Síndrome antifosfolípide primária e infecções por hepatites B e C

Abstract

Objective:The objective of the present study was to evaluate the prevalence of hepatitis B and C serology in patients with primary antiphospholipid syndrome (APS). Methods: This is a transversal study with 47 patients with primary APS (Sapporo's criteria). Demographic and clinical data, medications, and hepatitis B and C serologies, with PCR in positive cases, were evaluated. Results: The study population had a mean age of 38±11 years, 80.8% were females, and 68% Caucasian. The mean duration of the disease was 67 ± 61 months (ranging from 1 to 240 months). Arterial events were seen in 61.7% of the patients, venous events in 51%, and obstetric events in 38.3%. Five (10.6%) patients with primary APS had positive serologies for hepatitis B or C. Three of them were positive for anti-HBs, and only one was anti-HBc positive; the other two patients were positive for hepatitis C. Qualitative PCR did not detect hepatitis C viral RNA in neither of the positive patients. Conclusion: A small percentage of patients with primary APS had positive serology for hepatitis B and C, and all represented cases post-vaccine or serology scar. Females, n (%) 38 (80.8) Caucasian, n (%) 32 (68.0) Duration of the disease, (range), months 67 ± 61 (1-240) Arterial events, n (%) 29 (61.7) Venous events, n (%) 24 (51.0) Obstetric events, n (%) 18 (38.3) Positivity for aCL IgG, n (%) 28 (59.6) Positivity for aCL IgM, n (%) 25 (53.1) Positivity for LA, n (%) 38 (80.8) Data presented as mean ± standard deviation or percentage; aCL: anticardiolipin antibody; LA: lupus anticoagulant.