Efeito da heparina sódica e da enoxaparina na consolidação de fratura da tíbia no rato: avaliação clínica e anatomopatológica e biomecânica

Curcelli, Emílio Carlos; Müller, Sérgio Swain; Ueda, Anete Kinumi; Padovani, Carlos Roberto; Maffei, Francisco Humberto de Abreu; Hossne, William Saad

doi:10.1590/s1413-78522005000100003

Cited by 3 publications

(2 citation statements)

References 8 publications

(19 reference statements)

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“…Experimental studies performed by Erden 21 and Curcelli 12 in rats exposed to heparin did not report bleeding. A systematic review comparing LMWH and UFH initially showed fewer bleeding episodes 22 .…”

Section: Resultsmentioning

confidence: 94%

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Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats

Figueiró-Filho

Aydos²,

Senefonte³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of exposure of enoxaparin and unfractionated heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of pregnant healthy Wistar rats. METHODS:Enoxaparin and UFH were administered in prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic doses at 2 mg/kg/day 400UI/Kg/day. The rats were divided into five groups. The number of live and dead foetuses was quantified. The uterine horns were dissected and the presence of early and late reabsorptions (abortions) was determined. A p<0.05 was considered statistically significant. RESULTS:We did not observe statistically significant differences between groups when comparing the average weight of the foetuses and placentas, rate of female VS males, rates of pre-implantation loss (RPL), rates of efficiency implantation (REI), rates of postimplantation loss (RPIL) and rates of foetal viability (RFV). CONCLUSIONS:There was no significant effect on fertility with the use of anticoagulant drugs in pregnant healthy Wistar rats.

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Section: Resultsmentioning

confidence: 94%

“…The enoxaparin and UFH doses were standardised according to human studies previously described in the literature and were adjusted by weight 12,13 . The dilutions were determined for compatibility with the drug administration appropriate for the volume in rats 14 .…”

Section: Fifty-five Healthy Animals Of the Species Rattus Norvegicusmentioning

confidence: 99%

Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats

Figueiró-Filho

Aydos²,

Senefonte³

et al. 2014

Acta Cir. Bras.

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The effect of SDF‐1α on low dose BMP‐2 mediated bone regeneration by release from heparinized mineralized collagen type I matrix scaffolds in a murine critical size bone defect model

Zwingenberger

Langanke

Vater

et al. 2016

J Biomedical Materials Res

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The treatment of critical size bone defects represents a challenge. The growth factor bone morphogenetic protein 2 (BMP-2) is clinically established but has potentially adverse effects when used at high doses. The aim of this study was to evaluate if stromal derived factor-1 alpha (SDF-1α) and BMP-2 released from heparinized mineralized collagen type I matrix (MCM) scaffolds have a cumulative effect on bone regeneration. MCM scaffolds were functionalized with heparin, loaded with BMP-2 and/or SDF-1α and implanted into a murine critical size femoral bone defect (control group, low dose BMP-2 group, low dose BMP-2 + SDF-1α group, and high dose BMP-2 group). After 6 weeks, both the low dose BMP-2 + SDF-1α group (5.8 ± 0.6 mm³, p = 0.0479) and the high dose BMP-2 group (6.5 ± 0.7 mm³, p = 0.008) had a significantly increased regenerated bone volume compared to the control group (4.2 ± 0.5 mm³). There was a higher healing score in the low dose BMP-2 + SDF-1α group (median grade 8; Q1-Q3 7-9; p = 0.0357) than in the low dose BMP-2 group (7; Q1-Q3 5-9) histologically. This study showed that release of BMP-2 and SDF-1α from heparinized MCM scaffolds allows for the reduction of the applied BMP-2 concentration since SDF-1α seems to enhance the osteoinductive potential of BMP-2. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2126-2134, 2016.

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Comparative Bone Regeneration Potential Studies of Collagen, Heparin, and Polydopamine-Coated Multichannelled BCP Granules

2018

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The current study is a comparative assessment of the bone regeneration potentiality of bone substitutes composed of bioactive polymer-coated biphasic calcium phosphate (BCP) granules. The bone substitutes were primarily composed of multichanneled BCP granules, which were coated separately with biochemical polymer coatings, namely collagen, heparin, or polydopamine (PD), using chemical methods. The morphologic features and chemical structure of the granules and surface coatings were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy, respectively. The biological characterizations in terms of cellular interaction with the bone substitutes in vitro (MTT assay and proliferation) and in vivo (bone regeneration efficacy) were performed and compared with uncoated BCP granules. It was found that PD-coated BCP granules were superior to the others with respect to promoting more rapid healing. Therefore, PD multichannel BCP granule system can be used as a promising injectable bone substitute for clinical applications.

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Efeito da heparina sódica e da enoxaparina na consolidação de fratura da tíbia no rato: avaliação clínica e anatomopatológica e biomecânica

Abstract: CONCLUSIONWith the methodology used and the analysis of the results obtained in clinical, histological, and biomechanical evaluations, the present study showed that the administration of enoxaparin and heparin sodium did not interfered in bone consolidation in rats.

Cited by 3 publications

References 8 publications

Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats

Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats

The effect of SDF‐1α on low dose BMP‐2 mediated bone regeneration by release from heparinized mineralized collagen type I matrix scaffolds in a murine critical size bone defect model

Comparative Bone Regeneration Potential Studies of Collagen, Heparin, and Polydopamine-Coated Multichannelled BCP Granules

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