Musculoskeletal pain, profile and quality of life of individuals with sickle cell disease

Ohara, Daniela Gonçalves; Ruas, Gualberto; Castro, Shamyr Sulyvan de; Martins, Paulo Roberto Juliano; Walsh, Isabel Aparecida Porcatti de

doi:10.1590/s1413-35552012005000043

Cited by 19 publications

(30 citation statements)

References 25 publications

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“…and adult patients [19,20]. Musculoskeletal/deep-tissue pain has been found to be present at multiple sites including the arms, chest and lower back in a questionnaire-based study of 27 adult patients with mean age of 31.77 years [22].…”

Section: Subjects With Scd Transgenic Mice Expressing Sickle Hemoglobinmentioning

confidence: 99%

Mechanisms of Pain in Sickle Cell Disease

Aich¹,

Beitz²,

Gupta³

2016

Sickle Cell Disease - Pain and Common Chronic Complications

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Pain is one of the most common features of sickle cell disease SCD lacking efective therapy. Pain in SCD is relatively more complicated than other conditions associated with pain requiring understanding of the pathobiology of pain speciic to SCD. The characterization of pain to deine the diverse modalities of nociception in SCD is currently under progress via human studies accompanied by transgenic mouse models of SCD. Sickle pathobiology characterized by oxidative stress, inlammation and vascular dysfunction contributes to both peripheral and central nociceptive sensitization via mast cell activation in the periphery, and reactive oxygen species and glial activation and endoplasmic reticulum stress in the spinal cord among other efectors. These efects are mediated via several cellular receptors, which can be targeted to produce positive therapeutic outcomes. In this chapter, we will discuss the present understanding of molecular mechanisms of SCD pain and outline the mechanism-based translational potential of novel actionable targets to treat SCD pain.Keywords: pain, sickle cell disease, neurogenic inlammation, substance P, mast cell . IntroductionPain is a hallmark feature of sickle cell disease SCD , which can start in infancy, leading to hospitalization, reduced survival and poor quality of life. Pain in SCD is unique because of unpredictable and recurrent episodes of acute pain due to vaso-occlusive crises VOC , in addition to chronic pain experienced by a majority of adult patients on a daily basis [1]. Treatment choices remain limited to opioids, which impose liabilities of their own including constipation, mast cell activation, fear of addiction and respiratory depression [2]. Moreover, signiicantly larger doses of opioids are required to treat pain in SCD as compared to other acute and chronic pain conditions [1]. Pain can be lifelong in SCD and may therefore inluence © 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.cognitive function and lead to depression and anxiety, which can in turn promote the perception of pain [1].Treatment of chronic pain remains unsatisfactory overall, perhaps due to the diverse pathobiology in diferent diseases. Therefore, it is critical to understand the mechanisms speciic to the genesis of sickle pain to develop targeted therapies. Vascular dysfunction, inlammation, ischemia/reperfusion injury and oxidative stress in the wake of VOC can each evoke activation of the nociceptive nerve ibers leading to acute pain. On the other hand, con...

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Section: Subjects With Scd Transgenic Mice Expressing Sickle Hemoglobinmentioning

confidence: 99%

Mechanisms of Pain in Sickle Cell Disease

Aich¹,

Beitz²,

Gupta³

2016

Sickle Cell Disease - Pain and Common Chronic Complications

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“…22 It also agrees with the study of Chinawa et al, 19 that reported lower limb and upper limb pain as the common cause of admitted cases of SCA in their study. In the same line 23 reported pain crises including painful bone crisis to occur in all participants in their study as it is the most prevalent cause of health care consultation.…”

Section: Discussionmentioning

confidence: 65%

“…26 The disease is thought to have a high tropism for patients with SCA. 23 However, Zanoni et al, 3 are of the opinion that in addition to the sensitivity of salmonella with SCA patients, the bad hygienic life conditions of the concerned population can explain an endemicity of salmonellosis in some regions especially in the developing countries, therefore buttressing the high prevalence of osteomyelitis among SCA patients in a developing country like Nigeria. The prevalence of septic arthritis in the current study is similar with previous reported prevalence of 6-15%.…”

Section: Discussionmentioning

confidence: 99%

Musculoskeletal complications in sickle cell anemia patients: a ten-year retrospective review of hospital-based records (1991-2000) in two Nigerian hospitals

Aliyu

Rufa’i

Saidu

et al. 2015

Int J Contemp Pediatr

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“…Ohara et al [78] verified the relation between musculoskeletal pain in persons with sickle-cell anaemia, and their quality of life, as well as their social and economic characteristics. These researchers used the NMQ and the SF-36 health questionnaire.…”

Section: Pathologies Health and Ageingmentioning

confidence: 98%

Applications of the Standardized Nordic Questionnaire: A Review

et al. 2017

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Sustainability seeks to provide economically viable products in an environmentally friendly way while respecting worker rights. Physical wellbeing forms part of these rights. Musculoskeletal disorders (MSD) diminish productivity, cause absence from work, impose costs on the public health system and can cast doubt on the sustainability of a company or a product. The objective of the present work is to review the literature on the application of the Nordic Musculoskeletal Questionnaire (NMQ) on a worldwide level. In this work, the use of the NMQ has been classified by categories of knowledge, countries and years. The search was made using "Web of Science-Core Collection". In total, 259 articles were chosen from scientific journals and conferences related, according to the title and or abstract, to the practical application of the questionnaire. In conclusion, the NMQ has been applied mainly in three sectors: "activities related to treating human health and social issues", "manufacturing industries", and "agriculture, livestock, fishing, and forestry". The NMQ is an indirect method commonly used individually or complemented with other methods for evaluating the MSD and possible associated psychosocial and labour risks. The use of NMQ can help in the evaluation of the sustainability of a company.

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Musculoskeletal pain, profile and quality of life of individuals with sickle cell disease

Abstract: Background: Sickle cell disease is a prevalent condition in Brazil. Its clinical presentation includes vascular occlusion that result in ischemia,

Cited by 19 publications

References 25 publications

Mechanisms of Pain in Sickle Cell Disease

Mechanisms of Pain in Sickle Cell Disease

Musculoskeletal complications in sickle cell anemia patients: a ten-year retrospective review of hospital-based records (1991-2000) in two Nigerian hospitals

Applications of the Standardized Nordic Questionnaire: A Review

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