Freqüência de síndrome metabólica em pacientes com nefrite lúpica

Cunha, Bernardo Matos da; Klumb, Evandro Mendes; Moura, Jaqueline Quintanilha; Santos, Amanda; Pinheiro, Geraldo da Rocha Castelar; Albuquerque, Elisa; Levy, Roger A.

doi:10.1590/s0482-50042008000500003

Cited by 3 publications

(3 citation statements)

References 33 publications

(53 reference statements)

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“…2,8 Hyperinsulinemia increases oxidative stress, which is considered an important pathophysiological mechanism for the development of atherosclerosis. Some studies have evidenced that DM is signifi cantly more common in patients with SLE than in the general population, because of the reduced insulin sensitivity, and that approximately 18%-38% of the patients have MS. 2,9,10 It is worth noting that more than half of the patients with SLE have three or more risk factors for cardiovascular disease, particularly obesity, SAH, and dyslipidemias, suggesting that they are really more susceptible to the MS. 2,11 A Brazilian assessment of the nutritional status of 170 patients with SLE has reported a 1.2% prevalence of grade I thinness and a 64.2% prevalence of excessive weight (35.9% of overweight; 21.8% of grade I obesity; 4.1% of grade II obesity; 2.4% of grade III obesity). Eutrophy, according to the Body Mass Index (BMI), has been observed in only 34.7% of the patients assessed, leading to the conclusion that excessive weight is a frequent fi nding during the follow-up of patients with SLE.…”

Section: Introductionmentioning

confidence: 99%

Dieta e aspectos nutricionais no lúpus eritematoso sistêmico

Klack

Bonfá²,

Borba³

2012

Rev. Bras. Reumatol.

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The authors reviewed the infl uence of nutritional factors on systemic lupus erythematosus (SLE) and discussed an alternative treatment option. The autoimmunity and infl ammatory process of SLE are related to the presence of dyslipidemia, obesity, systemic arterial hypertension, and metabolic syndrome, which should be properly considered to decrease cardiovascular risk. A diet with moderate protein and energy content, but rich in vitamins, minerals (especially antioxidants), and mono/ polyunsaturated fatty acids can promote a benefi cial protective effect against tissue damage and suppression of infl ammatory activity, in addition to helping the treatment of those comorbidities. Diet therapy is a promising approach and some recommendations may offer a better quality of life to patients with SLE.

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Section: Introductionmentioning

confidence: 99%

Dieta e aspectos nutricionais no lúpus eritematoso sistêmico

Klack

Bonfá²,

Borba³

2012

Rev. Bras. Reumatol.

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“…Possibly, a longitudinal evaluation of the patients included in this analysis could be different. There is a strong association between metabolic syndrome and lupus nephritis [1]. However, it has not been clear how the link between the severity of nephritis, the intensity of immunosuppression, and the presence of metabolic syndrome exists.…”

Section: Discussionmentioning

confidence: 99%

“…Systemic lupus erythematosus (SLE) is an autoimmune disease, with a multifactorial etiology and clinical manifestations related to the most diverse organs. Among these, nephritis, which is capable of progressing to chronic kidney disease, is associated with a higher risk of progression to cardiovascular diseases, as a consequence of damage to renal function [1].…”

Section: Introductionmentioning

confidence: 99%

Evaluation Of Risk Factors In Cardiovascular Patients With Diagnosis Of Systemic Lupus Erythematosus (SLE)

Lobato¹,

Santos²,

Marinho³

et al. 2018

int arch med

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Title: Evaluation of risk factors in cardiovascular patients with diagnosis of Systemic Lupus Erythematosus (SLE). Background: prevalence of cardiovascular risk factors in lupic patients.This study aimed to evaluate the presence of cardiovascular risk factors in patients diagnosed with SLE in a Rheumatology Ambulatory, comparing groups with and without SLE nephritis. Methods: a quantitative, observational and cross-sectional study was carried out during the period from November 2016 to June 2017. 86 patients were interviewed using specific protocol. Conclusions: among the cardiovascular risk factors evaluated, systemic hypertension was more frequent in SLE patients (33.7%), followed by smoking (17.4%) and diabetes mellitus (5.8%). There was, however, no difference between the frequency of these comorbidities in the groups with and without lupus nephritis.

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Rubéola e autoimunidade

Altman¹,

Shoenfeld²

2012

Rev. Bras. Reumatol.

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olecular mimicry has been proposed as a pathogenic mechanism for autoimmune disease. The hypothesis is based on the epidemiological, clinical, and experimental studies and in evidence fi nding an association between infectious agents and autoimmune disease, observing cross-reactivity of immune agents with host antigens and microbial determinants. 1 Recent studies have revealed that carbohydrate mimicry of bacterial lipo-oligosaccharide by the human ganglioside is an important cause of Guillain-Barré syndrome, for example. This new concept that carbohydrate mimicry can cause an autoimmune disease provides a clue of the pathogenesis of immune-mediated diseases. 1 Molecular mimicry is based on a structural similarity between a pathogen or metabolite and self-structure. The similarity could be expressed as shared amino acid sequences or as a similar conformational structure between a pathogen and self-antigen. 2 The strongest association of viruses and type 1 diabetes (T1D) involves enterovirus species, of which some strains have the ability to induce or accelerate autoimmune disease in animal models. Several hypotheses regarding the mechanism to explain how viruses affect islet autoimmunity and beta-cell destruction were proposed. 3 Viral infection may serve as an accelerating factor that, superimposed onto advanced insulinitis, leads to rapid culmination into hyperglycemia. Rubella virus is a possible environmental agent which may be involved in the triggering of autoimmunity to pancreatic islet cells, leading to T1D. Autoantibody responses were found in 239 10-year-old girls who received live attenuated rubella vaccine, of whom 61 (26%) had no pre-existing rubella immunity. 4 Infection can promote the expression of human endogenous retroviruses by molecular mimicry or by functional mimicry. 5 There are additional mechanisms which may control the expression of human endogenous retroviruses, such as the epigenetic status of the genome. 6 T1D develops during months to years, in which islet autoimmunity destroys the insulin-producing beta cells of the pancreas. This period is marked by the presence of antibodies Rubella and autoimmunity

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Freqüência de síndrome metabólica em pacientes com nefrite lúpica

Cited by 3 publications

References 33 publications

Dieta e aspectos nutricionais no lúpus eritematoso sistêmico

Dieta e aspectos nutricionais no lúpus eritematoso sistêmico

Evaluation Of Risk Factors In Cardiovascular Patients With Diagnosis Of Systemic Lupus Erythematosus (SLE)

Rubéola e autoimunidade

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