Multiple metastatic basal cell carcinoma with concurrent metastatic pleomorphic sarcoma in chronic lymphedema area: case report

Abstract

Chronic lymphedema presents as interstitial fluid retention due to a failure in the lymphatic system drainage. The affected region becomes more vulnerable immunologically and predisposed to the onset of neoplasms. Basal Cell Carcinoma is the most common sort of neoplasm, nevertheless it rarely metastisizes. Sarcomas are malignant mesenchymal neoplasms, locally aggressive, which can spread. Here is reported an infrequent case of multiple basal cell carcinoma, synchronous to a poorly differentiated pleomorphic sarcoma, both spreading to lymph nodes and arising from tissue compromised by chronic lymphedema.

A case of multiple basal cell carcinomas in an immunocompromised skin district: The aetiopathogenetic role of congenital lymphqedema

“…5,7 Furthermore, chronic lymphoedema has been shown to cause proangiogenic factors increase, in particular vascular endothelial growth factor (VEGF), which promotes skin carcinogenesis by altering cell growth and proliferation. 4,5 In literature, cases of basal cell carcinomas in immunocompromised districts caused by secondary lymphoedema have already been described 5,8,9 ; however, this would be the first reported case of three basal cell carcinomas arising from an ICD after a primary lymphoedema simultaneously.…”