Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative meta-analysis

Martin, Olwenn; Shialis, Tassos; Lester, J.N.; Scrimshaw, Mark D.; Boobis, Alan R.; Voulvoulis, Nikolaos

doi:10.1590/s1413-81232008000500024

Cited by 29 publications

(28 citation statements)

References 85 publications

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“…Family history has been associated with a higher risk, with certain genetic mutations likely contributing [3,5]. Other factors that may be associated with cryptorchidism include low birth weight for gestational age, as well as maternal smoking, analgesic use and estrogen (DES) exposure during pregnancy [6-8]. …”

Section: Introductionmentioning

confidence: 99%

Current Management of Undescended Testes

Kurz

Tasian

2016

Curr Treat Options Peds

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Opinion Statement Undescended testes (UDTs) are a relatively common finding in newborn males, especially in those born prematurely. Upon discovering a non-intrascrotal testis, it is important to determine whether the testis is palpable or non-palpable and whether the finding is unilateral or bilateral. Imaging should not be used in this workup, as no current modality has been shown to be adequately sensitive or specific to aid in management decisions. Patients with UDTs diagnosed after 6 months of age should be referred to a specialist for correction so that surgery may be performed within 1 year thereafter. This allows testes to descend spontaneously if they are to do so while facilitating early intervention to decrease the risk of subfertility and testicular malignancy for those patients in whom spontaneous descent does not occur. The surgical approach is often dependent on the location of the testis on physical exam. Most orchiopexies for palpable testes are performed through an inguinal incision, although a scrotal approach can be safely utilized depending on the testis position. Diagnostic laparoscopy is most often used for non-palpable testes, as it not only allows for the identification of an atrophic or absent testicle, but it also provides an opportunity to perform an orchiopexy simultaneously should a viable testis be found. Hormonal therapy is not recommended for treatment of UDTs due to its low success rate, the incidence of secondary re-ascent, and the possible detrimental effects on spermatogenesis. Finally, patients with bilateral non-palpable UDTs require a more extensive preliminary evaluation to rule out congenital adrenal hyperplasia (CAH) and disorders of sexual development (DSD). This involves serum electrolytes, karyotype analysis and hormonal testing including a serum müllerian inhibiting substance (MIS), in order to determine if testicular tissue is present and functional.

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Section: Introductionmentioning

confidence: 99%

Current Management of Undescended Testes

Kurz

Tasian

2016

Curr Treat Options Peds

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“…These compounds have been linked to effects in the aquatic environment such as ovotestes in male fish and a decline in amphibian populations (Petrovic et al, 2002;Sumpter, 1995;Zhang and Zhou, 2005). Martin et al (2007Martin et al ( , 2008 have highlighted concerns that these compounds are affecting human health. Others have suggested that increased exposure to estrogenic compounds is associated with adverse trends in human reproductive health (Kozak et al, 2001;Sharpe and Skakkebaek, 1993;Soto et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Removal of Steroid Estrogens from Wastewater Using Granular Activated Carbon: Comparison between Virgin and Reactivated Carbon

Rowsell¹,

Pang²,

Tsafou³

et al. 2009

Water Environment Research

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This research was set up in response to new European legislation to identify cost‐effective treatment for removal of steroid estrogens from effluent. This study aimed to compare estrogen removal of two types of granular activated carbon: virgin (F400) and reactivated (C401) carbon. Rapid, small‐scale column tests were conducted with a total bed volume of 24.9 cm 3 over three columns, and analysis was carried out using high‐performance liquid chromatography. Results demonstrated that C401 performed more efficiently with greater than or equal to 81% estrogen removal in wastewater compared to F400 which produced greater than or equal to 65% estrogen removal. Estrogen removal can be affected by competitive adsorption from natural organic matter present in wastewater. In addition, the physical properties of each carbon had the potential to influence adsorption differently, thus resulting in the observed varied adsorption capability of the two carbons.

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“…The offspring from these pregnancies were shown to be at risk for several medical conditions, such as vaginal adenocarcinoma and malformation of the testes. [12][13][14][15][16][17] In one large cohort study, the median total dose of DES administered to pregnant mothers ranged from 1625 to 10 424 mg (approximately 23-150 mg kg -1 body weight). 18 Although the detailed mechanisms of its action and its pharmacokinetics are not well understood, DES has been shown to bind to ERs.…”

mentioning

confidence: 99%

Rapid prolactin induction in adult male rats after treatment with diethylstilbestrol

Maeda

Okumura

Yamaguchi

et al. 2019

J Neuroendocrinology

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Diethylstilbestrol (DES) is a synthetic oestrogen known to disrupt the endocrine system and to cause reproductive toxicity mediated via the hypothalamic‐pituitary‐adrenal axis; however, its molecular mechanism of action is poorly understood. In the present study, we found that, after only 1 week of exposure to DES, blood testosterone dramatically decreased and that this decrease was associated with a strong induction of prolactin (PRL). Even with the increase in PRL, the luteinising hormone and follicle‐stimulating hormone mRNAs slightly decreased. Our results show that, after 48 hours of a single dose of DES, there was a six‐fold increase in PRL expression. After exploring the upstream mechanisms, we determined that dopamine, which inhibits PRL secretion in male rats, did not decrease in the pituitary gland of DES‐treated rats, whereas vasoactive intestinal peptide (VIP), which mediates the acute release of PRL, was elevated. Serotonin (5‐HT) increased in the brain of male rats 24 hours after a single DES treatment; however, PRL, VIP or 5‐HT was not induced by DES in female rats. Our results indicate that DES induces the expression of pituitary PRL in male rats by stimulating VIP in the hypothalamus and 5‐HT in the central nervous system.

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Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative meta-analysis

Cited by 29 publications

References 85 publications

Current Management of Undescended Testes

Current Management of Undescended Testes

Removal of Steroid Estrogens from Wastewater Using Granular Activated Carbon: Comparison between Virgin and Reactivated Carbon

Rapid prolactin induction in adult male rats after treatment with diethylstilbestrol

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