococcus aureus in an In Vitro InfectiveEndocarditisModel

“…However, most of the studies done on the effect of arbekacin were performed on the basis of an in vitro method (4,17,30,33). An in vitro infection model offers the benefits of effectiveness in evaluation of the efficacy of an antibiotic (since the half-life, dose, and interval could be regulated to fit human pharmacokinetics), no difference compared with animal models, and the fact that the study environment could be regulated (8,9,19).…”

“…However, the response to vancomycin is not satisfactory in serious infection, and the number of vancomycin-resistant strains has increased, requiring measures to counter these problems (10,18,21,24,28). Arbekacin is an antibiotic with a high efficacy against gram-positive bacteria, and its MIC was shown to be effective in gentamicin-resistant S. aureus and MRSA so that it is known as one of the antibiotics that could replace vancomycin (4,15,16,31,32,33). Various combinations of aminoglycosides had been tried in clinical strains which were not completely responsive to vancomycin, but the recent trend of increasing prevalence of aminoglycoside resistance makes treatment difficult (14,22).…”

Molecular Insights into Aminoglycoside Action and Resistance

“…Other inhibitors of bacterial cell wall synthesis can also be coadministered with aminoglycosides to treat infections due to bacterial species that are naturally resistant to aminoglycosides because of impaired uptake, including the enterococci. , For the treatment of urinary tract infections, aminoglycosides can be used alone in monotherapy. More recently introduced aminoglycosides, such as amikacin or arbekacin, which are not substrates for a number of aminoglycoside-modifying enzymes , or which retain their antibacterial activity after modification, are used to treat infections due to gentamicin-resistant organisms, including methicillin-resistant Staphylococcus aureus . − Finally, streptomycin is still used in multidrug chemotherapy to treat multidrug-resistant M. tuberculosis . , …”

In-Vitro Studies of Bio-Silver Nanoparticles in Cytotoxicity and Anti- Inflammatory

“…It was observed that free radical scavenged by the sample (standard.Ascorbic acid and tested.Silver nanoparticles) in their unique percentage of inhibition in a concentration dependent manner. Figure 6-7 reveals the reductive capacity of tested samples compared to that of standard [32][33][34][35].…”