Suplementação de vitamina C não acelera o processo de consolidação de fratura da tíbia em ratos

Giordano, Vincenzo; Albuquerque, Rodrigo Pires e; Amaral, Ney Pecegueiro do; Chame, Cristiano Curcio; Souza, Fábio de; Apfel, Mara Ibis Rodrigues

doi:10.1590/s1413-78522012000100001

Cited by 9 publications

(2 citation statements)

References 24 publications

(33 reference statements)

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“…Evidences suggest that Asc can ameliorate xenobiotic-induced toxicity at systemic levels [ 33 ] as well as the bone tissue [ 36 ]. Studies on fracture healing were less conclusive, and although Asc supplementation improved the mechanical resistance of fracture callus in elderly vitamin C genetically deficient rats, no histological or clinical improvements were seen in wild-type animals [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Grbić¹,

Mirić²,

Kisic³

et al. 2014

Mediators of Inflammation

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In bacterial bone infections, excessively formed oxidants may result in local and systemic oxidative stress. Vitamin C is the major extracellular nonenzymatic antioxidant, also implicated in bone cells metabolism and viability. The physiological functions of vitamin C largely depend on its redox status. We sequentially assessed oxidative stress markers, hydroperoxides and malondialdehyde (MDA), total antioxidant activity (AOA), total vitamin C, ascorbic acid (Asc), and oxidized/reduced vitamin C ratio in 137 patients with acute osteomyelitis (OM). Compared to 52 healthy controls, in OM group baseline serum hydroperoxides, MDA and oxidized/reduced vitamin C ratio were higher whilst Asc and AOA were lower (P < 0.05, resp.). On the other side, total vitamin C levels in patients and controls were similar (P > 0.05), thereby suggesting a relative rather than absolute vitamin C deficiency in OM. During the follow-up, oxidative stress markers, AOA, and oxidizedreduced vitamin C ratio were gradually returned to normal, while there was no apparent change of total vitamin C concentrations. Persistently high values of oxidized/reduced vitamin C ratio and serum MDA were found in subacute OM. In conclusion, acute OM was associated with enhanced systemic oxidative stress and the shift of vitamin C redox status towards oxidized forms.

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Section: Discussionmentioning

confidence: 99%

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Grbić¹,

Mirić²,

Kisic³

et al. 2014

Mediators of Inflammation

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show abstract

“…Similar to the previous clinical studies, animal studies also showed conflicting data on the improvement of fracture healing with vitamin C (DePhillipo et al, 2018). Giordano et al found that vitamin C supplementation had no effect on histological features of fracture healing at week 2, 4, and 6 (Giordano et al, 2012). However, Sarisozen et al analyzed fracture repair at week 2 and 3 and saw accelerated fracture repair (Sarisözen et al, 2002).…”

Section: Vitamin Cmentioning

confidence: 99%

Understanding Reactive Oxygen Species in Bone Regeneration: A Glance at Potential Therapeutics and Bioengineering Applications

Sheppard

Barfield

Barton

et al. 2022

Front. Bioeng. Biotechnol.

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Although the complex mechanism by which skeletal tissue heals has been well described, the role of reactive oxygen species (ROS) in skeletal tissue regeneration is less understood. It has been widely recognized that a high level of ROS is cytotoxic and inhibits normal cellular processes. However, with more recent discoveries, it is evident that ROS also play an important, positive role in skeletal tissue repair, specifically fracture healing. Thus, dampening ROS levels can potentially inhibit normal healing. On the same note, pathologically high levels of ROS cause a sharp decline in osteogenesis and promote nonunion in fracture repair. This delicate balance complicates the efforts of therapeutic and engineering approaches that aim to modulate ROS for improved tissue healing. The physiologic role of ROS is dependent on a multitude of factors, and it is important for future efforts to consider these complexities. This review first discusses how ROS influences vital signaling pathways involved in the fracture healing response, including how they affect angiogenesis and osteogenic differentiation. The latter half glances at the current approaches to control ROS for improved skeletal tissue healing, including medicinal approaches, cellular engineering, and enhanced tissue scaffolds. This review aims to provide a nuanced view of the effects of ROS on bone fracture healing which will inspire novel techniques to optimize the redox environment for skeletal tissue regeneration.

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Vitamin C in orthopedic practices: Current concepts, novel ideas, and future perspectives

Oakes

Bolia

Weber

et al. 2021

Journal Orthopaedic Research

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Vitamin C (ascorbic acid), is an important antioxidant that has been applied broadly in the field of orthopaedics. Current research on vitamin C examines the molecule's role in bone and tendon physiology, as well as joint replacement and Postoperative pain. Most laboratory and human studies associate the use of vitamin C with improved bone health and tendon healing. Recent literature moderately supports the use of vitamin C to improve functional outcomes, decreased postoperative pain, and prevent complex regional pain syndrome following orthopaedic procedures. The perioperative use of vitamin C in patients undergoing joint replacement surgery and anterior cruciate ligament reconstruction is still under investigation. Overall, there is need for high-quality human trials to confirm whether vitamin C can potentiate the outcomes of orthopaedic procedures and to determine optimal dosage and means of administration to maximize its proposed benefits. The purpose of this review was to summarize the application of vitamin C in orthopaedic practices and to identify potential areas for future study. K E Y W O R D S bone, orthopedics, pain management, tendons, vitamin C 1 | INTRODUCTION Vitamin C (ascorbic acid), is an important antioxidant and deficiency of this mineral is most often associated with scurvy. 1 Vitamin C is vital to the production of collagen in both bone and connective tissue and it has been associated with improved collagen synthesis and subsequent tendon healing. 2-4 It also neutralizes free radicals, which helps to decrease oxidative stress and inflammation. 5 Vitamin C has also been used as a supplement in orthopaedic patients. 6-8 Vitamin C has been linked to improved bone mineral density as well as decreased risk of bone fracture and osteoporosis. 9-11 Furthermore, there is recent evidence to suggest that vitamin C may have a protective role in osteoarthritis. 12 From a postoperative recovery perspective, vitamin C has been found to reduce the incidence of complex regional pain syndrome (CRPS) and improve functional outcomes. 5,13 However, some of these conclusions on the therapeutic effect of vitamin C continue to be debated. 14 The purpose of this review was to summarize the role of vitamin C in orthopaedic practices and to identify potential areas for future study. 1.1 | Perioperative pain management Postoperative pain exists as a common challenge to orthopaedic surgeons, as it is linked to increased risk of postoperative complications, longer hospital stays, and significant delays in the return to regular function. 15 Opioids, such as morphine, may be prescribed to limit postoperative pain in orthopedic patients; however, there are a multitude of side effects associated with their use

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Suplementação de vitamina C não acelera o processo de consolidação de fratura da tíbia em ratos

Cited by 9 publications

References 24 publications

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Understanding Reactive Oxygen Species in Bone Regeneration: A Glance at Potential Therapeutics and Bioengineering Applications

Vitamin C in orthopedic practices: Current concepts, novel ideas, and future perspectives

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