Artrite reumatóide e doenças cardiovasculares

Abstract

artigo dE rEvisão rEviEw articlE RESUMO A maior prevalência das doenças cardiovasculares, particularmente da doença coronária, está bem estabelecida na artrite reumatóide (AR). Este trabalho, envolvendo uma revisão extensa da literatura, analisa as evidências epidemiológicas apontando as doenças cardiovasculares como a maior causa de mortalidade prematura na AR, os fatores de risco para doença coronária, a relação entre aterosclerose e AR, os mecanismos fisiopatológicos desta associação, incluindo o papel direto e indireto do processo inflamatório sistêmico e as características da doença coronária na AR. Finalmente, é destacada a importância dos cuidados preventivos para este paciente reumatóide com alto risco de eventos cardiovasculares. AbStRActThe increased prevalence of cardiovascular disease (CVD) in rheumatoid arthrtis (RA) patients is by now largely recognized. The purpose of this extensive literature review is to analyze the epidemiological evidences of CVD, particularly coronary heart disease (CHD), as the leading cause of early death in RA, the presence of coronary risk factors, the relationship between RA and atherosclerosis, the shared physiopathology mechanisms, including the systemic inflammatory process and the peculiarities of CHD in the rheumatoid population. Lastly, given the burden of cardiovascular disease in this population, it is emphasized the importance of preventive care in these high risk patients.

Potenciais interações medicamentosas em pacientes com artrite reumatoide

“…As the prevalence of comorbidities and risk factors, such as dyslipidemias, diabetes mellitus, hypertension, obesity, and osteoporosis, increases with age, 7 the prescription of concurrent medications is frequent in RA patients. In addition, the use of medications for symptomatic treatments and/or self-medication can further increase the number of drugs used by RA patients.…”

Artrite reumatoide e síndrome metabólica

“…There is evidence of an infl ammatory basis for atherosclerosis, which has led many researchers to study the relationship between systemic infl ammatory conditions, such as RA, and the risk for coronary heart disease. [7][8][9] Metabolic syndrome (MetS), a set of cardiovascular risk factors (such as central obesity, dyslipidemia, hypertension, and hyperglycemia), has been assessed aiming at predicting the risk for cardiovascular disease (CVD). 3 There is evidence showing the association between RA, its infl ammatory activity, and MetS, 2,3 but the results on the prevalence of this syndrome in RA are confl icting.…”

Effects of inhaled cigarette smoke on the myo-articular system of female rats with collagen-induced arthritis

“…If this condition is not controlled and is combined with a sedentary lifestyle, a compromised musculoskeletal system can cause a series of complications that culminate in a decrease in functionality and quality of life that is associated with increased rates of morbidity and mortality relative to the healthy population. 5 …”