Manifestações cutâneas das trombofilias

Criado, Paulo Ricardo; Rivitti, Evandro A.; Vasconcellos, Cídia; Valente, Neusa Yuriko Sakai; Martins, José Eduardo

doi:10.1590/s0365-05962008000600002

Cited by 11 publications

(7 citation statements)

References 67 publications

(134 reference statements)

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“…Given the potential degree of morbidity and mortality that these conditions possess, clinical acumen with respect to cutaneous findings can provide an opportunity for proper diagnosis and treatment of these conditions [78,79].…”

Section: Discussionmentioning

confidence: 99%

Thrombophilia: the dermatological clinical spectrum

Criado¹,

Duarte²,

Magalhães³

et al. 2016

Glob Dermatol

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The aim of this article is to review the hypercoagulable states (thrombophilia) most commonly encountered by dermatologists, as well as their cutaneous signs, including livedo racemosa, cutaneous necrosis, digital ischemia and ulcerations, reticulated purpura, leg ulcers, and other skin conditions. Recognizing these cutaneous signs is the first step to proper treatment. Our aim is to describe which tests are indicated, and when, in these clinical settings.

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Section: Discussionmentioning

confidence: 99%

Thrombophilia: the dermatological clinical spectrum

Criado¹,

Duarte²,

Magalhães³

et al. 2016

Glob Dermatol

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“…7 Therapeutic regimens are suggested to maintain protein C levels stable during the critical period following initiation of warfarin use, with a low initial dose (1-2 mg/day) and daily increases of 1-2 mg/day until reaching the desired international normalized ratio (INR) in around 10 days. 8 Reports also suggest that interruption or continuation of warfarin treatment does not alter the cure or progression of the pressure ulcer. 8 The patient described in the present report presented risk factors for HIT and warfarin-induced skin necrosis: being female, elderly and obese.…”

Section: Discussionmentioning

confidence: 99%

“…8 Reports also suggest that interruption or continuation of warfarin treatment does not alter the cure or progression of the pressure ulcer. 8 The patient described in the present report presented risk factors for HIT and warfarin-induced skin necrosis: being female, elderly and obese. The use of high doses of coumarins was another predisposing factor for warfarin-induced skin necrosis.…”

Section: Discussionmentioning

confidence: 99%

Trombocitopenia induzida por heparina e necrose cutânea por varfarina: relato de caso

Kaiber

Malucelli

Baroni

et al. 2010

An. Bras. Dermatol.

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This paper describes a case of heparin-induced thrombocytopenia complicated by warfarininduced skin necrosis in a 74-year old female patient hospitalized with diagnoses of a hip fracture, deep vein thrombosis and pulmonary thromboembolism. Warfarin-induced skin necrosis is a rare complication of anticoagulant therapy, with high morbidity and mortality that may be associated with heparin-induced thrombocytopenia. Keywords: Heparin; Necrosis; Thrombocytopenia; Warfarin Resumo: É relatado um caso de trombocitopenia induzida por heparina complicada, com necrose cutânea induzida por varfarina em paciente de 74 anos, sexo feminino, internada com diagnóstico de fratura do colo do fêmur, trombose venosa profunda e tromboembolismo pulmonar. A necrose cutânea induzida por varfarina é uma complicação rara da terapia anticoagulante, com alta morbidade e mortalidade, que pode estar associada à trombocitopenia induzida por heparina.

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“…8 Several authors have used mini-doses of heparin or even full dose anticoagulation. 8,[19][20][21]32,43,45,48,67,[92][93][94][95] Both unfractionated heparin (UFH) and low molecular weight heparins (LMWHs) have established employment in the prevention and treatment of venous thromboembolism (VTE) and as adjunctive therapy in atheroembolic syndromes. 96 LMWHs are replacing UFH in anticoagulation therapy due to a number of advantages, which include a more predictable pharmacokinetic profile and ease of use.…”

Section: (Vi) Therapies Of Still Poorly Understood Mechanismsmentioning

confidence: 99%

Vasculopatia livedoide: uma doença cutânea intrigante

Criado

Rivitti

Sotto

et al. 2011

An. Bras. Dermatol.

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Livedoid vasculopathy is a skin disease that occludes the blood vessels of the dermis. It has a pauciinflammatory or non-inflammatory nature. It is characterized by the presence of macular or papular, erythematous-purpuric lesions affecting the legs, especially the ankles and feet, and producing intensely painful ulcerations, which cause white atrophic scars called "atrophie blanche". This review includes studies and case reports found in the medical literature regarding the etiopathogenic associations of the disease, particularly those related to thrombophilia, their histopathological findings and the therapeutic approaches used in the difficult clinical management of these cases. Keywords: Leg ulcer; Livedo reticularis; Thrombophilia; Thrombosis; Venous thrombosis Resumo: A vasculopatia livedoide é uma afecção cutânea oclusiva dos vasos sanguíneos da derme, de caráter pauci-inflamatório ou não-inflamatório. Caracteriza-se pela presença de lesões maculosas ou papulosas, eritêmato-purpúricas, nas pernas, especialmente nos tornozelos e pés, as quais produzem ulcerações intensamente dolorosas, que originam cicatrizes atróficas esbranquiçadas, denominadas "atrofia branca". Nesta revisão, abordamos os estudos e relatos de caso da literatura médica referentes às associações etiopatogênicas da doença, particularmente as que se referem aos estados de trombofilia, seus achados histopatológicos e abordagens terapêuticas empregadas na difícil condução clínica destes casos.

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Manifestações cutâneas das trombofilias

Cited by 11 publications

References 67 publications

Thrombophilia: the dermatological clinical spectrum

Thrombophilia: the dermatological clinical spectrum

Trombocitopenia induzida por heparina e necrose cutânea por varfarina: relato de caso

Vasculopatia livedoide: uma doença cutânea intrigante

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