HLA among Brazilian patients with spontaneous chronic urticaria and positive autologous serum skin test

Calamita, Zamir; Pelá, Andrea Bronhara; Gamberini, Márcia; Baleotti, Wilson; Filho, Odilon Marques de Almeida; Ruiz, Marcelo O.; Arevalo, Dione G.; Júnior, Antônio Fabron

doi:10.1590/s0365-05962012000400010

Cited by 6 publications

(7 citation statements)

References 28 publications

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“…79 Rates of ASST positivity were higher in patients with CSU compared with those in healthy control subjects, 26,[80][81][82] atopic patients, 80,83 and patients with inducible urticaria 80 in some studies but not others. 84,85 A positive ASST result is significantly associated with CSU and female sex. 83 A negative ASST result has a high predictive value for the absence of circulating functional AAbs.…”

Section: Type II Autoimmunitymentioning

confidence: 96%

Autoimmune chronic spontaneous urticaria: What we know and what we do not know

Kolkhir

Church

Weller

et al. 2017

Journal of Allergy and Clinical Immunology

253

170

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Chronic spontaneous urticaria (CSU) is a mast cell-driven skin disease characterized by the recurrence of transient wheals, angioedema, or both for more than 6 weeks. Autoimmunity is thought to be one of the most frequent causes of CSU. Type I and II autoimmunity (ie, IgE to autoallergens and IgG autoantibodies to IgE or its receptor, respectively) have been implicated in the etiology and pathogenesis of CSU. We analyzed the relevant literature and assessed the existing evidence in support of a role for type I and II autoimmunity in CSU with the help of Hill's criteria of causality. For each of these criteria (ie, strength of association, consistency, specificity, temporality, biological gradient, plausibility, coherence, experiment, and analogy), we categorized the strength of evidence as "insufficient," "low," "moderate," or "high" and then assigned levels of causality for type I and II autoimmunity in patients with CSU from level 1 (causal relationship) to level 5 (causality not likely). Based on the evidence in support of Hill's criteria, type I autoimmunity in patients with CSU has level 3 causality (causal relationship suggested), and type II autoimmunity has level 2 causality (causal relationship likely). There are still many aspects of the pathologic mechanisms of CSU that need to be resolved, but it is becoming clear that there are at least 2 distinct pathways, type I and type II autoimmunity, that contribute to the pathogenesis of this complex disease.

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Section: Type II Autoimmunitymentioning

confidence: 96%

Autoimmune chronic spontaneous urticaria: What we know and what we do not know

Kolkhir

Church

Weller

et al. 2017

Journal of Allergy and Clinical Immunology

253

170

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“…There are some studies investigating the association between chronic spontaneous urticaria and HLA antigens. In these studies, it has been shown that some alleles are susceptible to disease and some alleles may be protective [9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

The association between chronic spontaneous urticaria and HLA class I and class II antigen

et al. 2020

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Background/aim: Chronic spontaneous urticaria (CSU) is a chronic disease with an unknown etiology. In human leukocyte antigen (HLA) system, the association of class I and class II antigens with autoimmune diseases has been identified and HLA antigens that have a tendency to or can prevent chronic urticaria have been studied. The aim of this study is to investigate the association between chronic spontaneous urticaria and HLA class I and class II antigens. Materials and methods: A total of 80 subjects, 40 patients with CSU and 40 healthy individuals were enrolled in the study. DNA sample isolation from blood was primarily done by the real-time polymerase chain reaction (RT-PCR) technique for the first time. Using HLA SSP Typing Kit (ROSE Cat. No: 800118) PCR technique, HLA-A, B, C, DRB and DQB alleles from DNA samples were analyzed. Results: The mean age was 36.80 ± 9.48 years and the duration of the disease was 4.26 ± 5.18 years. Among the HLA class I and class II antigens, HLA-A was detected significantly more often in the control group (P = 0.039). HLA-DRB1 was more often detected in the CSU group but no statistical difference (P > 0.05). Conclusion: It can be considered that HLA-DRB1 may have a tendency to CSU, while HLA-A might prevent the disease.

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“…Urticaria is a highly prevalent condition with various clinical manifestations [ 130 – 132 ]. When the symptoms are present for less than six weeks it is considered acute urticaria (AU), otherwise it is termed chronic urticaria (CU) [ 131 , 133 ]. Although accurate data on the prevalence of urticaria is unavailable, it ranges from 0.03 to 11.3 % [ 130 , 134 ].…”

Section: Introductionmentioning

confidence: 99%

Particularities of allergy in the Tropics

Caraballo

Zakzuk

Lee

et al. 2016

World Allergy Organization Journal

115

140

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Allergic diseases are distributed worldwide and their risk factors and triggers vary according to geographical and socioeconomic conditions. Allergies are frequent in the Tropics but aspects of their prevalence, natural history, risk factors, sensitizers and triggers are not well defined and some are expected to be different from those in temperate zone countries. The aim of this review is to investigate if allergic diseases in the Tropics have particularities that deserve special attention for research and clinical practice. Such information will help to form a better understanding of the pathogenesis, diagnosis and management of allergic diseases in the Tropics. As expected, we found particularities in the Tropics that merit further study because they strongly affect the natural history of common allergic diseases; most of them related to climate conditions that favor permanent exposure to mite allergens, helminth infections and stinging insects. In addition, we detected several unmet needs in important areas which should be investigated and solved by collaborative efforts led by the emergent research groups on allergy from tropical countries.Electronic supplementary materialThe online version of this article (doi:10.1186/s40413-016-0110-7) contains supplementary material, which is available to authorized users.

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HLA among Brazilian patients with spontaneous chronic urticaria and positive autologous serum skin test

Cited by 6 publications

References 28 publications

Autoimmune chronic spontaneous urticaria: What we know and what we do not know

Autoimmune chronic spontaneous urticaria: What we know and what we do not know

The association between chronic spontaneous urticaria and HLA class I and class II antigen

Particularities of allergy in the Tropics

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