Efeitos da laserterapia na regeneração nervosa periférica

Abstract

OBJECTIVE: The influence of dose of low power lasertherapy (AsGaAl, 830 nm) on the regeneration of the fibular nerve of rats after a crush injury was evaluated by means of the functional gait analysis and histomorphometric parameters. METHODS: Controlled crush injury of the right common fibular nerve, immediately followed by increasing doses (G1: no irradiation; G2: simulated; G3: 5 J/cm2; G4: 10 J/cm2; G5: 20 J/cm2) laser irradiation directly on the lesion site for 21 consecutive days. Functional gait analysis was carried out at weekly intervals by measuring the peroneal/fibular functional index (PFI). The animals were killed on the 21st postoperative day for removal of the fibular nerve, which was prepared for the histomorphometric analysis. RESULTS: The PFI progressively increased during the observation period in all groups, without significant differences between them (p>0.05). The transverse nerve area was significantly wider in group 2 than in groups 3 and 4, while fiber density was significantly greater in group 4 than in all remaining groups. CONCLUSION: The low power AsGaAl laser irradiation did not accelerate nerve recovery with any of the doses used. Level of Evidence I, Therapeutic Studies Investigating the Results of Treatment.

Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review

“…PBMT (660 nm) improved functional index, reduced HIF-1a, TNF-a, and IL-1b, elevated VEGF, NGF, and S100, and decreased tissue ischemia and inflammation [47]. Sene et al [48] (830 nm) observed that PBMT did not accelerate nerve recovery and the study by Dias et al [49] when associating PBMT (780 nm) with latex protein also did not find positive results.…”

“…The effects of PBMT on nerve damage were verified in the sciatic nerve in 17 articles [19,30,31,32,33,34,35,36,38,39,41,42,43,44,46,47,49], facial nerve in 3 [3,6,7], fibular nerve in 2 articles [40,48], and vagus nerve [2], accessory nerve [29], alveolar nerve [45], and dorsal root [37] in one article each. Of the 26 articles inserted in this review, it was observed that 14 [19,31,32,37,38,39,40,41,42,44,45,46,48,49] presented compression as nerve damage (crushing) and 11 [2,3,6,7,30,33,34,35,36,43,47] articles evaluated the effects of PBMT on neurotmeses, which is the worst type of nerve injury.…”

“…Of the 26 articles inserted in this review, it was observed that 14 [19,31,32,37,38,39,40,41,42,44,45,46,48,49] presented compression as nerve damage (crushing) and 11 [2,3,6,7,30,33,34,35,36,43,47] articles evaluated the effects of PBMT on neurotmeses, which is the worst type of nerve injury.…”

Low-intensity pulsed ultrasound for regenerating peripheral nerves: potential for penile nerve

“…There are many proposed methods of speeding nerve regeneration, including physical methods (such as electric stimulation, 13 magnetic field stimulation, 14 and laser stimulation 15 ) and biological methods (such as administration of neurotrophic factors, 16 vitamins, 17 and medications 18 ). However, there are some disadvantages to the clinical application of many of these therapies, and their clinical efficacy is unproven in many cases.…”

Criação E Aplicação De Um Sensor De Pressão Para Atenuar Lesões Em Pacientes Acamados

“…laser também tem sido estudado em relação a um possível papel positivo nas alterações da condução do estímulo nervoso, com a demonstração eletrofisiológica da diminuição do tempo de latência e do aumento da velocidade de condução em nervos normais, tanto em animais como em humanos. (09)Sene et al (2013)(25), realizaram um estudo em ratos quanto à regeneração nervosa periférica com o uso da LTBI. Foram utilizados 50 ratos, sendo estes Altanet al(01) também foram realizadas com grupos caso-controle, porém apresentaram resultados contrários aos achados emEbrahimi et al Oz et al tratou 20 pacientes com dor miofascial através da LTBI com laser diodo de 820 nm, 3J/ cm² de energia e 300 mW de potência, duas vezes na semana sendo ao total 10 sessões.…”