Análise comparativa da avaliação funcional realizada na lesão medular em animais

Molina, Alessandra Iague; Cristante, Alexandre Fogaça; Filho, Tarcísio Eloy Pessoa de Barros

doi:10.1590/s1413-78522004000100007

Cited by 1 publication

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“…Commonly employed methods that use qualitative or semiquantitative scales have low reproducibility and lack accuracy and sensitivity1,2, especially to small responses or differences8–12.…”

Section: Introductionmentioning

confidence: 99%

Analysis of The Sensitivity and Reproducibility Of The Basso, Beattie, Bresnahan (BBB) Scale in Wistar Rats

Filho¹,

Molina²

2008

Clinics

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OBJECTIVETo evaluate the sensitivity and reproducibility of the Basso, Beattie, Bresnahan functional scale in the assessment of the locomotor capacity of rats after spinal cord injury.METHODSThirty male Wistar rats underwent laminectomy and mild, moderate or severe spinal cord contusions using the New York University Weight Drop Impactor. The mice were followed for 28 days, after which time each rat was placed in an 80x80x30 cm3 clear box lined with a blue non-slippery material and stimulated to move. Their movement was video-recorded by three digital cameras operating simultaneously. Identical copies of the edited videos were given to six independent evaluators who were blinded with regards to the degree of injury severity. Each evaluator made a determination of the locomotor capacity of the rats using the Basso, Beattie, Bresnahan functional scale.RESULTSWe determined the sensitivity of the method to differences among the evaluators as well as between the results achieved on the left and right hind paws of rats subjected to either mild, moderate or severe injuries by comparing the functional outcomes and reproducibility using non-parametric correlation tests.CONCLUSIONSThe Basso, Beattie, Bresnahan scale showed high reproducibility and satisfactory sensitivity for identifying mild injuries; satisfactory reproducibility and non-satisfactory sensitivity for moderate injuries; and reduced reproducibility and non-satisfactory sensitivity for severe injuries.

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Section: Introductionmentioning

confidence: 99%

Analysis of The Sensitivity and Reproducibility Of The Basso, Beattie, Bresnahan (BBB) Scale in Wistar Rats

Filho¹,

Molina²

2008

Clinics

View full text Add to dashboard Cite

show abstract

Análise comparativa da avaliação funcional realizada na lesão medular em animais

Abstract: The purpose of the study was the analysis and comparison of locomotor classification scales, without ambiguity, efficient and expanded in order to standardize the final measures in laboratories.

Cited by 1 publication

References 21 publications

Analysis of The Sensitivity and Reproducibility Of The Basso, Beattie, Bresnahan (BBB) Scale in Wistar Rats

Analysis of The Sensitivity and Reproducibility Of The Basso, Beattie, Bresnahan (BBB) Scale in Wistar Rats

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