2011
DOI: 10.1590/s0365-05962011000100012
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Abstract: BACKGROUND: The treatment of leprosy is defined by the classification of patients as paucibacillary (PB) or multibacillary (MB). The WHO (World Health Organization) classifies patients according to the number of lesions, but Ridley-Jopling (R & J) also uses complementary exams, which are difficult to use outside reference services. In 2003, a test called ML-Flow, an alternative to Elisa serology, was developed to help classify patients as PB or MB and decide about their treatment. OBJECTIVES: To assess the agr… Show more

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Cited by 25 publications
(23 citation statements)
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“…23,26 However, as PGL-1 antigen is not soluble in water, it remains in tissues for a long time, which stimulates the production of IgM antibodies in the absence of viable bacilli. 27 Therefore, the presence of anti-PGL-1 antibodies does not always mean active disease, since it may correspond to previous infection.…”
Section: Laboratory Diagnosismentioning
confidence: 99%
See 1 more Smart Citation
“…23,26 However, as PGL-1 antigen is not soluble in water, it remains in tissues for a long time, which stimulates the production of IgM antibodies in the absence of viable bacilli. 27 Therefore, the presence of anti-PGL-1 antibodies does not always mean active disease, since it may correspond to previous infection.…”
Section: Laboratory Diagnosismentioning
confidence: 99%
“…32 Thus, the investigation for IgM antibodies against PGL-1 should not be the only population screening tool to detect leprosy cases, but seropositive individuals should be followed up. 26,33 Notwithstanding, not all seropositive individuals will develop the disease. 28 …”
Section: Laboratory Diagnosismentioning
confidence: 99%
“…This simplified WHO classification was proposed in 1995 due to the local unavailability of tests required by the R&J criteria, such as histopathology, Mitsuda reaction, and skin smear microscopy. 14 …”
Section: Introductionmentioning
confidence: 99%
“…A vantagem desta estratégia diagnóstica seria a redução no desconforto do paciente, pois a coleta do material para baciloscopia é dolorosa e invasiva; e de custo, pois diminuiria a solicitação da bacterioscopia. Entretanto, note-se que a concordância do teste ML Flow com a baciloscopia nos pacientes MB varia entre 95,7% a 87,2%; e considerando ambos os grupos de pacientes, PB e MB, há uma variação de 70% a 66,7% 14,15,16,17 .…”
Section: Discussionunclassified