Síndrome de Sweet asociado a neoplasias

Abstract

Sweet's syndrome was described in 1964 by Robert Douglas Sweet, as an entity he named acute febrile neutrophilic dermatosis. It is characterized by five main features: 1) sudden appearance of erythematous and tender plaques on the face, neck and extremities; 2) fever; 3) polymorphonuclear leukocytes; 4) predominantly neutrophilic dense infiltrate in the dermis, and 5) rapid response to steroid therapy. Sweet's syndrome can be classified into five groups: idiopathic, parainflammatory, paraneoplastic, drug-induced, and pregnancy-related. Twenty percent of cases are associated with malignancies; 85% out of them involve hematologic alignancies and the remaining 15%, solid tumors. A series of seven cases of Sweet's syndrome associated with neoplasms which were diagnosed from 2002 to 2006 is presented. Six cases were related to oncohematologic diseases and one to solid tumors. These results highlight the importance of the diagnosis of the syndrome, since it may predict tumor relapse or underlying disease progression. The timely use of diagnostic and treatment methods may improve the quality of life of these patients. The fact that oncology patients take multiple medications (a colony-stimulating factor) which may be associated with the onset of this entity must also be considered in excluding possible causes. Keywords: Prognosis; Skin Neoplasms; Sweet's syndrome

Síndrome de Sweet: estudo de 73 casos, com ênfase nos achados histopatológicos

“…Sweetís syndrome may be associated with a malignancy in as many as 20% of cases and the skin manifestation may either precede or follow manifestation of the malignancy. 10,11 In the present sample, however, neoplasia (Hodgkinís lymphoma) was found in only one case (1.5%). In this case, the diagnosis of lymphoma preceded that of Sweetís syndrome and no recurrence has been recorded.…”

“…The association between Sweetís syndrome and leukemia is well-known and corresponds to the majority of cases of malignancy; however, lymphoma is rare. [10][11][12][13][14][15] The association between Hodgkinís lymphoma and Sweetís syndrome is even rarer. To the best of our knowledge, this is only the fifth report of such a case.…”

Síndrome de Sweet associada à policitemia vera

“…A SS está relacionada a neoplasias em 20% dos casos, 3,6 sendo que 85% destes estão relacionados a transtornos hematológicos e 15%, a tumores sólidos. Em relação às neoplasias hematológicas, é mais frequentemente observada a leucemia mieloide aguda; quanto aos tumores sólidos, 2/3 correspondem a carcinomas do trato geniturinário.…”

“…Em relação às neoplasias hematológicas, é mais frequentemente observada a leucemia mieloide aguda; quanto aos tumores sólidos, 2/3 correspondem a carcinomas do trato geniturinário. 3 A forma paraneoplásica da SS acomete igualmente homens e mulheres com idades entre 60 e 70 anos, diferentemente da forma clássica. As manifestações clínicas podem ser mais graves e atípicas do que nesta, com presença de pústulas, bolhas, úlceras e púrpuras.…”

“…Corticoides sistêmicos são a terapêutica de escolha e determinam rápida resposta clínica. [3][4][5] A SS pode estar associada a malignidades em 20% dos casos, 3,6 em especial, a leucemia mieloide aguda. Existem poucos relatos de associação com a policitemia vera.…”