Tratamento da Osteonecrose da Cabeça Femoral com celulas progenitoras autólogas em anemia falciforme

Daltro, Gildásio; Fortuna, Vitor; Araujo, Marco; Lessa, Paulo Itamar Ferraz; Sobrinho, Uirassú de Assis Batista; Borojević, Radovan

doi:10.1590/s1413-78522008000100004

Cited by 12 publications

(13 citation statements)

References 19 publications

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“…A follow-up in ovine model of ONFH is not possible because the injury induced presents spontaneous resolution. Our data are in accordance to previous studies, which successfully applied the central decompression technique associated with autologous bone marrow cells in humans 17,28 . We also showed that the procedure performed in this study is safe and does not lead to bone fractures or to the appearance of tumors, and that the cells used for treatment are still alive weeks after the procedure.…”

Section: Discussionsupporting

confidence: 93%

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Successful transplant of mesenchymal stem cells in induced osteonecrosis of the ovine femoral head: preliminary results

Feitosa¹,

Fadel²,

Beltrão-Braga³

et al. 2010

Acta Cir. Bras.

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PURPOSE: Evaluate the bone tissue recovery following transplantation of ovine mesenchymal stem cells (MSC) from bone marrow and human immature dental-pulp stem cells (hIDPSC) in ovine model of induced osteonecrosis of femoral head (ONFH). METHODS: Eight sheep were divided in three experimental groups. First group was composed by four animals with ONFH induced by ethanol through central decompression (CD), for control group without any treatment. The second and third group were compose by two animals, six weeks after ONFH induction received transplantation of heterologous ovine MSC (CD + oMSC), and hIDPSC (CD + hIDPSC), respectively. In both experiments the cells were transplanted without application of any type of immunosupression protocol. RESULTS: Our data indicate that both cell types used in experiments were able to proliferate within injured site providing bone tissue recovery. The histological results obtained from CD+hIDPSC suggested that the bone regeneration in such animals was better than that observed in CD animals. CONCLUSION: Mesenchymal stem cell transplant in induced ovine osteonecrosis of femoral head by central decompression technique is safe, and apparently favors bone regeneration of damaged tissues.

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Section: Discussionsupporting

confidence: 93%

“…In Brazil, Daltron et al 28 performed the treatment of ONFH with mononuclear bone marrow cells in sickle cell disease in eight patients. After eigth months, seven of the eight patients reported improvement from symptoms.…”

Section: Discussionmentioning

confidence: 99%

Successful transplant of mesenchymal stem cells in induced osteonecrosis of the ovine femoral head: preliminary results

Feitosa¹,

Fadel²,

Beltrão-Braga³

et al. 2010

Acta Cir. Bras.

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“…These results and that of Daltro et al (14) encouraged us to try stem cell therapy alternative to early THA in young patients. In our study we deviated from the reported procedure of standard core decompression with multiple drill holes and using bone marrow concentrate or BMMC and found our short term results to be better.…”

Section: Discussionmentioning

confidence: 67%

“…Secondly the radiological changes on the MRI showed marked improvement in with the new bone formation and reduction of the avascular area. Two previous studies in SCD patients have reported the results of bone marrow concentrate in 1 patient (8) and 8 patients by Daltro et al (14) used autologous bone-marrow mononuclear cells implantation and found to be safe and suggested an efficacious treatment modality. Even though our patient number was small and we did not attempt to include FICAT III stage, but we did not carry out and decompression, still the results were encouraging.…”

Section: Discussionmentioning

confidence: 99%

Stem Cell Therapy for Avascular Necrosis of Femoral Head in Sickle Cell Disease: Report of 11 Cases and Review of Literature

Sadat-Ali

Azam

Elshabouri

et al. 2017

IJSC

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Background and Objective: Sickle cell disease (SCD) is quite common in eastern Saudi Arabia and Avascular necrosis of femoral head (ANFH) occurs in 30% of the young patients leading to early joint arthroplasty. This study was conducted to assess the benefits of injection of osteoblasts in the avascular lesions of the head of femur. Patients and Methods: A preset technique was used, 10 CC of bone marrow aspiration was performed under local anesthesia and aseptic technique. Osteoblasts were separated from the bone marrow cells. The avascular area was drilled and 10 million osteoblasts were transplanted at the lesion site. Patients were seen in the out patient clinic after two weeks for removal of the suture and addressed the questionnaire and examined for the range of movement. The follow up MRI was performed at 4 months. Results: The average age was 20.2±3.9 years. The mean hemoglobin S was 81.6±4.8 percent. Quality of Life Score for Chronic Hip Disease was assessed and found at 8.6 (1 being the severe limitation and 10 being normal), whereas Harris hip score improved from 41.7±5.1 to 88.93±3.6 (p＜0.001). MRI of pre and post osteoblast implantation showed robust new bone formation and disappearance of the avascular lesions. Conclusions: The short term results were good and we believe the injection of osteoblast in the avascular lesion of head of femur is a less invasive procedure devoid of any untoward complications and merits such treatment in large patient group with longer follow up.

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“…This result confirms the efficacy of the technique. 9-12 The decrease in the volume injected by the Sepax® processing is important in procedures where the introduction of more than 100 ml of aspirate can be impeditive, as is the case of femoral neck necrosis therapy, 21 in the bone repair of smaller patients or smaller size bones. Theoretically, as a disadvantage of this system, we encounter the fact that the injection of red blood cells with subsequent release of iron can be an adverse condition for cell proliferation, as observed in vitro .…”

Section: Discussionmentioning

confidence: 99%

Terapia celular da pseudoartose

et al. 2012

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ObjectiveTo assess the safety and efficiency of cell therapy for pseudarthrosis. Implant of the bone marrow aspirate was compared to mononuclear cells purified extemporaneously using the Sepax® equipment.MethodsSix patients with nonunion of the tibia or femur were treated. Four received a percutaneous infusion of autologous bone marrow aspirated from the iliac crest, and two received autologous bone marrow mononuclear cells separated from the aspirate with the Sepax®. The primary fixation method was unchanged, and the nonunion focus was not exposed. Physical examination and radiographies were performed 2, 4 and 6 months after the treatment by the same physician. After consolidation of the fracture the satisfaction of the patients was estimated using the adapted QALY scale.ResultsNo complications occurred as a result of the referred procedures. Bone consolidation was obtained in all cases within 3 to 24 weeks. The degree of patient satisfaction before and after bone consolidation was assessed, with the average value increasing from two to nine (p=0.0156).ConclusionWe conclude that the proposed method is effective and safe for the treatment of nonunion of long bones regardless of the stabilization method used. Level of Evidence II, Prospective Comparative Study

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Tratamento da Osteonecrose da Cabeça Femoral com celulas progenitoras autólogas em anemia falciforme

Cited by 12 publications

References 19 publications

Successful transplant of mesenchymal stem cells in induced osteonecrosis of the ovine femoral head: preliminary results

Successful transplant of mesenchymal stem cells in induced osteonecrosis of the ovine femoral head: preliminary results

Stem Cell Therapy for Avascular Necrosis of Femoral Head in Sickle Cell Disease: Report of 11 Cases and Review of Literature

Terapia celular da pseudoartose

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