Características demográficas e clínicas de uma coorte de pacientes com artrite reumatoide inicial

Abstract

Introduction: Very few studies carried out with Latin American populations on the demographic and clinical characteristics of patients diagnosed with early rheumatoid arthritis (RA) can be found in the literature. Objective: To characterize a population of patients with early RA, prospectively followed, concerning demographic and clinical aspects and compare them with other similar cohorts. Patients and methods: The data presented are part of an incident cohort prospective study, in which 65 patients with early RA were evaluated and followed regularly for 36 months at the Early Rheumatoid Arthritis Outpatient Clinic of the University Hospital of Brasília (HUB, from the Portuguese). The demographic and clinical data of the initial evaluation, including general characteristics, clinical history, and physical examination were recorded. Descriptive statistics of the variables was applied. Results: Women (86%) with a mean age of 45.6 years, Caucasian or Black (47.6%), belonging to intermediate-low social classes (53.85%), with 8.3 years of schooling, predominated. The presenting symptoms of the majority of patients were acute (76.9%), with polyarticular onset (69.2%), persistent synovitis of the hands (90.7%), and prolonged morning stiffness (157 minutes on average). Patients had a high average score of painful (18.6) and swollen (13.9) joints and high prevalence of rheumatoid nodules (15.3%), which suggests disease with aggressive presentation in its initial phases. Conclusion: The demographic and clinical characteristics of patients enrolled in this Brazilian cohort differed, on several aspects, from previously published North American, European, and Latin American cohorts.

Sensitivity and specificity of assessment instruments of quality of life in rheumatoid arthritis

“…26 The majority of the sample of this study was made up of women (9:1) and was similar to the findings of various studies that involved persons with RA in Latin American Countries. 4,27 However, it differed from the findings of American studies, which revealed a ratio of 3:1 1,9,28,29 and European, of 2:1. 17 The demographic characteristics may have influenced these results, as there is still a scarcity of Brazilian results.…”

“…10,30 Latin American countries present very complex demographic aspects with a highly miscegenated population, and elevated diversity of genetic expression. 1,27 Women also have less propensity to attain remission after treatment. 10 The mean age of our patients was similar to that found in other studies of populations with RA.…”

Rheumatoid artrhitis treatment in Brazil: data from a large real-life multicenter study

“…Biological DMARD use (36.1%) in our cohort was more frequent than in studies of early RA conducted in Brazil and Latin America [17,19,21]. Patients treated early in the course of disease are supposed to respond better and to require less of the more advanced resources, such as biological DMARDs, in the stepwise approach to RA management [23].…”

“…A high prevalence of rheumatoid factor was observed (78.7%), similar to that in other Latin American and Brazilian studies. This feature has been associated with more aggressive disease, worse prognosis and possibly extra-articular manifestations [19,21]. A high positivity rate for anti-CCP (76.8%) was also found.…”

Uma Abordagem Sobre a Inter-Relação De Citocinas Na Artrite Reumatóide.

“…2 Discente do Curso de graduação em Farmácia da FAEMA. 3 Especialista em Hematologia, Professora do Curso de Farmácia na Faculdade de Educação e Meio Ambiente -FAEMA, Ariquemes -RO;…”