Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review

Abstract

<jats:p>BACKGROUND: Non-melanoma skin cancer, a common designation for both basal cell carcinomas and squamous cell carcinomas, is the most frequent malignant skin neoplasm. OBJECTIVE: Epidemiologic characterization of the population with Non-melanoma skin cancer. METHODS: Retrospective analysis of all patients diagnosed with Non-melanoma skin cancer based on histopathologic analysis of all incisional or excisional skin biopsies performed between 2004 and 2008 in a Department of Dermatology. RESULTS: A total of 3075 Non-melanoma skin cancers were identified, representing 88% of all malignant skin neoplasms (n=3493) diagnosed in the same period. Of those, 68,3% were basal cell carcinomas. Most Non-melanoma skin cancer patients were female and over 60 years old. Of all Non-melanoma skin cancer, 81,7% (n=1443) were located in sun-exposed skin, and represented 95,1% of malignant skin neoplasms in sun-exposed skin. Non-melanoma skin cancer was the most frequent malignant skin neoplasm in most topographic locations, except for abdomen and pelvis - over 95% of all malignant skin neoplasms in the face, neck and scalp were Non-melanoma skin cancer. Basal cell carcinomas were clearly predominant in all locations, except in upper and lower limbs, lower lip and genitals, where squamous cell carcinomas represented respectively 77,7%, 77,4%, 94,7% and 95,3% of the Non-melanoma skin cancers. CONCLUSION: Being the most common skin cancer, Non-melanoma skin cancer should be under constant surveillance, in order to monitor its epidemiologic dynamics, the efficiency of preventive measures and the adaptation of the healthcare resources.</jats:p>

Co-Expression of Putative Cancer Stem Cell Markers, CD133 and Nestin, in Skin Tumors

“…Malignant skin cancers are an extremely heterogeneous group of diseases that are very common among various populations (Andrade et al, 2012). There are three main types of skin cancer including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma (Andrade et al, 2012).…”

“…There are three main types of skin cancer including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma (Andrade et al, 2012). BCC and SCC are derived from keratinocytes, while melanomas originate from melanocytes (La Porta and Zapperi, 2013).…”

Body Site Distribution and Relative Tumor Density of Different Human Cutaneous Malignancies with Emphasis on Sunlight Exposure: A Single Institution Experience

“…Although it is generally accepted that both BCCs and SCCs develop most frequently in the head and neck region, the percentages of tumors in this body part significantly differ among analyses conducted from various countries. Most of the published documents comprising Italian [3], Slovakian [8], Brasilian [9][10][11], Portuguese [12], and Romanian [7], or Iranian [13] studies have found, the head and neck represented 73.6-96.8% of all BCCs [3,7,8,[10][11][12][13] and 70.2-77.6% of all SCCs [3,[7][8][9]12] analyzed. In this study, this body part comprised 69% of BCCs and 81.5% of SCCs diagnosed, corroborating above-mentioned papers.…”

“…These UVR-related differences result in distinct anatomic distribution of the skin cancer types. In general, while MMs arise most commonly on the trunk and limbs [2][3][4][5][6][7], the vast majority of research papers have clearly demonstrated [3,[7][8][9][10][11][12][13] that NMSC occurs predominantly on the head and neck region. In spite of that, however, some studies [4,5,[14][15][16] have found discrepant percentages of BCCs and SCCs at individual body parts compared with the above-mentioned papers and as a consequence, the relative tumor density (RTD) has showed wide variations.…”

Facial skin cancers: general information and an overview of treatment methods

“…Incidence rate is 1.7%/year in the world [2] and in the Asian population [3]. In studies of Andrade 52.4% of non-melanoma cancers were found in women [4]. The most common of these is the basal-cell carcinoma (BCC) [5] and it is often not included in the registers, which causes skin cancers to occupy distant positions in them.…”