Heart Rate Variability at rest and after the 6-minute walk test (6MWT) in children with cystic fibrosis

Abstract

| Background: Cystic fibrosis (CF) is a multisystem disease that affects the cardiorespiratory system and the cardiac autonomic control may be altered at rest and after a submaximal exercise. Objective: To assess the cardiac autonomic control by heart rate variability (HRV) analysis before and after a 6-minute walk test (6MWT). Method: Thirteen children diagnosed with Cystic Fibrosis (CFG) aged 12±2.7 years (FEV 1 /FVC: 0.83±0.11, FEV 1 : 71.4±21 %pred) and 12 healthy children (control group-CG) aged 11.4±2.4 years (FEV 1 /FVC: 0.91±0.12, FEV 1 : 91.6±17.4 %pred) were included in the study. HRV was evaluated prior to and immediately after the 6MWT and the heart rate recovery assessed on the first and second minute after test.

Heart Rate Variability in Children with Bronchiolitis Obliterans

“…This ratio was 1.25 in the CF group and 0.49 in the control group in the study by Florêncio, and we obtained an LF/HF ratio of 0.6 in our pilot study (unpublished). In the case 2, we think that the significant difference of LF/HF respect to the case 1 and data reported by Florêncio et al [6], is due to the advanced state of the disease characterized by lower walked distance in 6MWT and lower FEV 1 . This predominance of sympathetic activity may contribute to the pathophysiology of cardiovascular disease and could result from changes in the breathing pattern, high levels of catecholamines or the permanently increased level of work associated with breathing [6].…”

Cystic Fibrosis and the Nervous System

“…[91][92][93] Alterations in smooth muscle contractile responses to cholinergic agonists have also been described, 45,94 as has abnormal heart rate variability. 79,80 Altered autonomic function could contribute to manifestations of CF, including cough, GI motility, and mucus secretion, topics explored in greater detail further on.…”

Sympatho–Vagal Dysfunction in Patients with End-Stage Lung Disease Awaiting Lung Transplantation

“…The respiratory rate was significantly coupled with the HF component of the RR interval, as expressed by RR-RESP HFk 2 values (> 0.5) for all groups (Tables 2 and 3); LTx patients showed higher levels of RESP HF than HC. (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), p = 0.02), a marker of sympathetic modulation, and lower levels of 2LV% (7 (4-13) vs. 11 (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), p = 0.005), a marker of vagal modulation, in comparison to healthy controls ( Figure 1). These observations are consistent with the previous ones, confirming a higher sympathetic modulation and a lower vagal modulation in patients with end-stage lung disease.…”