American tegumentary leishmaniasis: an uncommon clinical and histopathological presentation

Adriano, Adrilena Lopes; Leal, Paula Azevedo Borges; Breckenfeld, Marcelle Parente; Costa, Igor dos Santos; Almeida, C. A.; Sousa, Antônio Renê Diógenes de

doi:10.1590/s0365-05962013000200015

Cited by 4 publications

(4 citation statements)

References 6 publications

(7 reference statements)

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“…Since there was no successful treatment with second-line drugs available, meglumine antimoniate was used again, but intravenously. Although there is no difference between the intramuscular and intravenous routes, as regards the efficacy and safety of the drug 3 , the lesion finally receded after treatment with meglumine antimoniate administered intravenously.…”

Section: Discussionmentioning

confidence: 97%

“…ADRIANO et al . 3 reported a case of an unusual presentation of American tegumentary leishmaniasis involving a solitary lesion on the ear lobe, without ulceration. CALPOVINA et al .…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous leishmaniasis can produce a large variety of atypical and rare forms. There has been an increase in the number of papers reporting unusual clinical presentations, both for the Old and the New World 3 , 4 , 5 , 6 , 7 , 8 , 9 .…”

Section: Introductionmentioning

confidence: 99%

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American Cutaneous Leishmaniasis With Unusual Clinical Presentation and Response to Treatment

Fernandes

Pedroso

Venazzi

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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The clinical manifestations and prognosis of cutaneous leishmaniasis (CL) can be influenced by the immune response of the patient and the species of the parasite. A case of atypical clinical presentation of CL, with development of non-characteristic lesions, poor response to therapy, and a long time to resolution is reported. Confirmatory laboratory tests included parasite detection, indirect immunofluorescence, Montenegro skin test, polymerase chain reaction, and parasite identification by multilocus enzyme electrophoresis. The parasite was identified as Leishmaniabraziliensis. The lesion was unresponsive to three complete courses of N-methylglucamine antimoniate intramuscular, and to treatment with pentamidine. The patient did not tolerate amphotericin B. The lesion finally receded after treatment with intravenous N-methylglucamine antimoniate. It is essential to ensure the accuracy of diagnosis and the appropriate treatment, which can include the use a second choice drug or a different route of administration.

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Section: Discussionmentioning

confidence: 97%

“…ADRIANO et al . 3 reported a case of an unusual presentation of American tegumentary leishmaniasis involving a solitary lesion on the ear lobe, without ulceration. CALPOVINA et al .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

American Cutaneous Leishmaniasis With Unusual Clinical Presentation and Response to Treatment

Fernandes

Pedroso

Venazzi

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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“…Cutaneous Leishmaniasis can produce a large variety of atypical and rare forms. There has been an increase in the number of papers reporting unusual clinical presentations, both for the Old and the New World [8][9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of cutaneous Leishmaniasis in pregnancy: A case report

Chakiri¹,

Gallouj²,

Mernissi³

et al. 2017

Our Dermatol Online

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Genetic variant strains of Leishmania (Viannia) braziliensis exhibit distinct biological behaviors

et al. 2018

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A variety of clinical forms of American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis, as well as differing immune responses of patients, have been reported for an ACL focus in the state of Minas Gerais, Brazil. In addition, two genetic profiles of L. braziliensis have been described, of which one variant profile (hsp70-variant) has been associated with atypical lesions. We investigated the biological behavior of genetic variant strains of L. braziliensis isolated from patients with different clinical manifestations of ACL. Experimental infections were performed with golden hamsters for five L. braziliensis strains in standardized doses of 1 × 10 parasites per inocula. The characteristics of skin lesions, histopathological features, and parasite burden were independently analyzed at 30 and 60 days post-infection. The data revealed distinct patterns in the onset time of visible skin lesions as well as in lesion size and parasite burden among the strains. The extent and density of the inflammatory infiltrate differed among strains, although cellular composition of granulomas appeared similar. Multivariate analysis indicated the occurrence of two clusters: one comprising native strains (cluster 1) and one comprising the reference strain (cluster 2). Within cluster 1, the genetic variants of L. braziliensis did not group with the non-variant strain suggesting that the distinct patterns of biological behavior of these strains could be associated with the known genetic diversity previously described for them.

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American tegumentary leishmaniasis: an uncommon clinical and histopathological presentation

Cited by 4 publications

References 6 publications

American Cutaneous Leishmaniasis With Unusual Clinical Presentation and Response to Treatment

American Cutaneous Leishmaniasis With Unusual Clinical Presentation and Response to Treatment

Unusual presentation of cutaneous Leishmaniasis in pregnancy: A case report

Genetic variant strains of Leishmania (Viannia) braziliensis exhibit distinct biological behaviors

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