Manifestações reumáticas associadas ao vírus linfotrópico humano de células T do tipo I (HTLV-I)

Cruz, Bóris Afonso; Catalan-Soares, Bernadette; Proietti, Fernando Augusto

doi:10.1590/s0482-50042005000200005

Cited by 6 publications

(3 citation statements)

References 53 publications

(64 reference statements)

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“…In an earlier study, a prevalence of 1.35% had been found in the same group, suggesting an apparent decrease in the infection in blood donors over the last decade in Salvador [Galvão‐Castro et al, 1997]. HTLV‐1 is associated with adult T‐cell leukemia (ATL) [Poiez et al, 1980] and HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) [Gessain et al, 1985; Osame et al, 1985] and has also been implicated in several disorders, such as uveitis [Mochizuki et al, 1996], Sjögren's syndrome [Nakamura et al, 2000], polymyositis [Cruz et al, 2005], and infective dermatitis [La Grenade et al, 1998].…”

Section: Introductionmentioning

confidence: 99%

Oral health profile in patients infected with HTLV‐1: Clinical findings, proviral load, and molecular analysis from HTLV‐1 in saliva

Lins

Carvalho

Rego

et al. 2012

Journal of Medical Virology

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Human T‐lymphotropic virus type 1 (HTLV‐1) is associated with adult T‐cell leukemia (ATL) and HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and has also been implicated in several disorders, including periodontal disease. The proviral load is an important biological marker for understanding HTLV‐1 pathogenesis and elucidating whether or not the virus is related to the clinical manifestation of the disease. This study describes the oral health profile of HTLV‐1 carriers and HAM/TSP patients in order to investigate the association between the proviral load in saliva and the severity of the periodontal disease and to examine virus intra‐host variations from peripheral blood mononuclear cells and saliva cells. It is a cross‐sectional analytical study of 90 individuals carried out from November 2006 to May 2008. Of the patients, 60 were HTLV‐1 positive and 30 were negative. Individuals from the HTLV‐1 positive and negative groups had similar mean age and social‐economic status. Data were analyzed using two available statistical software packages, STATA 8.0 and SPSS 11.0 to conduct frequency analysis. Differences of P < 0.05 were considered statistically significant. HTLV‐1 patients had poorer oral health status when compared to seronegative individuals. A weak positive correlation between blood and saliva proviral loads was observed. The mean values of proviral load in blood and saliva in patients with HAM/TSP was greater than those in HTLV‐1 carriers. The HTLV‐1 molecular analysis from PBMC and saliva specimens suggests that HTLV‐1 in saliva is due to lymphocyte infiltration from peripheral blood. A direct relationship between the proviral load in saliva and oral manifestations was observed. J. Med. Virol. 84:1428–1436, 2012. © 2012 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Oral health profile in patients infected with HTLV‐1: Clinical findings, proviral load, and molecular analysis from HTLV‐1 in saliva

Lins

Carvalho

Rego

et al. 2012

Journal of Medical Virology

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“…[4][5][6][7][8] The HTLV-1 causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T-cell leukemia (ATL) and rheumatologic diseases, [9][10][11][12] along with several other disorders.…”

Section: Introductionmentioning

confidence: 99%

Anti-Tax antibody levels in asymptomatic carriers, oligosymptomatic carriers, patients with rheumatologic disease or with HAM/TSP do not correlate with HTLV-1 proviral load

Souza

Fonseca

Martins

et al. 2011

Journal of Clinical Virology

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“…1,2,9,11 Brazil has approximately 2.5 million HTLV 1/2-seropositive individuals, and that pathology is endemic in the city of Salvador, Bahia state (1.8% of prevalence). 12,13 Some studies have suggested that HTLV is the trigger and perpetrator of some articular inflammatory diseases, because it induces an exuberant lymphocytic proliferative response in the immune system. Thus, it has been implicated in autoimmunity induction.…”

Section: Figurementioning

confidence: 99%

Piomiosite tropical em paciente com lúpus eritematoso sistêmico e infecção por HTLV 1/2

Souza¹,

Carvalho²,

Morais³

et al. 2011

Rev. Bras. Reumatol.

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Tropical pyomyositis (TP) is an unusual infectious disease of skeletal muscles, caused by bacteria, and often associated with immunodeficiency conditions. The involvement of deep pelvic muscles, such as the iliac muscle, is even rarer. The association of systemic lupus erythematosus (SLE) and PT is seldom reported in the literature. Because SLE involves a state of immunosuppression resulting from both the disease itself and its medicamentous treatment, SLE patients are at higher risk for developing infections, such as PT. Infection by HTLV 1/2 is increasingly identified and associated with autoimmune diseases, such as SLE. This is a case report of PT in the pelvic muscles of a female patient with SLE, chronic kidney failure, on hemodialysis, and HTLV1/2 infection, admitted to the Hospital Heliópolis, in the city of São Paulo, Brazil.

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Manifestações reumáticas associadas ao vírus linfotrópico humano de células T do tipo I (HTLV-I)

Cited by 6 publications

References 53 publications

Oral health profile in patients infected with HTLV‐1: Clinical findings, proviral load, and molecular analysis from HTLV‐1 in saliva

Oral health profile in patients infected with HTLV‐1: Clinical findings, proviral load, and molecular analysis from HTLV‐1 in saliva

Anti-Tax antibody levels in asymptomatic carriers, oligosymptomatic carriers, patients with rheumatologic disease or with HAM/TSP do not correlate with HTLV-1 proviral load

Piomiosite tropical em paciente com lúpus eritematoso sistêmico e infecção por HTLV 1/2

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