Atividades de substâncias isoladas de liquens sobre formas promastigotas de Leishmania (L.) amazonensis e Leishmania (V.) brasiliensis

Urdaplleta, Ada Amélia Ayala

doi:10.1590/s0365-05962008000200016

Cited by 2 publications

(2 citation statements)

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“…However, all species of the genus Ramalina contain usnic acid in variable concentration [5,39]. Studies of the isolation and biological activity tests of the compound have presented, almost always, unexpected results, generating numerous publications [5,7,10,12,13,16,21,25,26,27,28,29,34,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Chemistry and Biological Activity of Ramalina Lichenized Fungi

et al. 2015

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Lichens are a form of symbiont between a fungus and an alga or cyanobacterium, which contains a wide variety of organic compounds with certain secondary metabolite classes typical of these organisms. The Ramalina genus has approximately 246 species distributed around the World, of which in this review approximately 118 species with published chemical or biological activity studies of extracts or isolated compounds were cited. From the 153 mentioned compounds, only 27 passed were tested for biological activity, being usnic acid the most studied compound and the one showing the best results in almost all in vitro tests performed, although other compounds also presented excellent results as antimicrobial, antitumor and anti-inflammatory agents, among others. Extracts of several species also presented significant results in performed biological tests, demonstrating the potential that these organisms have, in particular, the gender Ramalina, to produce bioactive molecules that can be used as a model for the production of pharmaceuticals.

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Section: Chemical Constituentsmentioning

confidence: 99%

Chemistry and Biological Activity of Ramalina Lichenized Fungi

et al. 2015

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“…99 Maesa balansae, planta vietnamita, teve excelente resultado na LV e LC experimentais, porém, toxicidade inaceitável. 101 Três substâncias extraídas do líquen, β-metil orselinato de metila, orselinato de n-butila e orselinato de n-propila foram leishmanicidas para L.( L.) a. e L.(V.) b., in vitro, sendo a última mais eficaz. 102 Novas dermaseptinas (peptídeos) extraídos da Phyllomedusa hypochondrialis (Amphibia) foram mais efetivas que o SbV na lise de promastigotas de L. (L.) a.…”

Section: Bifosfonatosunclassified

Tratamento da Leishmaniose Tegumentar Americana

Lima

Porto

Motta

et al. 2007

An. Bras. Dermatol.

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A leishmaniose tegumentar americana é doença infecciosa da pele e mucosa, cujo agente etiológico é um protozoário do gênero Leishmania. Seu tratamento é desafio porque as drogas disponíveis apresentam elevada toxicidade, e nenhuma delas é bastante eficaz. A recidiva, a falha terapêutica em pacientes imunodeprimidos e a resistência ao tratamento são fatores que motivam a busca de uma droga ideal.

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Atividades de substâncias isoladas de liquens sobre formas promastigotas de Leishmania (L.) amazonensis e Leishmania (V.) brasiliensis

Abstract: Atividades de substâncias isoladas de liquens sobre formas promastigotas de Leishmania (L.) amazonensis e Leishmania (V.) brasiliensis. Dissertação de Mestrado defendida em 2006.

Cited by 2 publications

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Chemistry and Biological Activity of Ramalina Lichenized Fungi

Chemistry and Biological Activity of Ramalina Lichenized Fungi

Tratamento da Leishmaniose Tegumentar Americana

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