Vasculite na hanseníase mimetizando doenças reumáticas

Ribeiro, Sandra Lúcia Euzébio; Guedes, Erilane Leite; Pereira, Helena Lúcia Alves; Souza, Lucilene Sales de

doi:10.1590/s0482-50042007000200013

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…2 The literature describes leprosy patients who were initially diagnosed with and treated for systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), dermatopolymyositis, and systemic vasculitis. [3][4][5][6][7][8] Those systemic manifestations are seen mainly in multibacillary leprosy, especially during reactional states, and are secondary to the direct infiltration and proliferation of the bacillus in the affected organ. [2][3][4][5][6][7][8][9] Systemic manifestations include malar erythema, subcutaneous nodules, ulcerations, purpuras, ischemic necrosis, Raynaud's phenomenon, polyneuropathy, multiple mononeuritis, muscle weakness, generalized lymphadenopathy, hepatosplenomegaly, and glomerulonephritis.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8] Those systemic manifestations are seen mainly in multibacillary leprosy, especially during reactional states, and are secondary to the direct infiltration and proliferation of the bacillus in the affected organ. [2][3][4][5][6][7][8][9] Systemic manifestations include malar erythema, subcutaneous nodules, ulcerations, purpuras, ischemic necrosis, Raynaud's phenomenon, polyneuropathy, multiple mononeuritis, muscle weakness, generalized lymphadenopathy, hepatosplenomegaly, and glomerulonephritis. 2,[8][9][10] The presence of rheumatoid factor, anti-cyclic citrullinated antibodies, ANF, anticardiolipin antibodies, antineutrophil cytoplasmic antibodies, and others are among the serologic changes observed.…”

Section: Discussionmentioning

confidence: 99%

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Manifestações sistêmicas e ulcerações cutâneas da hanseníase: diagnóstico diferencial com outras doenças reumáticas

Ribeiro¹,

Guedes²,

Pereira³

et al. 2009

Rev. Bras. Reumatol.

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Leprosy is a systemic disease with predominant involvement of skin and nerves; articular manifestations are common and, in some cases, represent the initial complaint. We describe the case of a female patient with borderline leprosy, which manifested, initially, with symmetric polyarthritis, cutaneous ulcerative lesions on the lower limbs, and systemic manifestations mimicking rheumatic disease. The authors emphasize the importance of the differential diagnosis of the systemic, joint and, cutaneous involvement of leprosy with rheumatic diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Manifestações sistêmicas e ulcerações cutâneas da hanseníase: diagnóstico diferencial com outras doenças reumáticas

Ribeiro¹,

Guedes²,

Pereira³

et al. 2009

Rev. Bras. Reumatol.

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“…Additionally, circa of 30-40% of patients develops sudden and acute in ammatory episodes as so-called reactions. Type 1 or RR present clinically with neuritis or erythema or edema of the skin lesions; type 2 or ENL, involves the appearance of subcutaneous nodules and symptoms such as fever, arthritis, neuritis, among others [2]. MicroRNAs are well-known small noncoding RNA molecules that control gene expression by interacting with mRNAs in practically all biological processes.…”

Section: Introductionmentioning

confidence: 99%

The miR-125a-3p is Associated With Leprosy Phenotypes and Correlated With Bacillary Index

Santana

Lago

Vieira

et al. 2021

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Background. Mycobacterium leprae infects skin and peripheral nerves causing a broad of clinical forms. Data have shown that the miR-125a-3p can influence immune mechanisms such as autophagy as well as to target genes leading to abnormal proliferation, metastasis, and invasion of cells. Methods. Here we used quantitative real time PCR (qPCR) to evaluate the miR-125a-3p expression pattern as a marker for leprosy phenotypes in biopsies obtained from patients with and without reactions. Data were analysed according to clinical forms and bacillary index (BI). Results. Our results show a significant increase in the miR-125a-3p expression in paucibacillary (PB) vs multibacillary (MB) (p = 0.007) and vs RR (reversal reactions) (p = 0.005), respectively; and also a higher expression in patients with erythema nodosum leprosum (ENL) vs MB without reactions (p = 0.002). In addition, there was a positive correlation between the miR-125a-3p expression and BI in patients with reactions (r=0,81; p=0,002). Conclusions. All together we underpin a role for miR-125-3p in leprosy pathogenesis, raising the hypothesis that this miR might have a distinct role in PB and ENL forms, influencing mechanisms such as apoptosis and autophagy according to the local context. A functional study should help to validate the miR-125a-3p as a potential therapeutic target for leprosy treatment.

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“…Joint involvement can manifest as symmetrical polyarthritis of small and large joints, simulating rheumatoid arthritis. 4,7,8 Besides the wide variability in the prevalence of the different autoantibodies in patients with leprosy reported in the literature, there are few studies correlating the presence of autoantibodies and joint manifestations of this disease. 4,9,11,12 Bras J Rheumatol 2009;49(5):547-61…”

Section: Introductionmentioning

confidence: 99%

Autoanticorpos em pacientes com hanseníase, com e sem comprometimento articular, no Estado do Amazonas

Ribeiro¹,

Pereira²,

Silva³

et al. 2009

Rev. Bras. Reumatol.

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Objective: Determine the frequency of rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibodies (anti-CCP), antinuclear antibodies (ANA), antineutrophil cytoplasmic antibodies (ANCA), anticardiolipin antibodies (aCL), and anti-β 2 glycoprotein I antibodies (anti-β 2 GPI) in leprosy patients, with and without joint involvement, and to evaluate the possible association among those antibodies and articular manifestations, clinical type, reactional episodes, polychemotherapic treatment (PCT), and discharge from PCT. Patients and methods: One hundred and fifty-eight leprosy patients were divided in two groups of 73 patients (Group I) and 82 patients (Group II). Group III was composed of 129 healthy individuals. Methods: Semi-quantitative latex agglutination test for IgM-RF, indirect immunofluorescence for ANA and ANCA, and ELISA for anti-CCP, aCL, and anti-β 2 GPI. Results: Fifty-six (35.4%) of 158 leprosy patients had lepromatous leprosy (LL). The frequency of anti-CCP, RF, and ANA antibodies in Groups I and II was similar to that of Group III. Antineutrophil cytoplasmic antibodies were not detected in any patient. Anticardiolipin antibodies were more frequent in leprosy patients (Groups I and II) than in control group (15.8% vs. 3.1%; P < 0.001), and differences between Groups I and II (P = 0.67) were not observed. Anti-β 2 GPI antibodies were also more common in leprosy patients than in control group (46.2% vs. 9.4%; P < 0.001), without differences between Groups I and II. A predominance of IgM isotype over IgG isotype was observed both for aCL (88% vs. 16%; P = 0.001) and anti-β 2 GPI (97.3% vs. 12.3%; P < 0.001). Patients did not present manifestations suggestive of vascular thrombosis. Conclusion: The frequency of aCL and anti-β 2 GPI antibodies was significantly increased in leprosy patients than in healthy individuals. However, positivity to other autoantibodies was similar to that observed in the control group. An association between autoantibodies and joint involvement, reactional episodes, polychemotherapic treatment, discharge, and clinical type of leprosy was not observed, except for aCL antibodies, which were more frequent in lepromatous leprosy.

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Vasculite na hanseníase mimetizando doenças reumáticas

Cited by 8 publications

References 8 publications

Manifestações sistêmicas e ulcerações cutâneas da hanseníase: diagnóstico diferencial com outras doenças reumáticas

Manifestações sistêmicas e ulcerações cutâneas da hanseníase: diagnóstico diferencial com outras doenças reumáticas

The miR-125a-3p is Associated With Leprosy Phenotypes and Correlated With Bacillary Index

Autoanticorpos em pacientes com hanseníase, com e sem comprometimento articular, no Estado do Amazonas

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