Síndrome do desconforto respiratório agudo comocomplicação de psoríase pustulosa generalizada

Abstract

Since 1991, eight cases of pulmonary leak capilary syndrome have been described associated with pustular or erythrodermic psoriasis induced or not by the use of acitretin or sirolimus - being one of the cases, fatal. We report the case of a female patient with diagnosed GPP or von Zumbusch and multiple hospitalizations due to such condition. At that time, the condition was evolving with pulmonary onset and resolution with corticosteroids. The patient was not using any previously described medication that could precipitate pulmonary condition (methotrexate and acitretin). This is a rare complication associated with psoriasis which has not been described in Brazilian patients so far.

Acute Respiratory Distress Syndrome in a Carrier of an Interleukin-36 Receptor Antagonist Mutation With Generalized Pustular Psoriasis

“…To date, to our knowledge, there have been 15 reported cases of GPP or psoriatic erythroderma complicated with ARDS. [4][5][6] Our patient was treated with methotrexate in the year preceding the respiratory event, but the patient ceased receiving this medication several months prior to this event due to her anticipated pregnancy. Moreover, a normal baseline chest Xray and absence of circulating eosinophilia make methotrexate hypersensitivity quite unlikely in this setting.…”