Prevalence of dermatologic disorders in 15 patients with acromegaly

Abstract

Acromegaly is a chronic, insidious and rare disease, caused by hyper secretion of the growth hormone, which metabolic and trophic effects commonly result in cutaneous manifestations, sometimes preceding other clinical symptoms. The authors have assessed 15 patients with acromegaly and found dermatologic lesions in all of them, mainly skin thickening, acrochordons, epidermoid cysts, pseudoacanthosis nigricans, seborrheic keratosis, melanocytic naevi and lentiginous spots.

Skin anomalies in acromegalic patients (Review of the practical aspects)

“…Most angiogenetic factors involve small vessel obstruction due to anomalies of lipid profile as seen in acromegaly (51). Oily aspect of the skin may be associated with keratosis, epidermoid cysts and crochordons and pseudo-acanthosis nigricans (52).…”

Dermatologic manifestations of acromegaly: A case in point and a focused review

“…These acanthosis nigricans changes can also be localized to the knee, ankle, and proximal and distal phalangeal and metocarpophalangeal joints [15]. Increased amounts of skin extracellular matrix, accompanied by edema, and alteration in the GAG quality cause these clinical findings [14,16].…”