O uso de provas de atividade inflamatória em reumatologia

Neto, Nilton Salles Rosa; Carvalho, Jozélio Freire de

doi:10.1590/s0482-50042009000400008

Cited by 13 publications

(3 citation statements)

References 44 publications

(31 reference statements)

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“…Diante disso, o resultado encontrado neste estudo sobre o FR pode justificar o índice mais elevado de DAS28 PCR observado no grupo Anêmicas em relação ao grupo Não anêmicas. Conforme alguns autores já demonstraram, existe uma associação direta entre os níveis de PCR e FR [22,23].…”

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“…Este escore de atividade de doença é amplamente empregado na avaliação clínica, principalmente em função do custo reduzido do marcador VHS em relação à PCR quantitativa, porém, alguns pontos precisam ser considerados. A VHS sofre forte interferência de variáveis não relacionadas ao processo inflamatório e reflete a atividade inflamatória de algumas semanas, apresentando maior sensibilidade para alterações lentas [22].…”

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“…A PCR não sofre a mesma influência dos fatores citados sobre a VHS e reflete mudanças de curto prazo, sendo mais sensível para alterações rápidas na atividade de doença. Existe também uma boa correlação da PCR com a terapêutica e a progressão radiológica [22].…”

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Anemia e índices de atividade de doença em mulheres com artrite reumatoide

Scheffel¹,

Prado²,

Staub³

et al. 2018

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. ABSTRACT AIMS: To evaluate disease activity indexes in female patients with rheumatoid arthritis, Anemic and Non-anemic, correlating them with hemoglobin levels. METHODS: A cross-sectional study involved women with rheumatoid arthritis classified into two groups: 1) Anemic (hemoglobin < 12 g/dL) and 2) Non-anemic. Disease activity was measured by Disease Activity Index (DAS28), using different inflammatory markers: Erythrocyte Sedimentation Rate (ESR) and C-reative Protein (CRP). This score also uses the number of swollen and painful joints and an overall assessment of the disease on Visual Analogue Scale (VAS). An assessment of functional capacity by the Health Assessment Questionnaire (HAQ) was also performed. The statistic used Student's t-Test, Mann-Whitney, Wilcoxon, Fisher, likelihood ratio and Spearman correlation tests. It was considered significant p < 0,05. RESULTS: Twenty-four patients were included, eight patients in the Anemic group and 16 patients in the Non-anemic group. The groups were similar in terms of clinical, demographic and treatment characteristics, differing only in relation to rheumatoid factor, positive in all anemic participants and in 56,2% of non anemic participants. DAS28 ESR (median 6,05; interquartile range [IQR] 5,21-7,76), DAS28 CRP (median 4,32; IQR 3,98-5,92) and VAS (median 66,50 mm; IQR 54,(75)(76)(77)(78)(79)(80)50) were significantly higher in Anemic group. DAS28 ESR (-0,418) and VAS (-0,426) showed a significant negative correlation with hemoglobin level. DAS28 ESR and DAS28 CRP values were different in the same group, showing a discrepancy in the categorization of disease activity. In Anemic group, DAS28 ESR value (median 6,05; IQR 5,21-7,76) was higher in relation to DAS28 CRP (median 4,32; IQR 3,92). A less discrepant increase of DAS28 ESR (median 4,01; IQR 3,05-5,68) compared to DAS28 CRP (median 3,06; IQR 2,18-4,66) was observed in Non-anemic group. CONCLUSIONS: Anemia was associated with worse disease activity indexes in women with rheumatoid arthritis, being correlated with greater pain intensity and increase of DAS28 ESR score.

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Anemia e índices de atividade de doença em mulheres com artrite reumatoide

Scheffel¹,

Prado²,

Staub³

et al. 2018

Sci Med

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High neutrophil‐to‐lymphocyte ratio at intensive care unit admission is associated with nutrition risk in patients with COVID‐19

Martins

Gomes

Franco

et al. 2022

J Parenter Enteral Nutr

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Background Inflammation plays a crucial role in nutrition status and can be useful in early nutrition risk screening of patients during the coronavirus disease 2019 (COVID‐19) pandemic. Thus, this study aimed to assess the association between systemic inflammatory markers and nutrition risk tools in intensive care unit (ICU) patients with COVID‐19. Methods Patients with confirmed COVID‐19 and ICU admission were enrolled in a retrospective, observational, cross‐sectional study. The medians of C‐reactive protein (CRP; ≥13.8 mg/dl) and the neutrophil‐to‐lymphocyte ratio (NLR; ≥12.6) upon admission were used to dichotomize patients. Results Of the 73 patients, 63% were men; the average age was 56 years, and the median length of hospital stay was 10 (25th: 4; 75th: 17) days. When nutrition risk screening tools were used, 85% were at risk according to Nutritional Risk Screening (≥3 points), whereas 42% had high risk according to the Modified Nutrition Risk in the Critically Ill (mNUTRIC; ≥5 points), and 57% were moderately or severely malnourished according to the Subjective Global Assessment (B or C). Mortality was higher in the group with NLR ≥12.6 than in the group with NLR <12.6, with no difference between CRP groups. A significant association was found only between NLR and mNUTRIC, even when adjusted by sex, age, and body mass index (odds ratio, 1.36; 95% CI, 1.06–1.76; P = 0.016), but not between CRP and nutrition risk. Conclusion Although the inflammatory marker CRP is the most used in hospital clinical practice, we found that only NLR was associated with nutrition risk (NUTRIC score).

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Matrix Metalloproteases as Biomarkers of Disease

Fonseca

Alves

Azzalis

et al. 2017

Methods in Molecular Biology

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Matrix metalloprotease play a vital role in many cellular processes. Dysfunction in activity of these enzymes has been implicated in the pathogenesis of a number of diseases. Factors that affect the balanced interaction between MMPs and their inhibitors, such as genetic mutations of extracellular matrix components or dysregulation of MMP expression, can lead to various diseases. Due to their essential role in ECM remodeling, MMPs have become targets of interest as biomarkers for the diagnosis and prognosis of diseases associated with alterations of the ECM.

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O uso de provas de atividade inflamatória em reumatologia

Cited by 13 publications

References 44 publications

Anemia e índices de atividade de doença em mulheres com artrite reumatoide

Anemia e índices de atividade de doença em mulheres com artrite reumatoide

High neutrophil‐to‐lymphocyte ratio at intensive care unit admission is associated with nutrition risk in patients with COVID‐19

Matrix Metalloproteases as Biomarkers of Disease

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