Mulheres adultas com acne apresentam maior risco de elevação de triglicerídeos ao uso de isotretinoína oral

Schmitt, Juliano Vilaverde; Tavares, Mariana; Cerci, Felipe B.

doi:10.1590/s0365-05962011000400033

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…There has been an increased risk of elevated cholesterol and triglycerides and weight gain. 92,93 No changes were detected in serum androgens and insulin. 93…”

Section: Systemic Treatmentmentioning

confidence: 91%

Adult female acne: a guide to clinical practice

Bagatin

Freitas

Machado

et al. 2019

An. Bras. Dermatol.

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BackgroundAcne in women is often associated with anxiety and depression, and may persist from adolescence as well as manifest for the first time in adulthood. Genetic and hormonal factors contribute to its etiopathogenesis, and maintenance treatment is required, usually for years, due to its clinical evolution.ObjectiveTo develop a guide for the clinical practice of adult female acne.MethodsA team of five experts with extensive experience in acne conducted a literature review of the main scientific evidence and met to discuss the best practices and personal experiences to develop a guide containing recommendations for the clinical practice of adult female acne.ResultsThe group of specialists reached consensus on the main guidelines for clinical practice, providing detailed recommendations on clinical picture, etiopathogenesis, laboratory investigation and treatment of adult female acne.ConclusionDifferent from teenage acne, adult female acne presents some characteristics and multiple etiopathogenic factors that make its management more complex. This guide provides recommendations for best clinical practices and therapeutic decisions. However, the authors consider that additional studies are needed in order to provide more evidence for adult female acne to be better understood.

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“…There has been an increased risk of elevated cholesterol and triglycerides and weight gain. 92,93 No changes were detected in serum androgens and insulin. 93…”

Section: Systemic Treatmentmentioning

confidence: 91%

Adult female acne: a guide to clinical practice

Bagatin

Freitas

Machado

et al. 2019

An. Bras. Dermatol.

View full text Add to dashboard Cite

show abstract

Acne in Women

Handog

Macarayo

2022

Skin Diseases in Females

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Association of TNF-α polymorphisms (−857, −863 and −1031), TNF-α serum level and lipid profile with acne vulgaris

Younis

Shamim

Nisar

et al. 2021

Saudi Journal of Biological Sciences

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Background Acne is an inflammatory condition principally affected by genetic and dietary factors. Investigation into functional polymorphisms of TNF-α gene and their association with acne vulgaris will be helpful in exploring genetic influence on skin immune mediated inflammatory events. In the present study, we analyzed association of TNF-α gene polymorphisms, its expression levels and lipid profiles in a large cohort of acne patients and controls. Methods We used PCR-RFLP to study association of TNF-α polymorphisms at −857C/T, −863C/A and −1031 T/C sites with acne vulgaris. Lipid profiles were measured using enzymatic end-point method. The serum levels of TNF-α and apolipoprotein a were measured using ELISA. NIH, LDlink was used to investigate patterns of linkage disequilibrium across south Asian reference genome (Punjabi from Lahore Pakistan). Results We found that TNF-α −863 polymorphism is strongly associated with acne in overall population as well as in gender and severity based groups of acne patients. Polymorphisms at −863 and −1031 position were in linkage disequilibrium. Importantly, TNF-α serum level was significantly increased in acne patients with severe disease symptoms. Furthermore, levels of total cholesterol (TC) and triglycerides (TG) were significantly increased, whereas high density lipoprotein cholesterol (HDL-C) level was significantly decreased in acne patients. The levels of apolipoprotein a varied widely in studied populations and no significant difference was found in the analyzed groups. Conclusion In conclusion, we found that TNF-α expression increases in acne patients affected by TNF-α polymorphisms, and that the lipid profile is specifically disrupted in acne patients.

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Mulheres adultas com acne apresentam maior risco de elevação de triglicerídeos ao uso de isotretinoína oral

Cited by 6 publications

References 7 publications

Adult female acne: a guide to clinical practice

Adult female acne: a guide to clinical practice

Acne in Women

Association of TNF-α polymorphisms (−857, −863 and −1031), TNF-α serum level and lipid profile with acne vulgaris

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