Importância da variação do PASI realizado por diversos observadores

Faria, Joana Ribeiro Costa de; Aarão, Aline Rezende; Jimenez, Luiz Miguel Zabaleta; Silva, Oscar Hernández; Avelleira, João Carlos Regazzi

doi:10.1590/s0365-05962010000500005

Cited by 38 publications

(18 citation statements)

References 7 publications

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“…Thus, the PASI can be inaccurate inter-individually and even show time-to-time variability in a single rater 3 5 . Therefore, expert training is required to minimize inter-rater and intra-rater variability in PASI assessment 6 . However, in actuality, most clinics do not provide residents with PASI assessment training.…”

Section: Introductionmentioning

confidence: 99%

Reduction of Inter-Rater and Intra-Rater Variability in Psoriasis Area and Severity Index Assessment by Photographic Training

et al. 2015

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BackgroundSeverity grading is important for the assessment of psoriasis treatment efficacy. This is most commonly achieved by using the psoriasis area and severity index (PASI), a subjective tool with inherent inter-rater and intra-rater variability. PASI-naive dermatologists require training to properly conduct a PASI assessment.ObjectiveIn the present study, we aimed to investigate whether photographic training improves inter-rater and intra-rater variabilities. We also determined which PASI component has the greatest impact on variability.MethodsTwenty-one dermatologists received 1 hour of PASI training. They were tested before and after the training to evaluate intra-rater variability. The physicians were further tested after training by using a reference photograph.ResultsThe mean of each PASI component was underevaluated compared with scoring by a PASI expert. The concordance rate with the expert's grading was highest for thickness followed by erythema, scaling, and area. The scaling score showed the greatest improvement after training. After training, the distribution of deviation from the expert's grading, which signifies inter-rater variability, improved only for the PASI area component. The deviation of scaling grading improved upon retesting by using a reference photograph.ConclusionPASI assessment training improved variabilities to some degree but not for every PASI component. The development of an objective psoriasis severity assessment tool will help overcome the subjective variabilities in PASI assessment, which can never be completely eliminated via training.

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Section: Introductionmentioning

confidence: 99%

Reduction of Inter-Rater and Intra-Rater Variability in Psoriasis Area and Severity Index Assessment by Photographic Training

et al. 2015

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“…Coefficients ≥0.7 represent good agreement and coefficients <0.5 represent mediocre or poor agreement. [24,25] The ICC was ≤0.45 in more than half the observations in our study.…”

Section: Discussionmentioning

confidence: 44%

Assessing practical skills in cardiopulmonary resuscitation

et al. 2017

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“…The inclusion criteria were as follows: patients did not receive systemic or local treatment with psoriasis drugs (including corticosteroids, immuno-suppressants and psoralen ultraviolet-A (PUVA) therapy) two months before enrollment; patients stopped using local glucocorticoids and other drugs for topical use for at least four weeks; patients had no systemic application of anti-psoriasis drugs, including oral corticosteroids, immunosuppressive agents, etc., for more than six weeks; and patients did not have accompanying heart, liver or kidney dysfunction or other systemic disorders. The severity of the disease in patients with psoriasis was determined in accordance with the psoriasis area and severity index (PASI), and the PASI scores of patients with psoriasis were recorded [25] The PASI scores of the patients with psoriasis were 8.3-46.9 (averaged 28.5).…”

Section: Methodsmentioning

confidence: 99%

Let-7a Inhibits T-Cell Proliferation and IFN-γ Secretion by Down-Regulating STAT3 Expression in Patients with Psoriasis

Xie

Chen

et al. 2017

Cell Physiol Biochem

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Objective: This study aimed to explore the effects of STAT3 targeting by let-7a on T-cell proliferation and IFN-γ secretion in psoriasis. Methods: From January 2013 to January 2015, 40 patients with psoriasis (psoriasis group) and 38 volunteers undergoing plastic surgery (control group) were enrolled in this study. Pearson correlation analysis was performed to evaluate the correlation between let-7a and STAT3 expression. T-cells were isolated and subjected to different transfection methods. A dual luciferase reporter assay was carried out to confirm STAT3 as a target gene of let-7a. Let-7a, STAT3 and IFN-γ mRNA expression was detected by quantitative real-time fluorescent polymerase chain reaction (qRT-PCR), and pSTAT3 protein levels were determined by Western blot. T-cell proliferation was evaluated with a cell counting kit-8 (CCK-8) assay. Results: The level of STAT3 mRNA and pSTAT3 was higher, but let-7a expression was lower in the psoriasis group than the control group. Pearson correlation analysis indicated that STAT3 expression was negatively correlated with let-7a expression. T-cells transfected with inhibitors exhibited greater IFN-γ mRNA expression and T-cell proliferation than transfected T-cells and T-cells transfected with a non-sense sequence, while T-cells transfected with let-7a mimics exhibited lower IFN-γ mRNA expression and T-cell proliferation than transfected T-cells and T-cells transfected with a non-sense sequence. This suggested that siRNA-STAT3 could reverse the increase in IFN-y mRNA expression and T-cell proliferation induced by let-7a inhibitors. Conclusion: Our results demonstrated that let-7a inhibits T-cell proliferation and IFN-γ secretion by down-regulating STAT3 in psoriasis.

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Importância da variação do PASI realizado por diversos observadores

Cited by 38 publications

References 7 publications

Reduction of Inter-Rater and Intra-Rater Variability in Psoriasis Area and Severity Index Assessment by Photographic Training

Reduction of Inter-Rater and Intra-Rater Variability in Psoriasis Area and Severity Index Assessment by Photographic Training

Assessing practical skills in cardiopulmonary resuscitation

Let-7a Inhibits T-Cell Proliferation and IFN-γ Secretion by Down-Regulating STAT3 Expression in Patients with Psoriasis

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