Modulação da proliferação fibroblástica e da resposta inflamatória pela terapia a laser de baixa intensidade no processo de reparo tecidual

Júnior, Adeir Moreira Rocha; Oliveira, Rodrigo Guerra de; Farias, Rogério Estevam; Andrade, Luiz Carlos Ferreira de; Aarestrup, Fernando Monteiro

doi:10.1590/s0365-05962006000200006

Cited by 72 publications

(40 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…and Araújo et. al., (19,20) indicated that phototherapy promotes increased cell and collagen proliferation and accelerated the process of wound epithelialization.…”

Section: Discussionmentioning

confidence: 99%

Effects of low level laser therapy on the cicatricial dehiscence in the postoperative period of lipoabdominoplasty. Case Report

Roque¹,

Silva²,

Sousa³

et al. 2020

mtprehabjournal

View full text Add to dashboard Cite

Introduction:The surgical procedure is used for the treatment of external and internal injuries and diseases, performed through operations. In this context, the plastic surgery has the purpose of artificially reconstructing a part of the body. Among the various types of surgical interventions, lipoabdominoplasty is more accomplished, correcting the aesthetic and functional deformities of the abdomen, adding a better and more harmonious abdominal contour. Objective: To analyze the effect of the application of the low power laser in the repair of the cicatricial dehiscence in the postoperative period of lipoabdominoplasty in one patient. Methodology: A 25-year-old female patient who underwent lipoabdominoplasty surgery sought physical therapy in March 2017. She had cicatricial dehiscence, and started the pharmacological and physiotherapeutic treatment with low-power laser, AsGa, 12 s, 6J, non-contact. Results: It was observed improvement of the dehiscence progressively, with reduction of the local inflammation, reorganization of the tissue and closure of the wound, presenting in the end only the surgical scar. Conclusion: This study demonstrated positive effect of laser therapy, recovering the injured tissue, signaling a new non-invasive approach to a safe and beneficial treatment.

show abstract

“…and Araújo et. al., (19,20) indicated that phototherapy promotes increased cell and collagen proliferation and accelerated the process of wound epithelialization.…”

Section: Discussionmentioning

confidence: 99%

Effects of low level laser therapy on the cicatricial dehiscence in the postoperative period of lipoabdominoplasty. Case Report

Roque¹,

Silva²,

Sousa³

et al. 2020

mtprehabjournal

View full text Add to dashboard Cite

show abstract

“…Entretanto, a análise histomorfométrica revelou que a redução da intensidade do infiltrado inflamatório e a indução do processo de reparação tecidual não foram estatisticamente significativas quando comparadas aos dados obtidos das amostras cutâneas dos animais do grupo controle. Estes dados são diferentes dos estudos anteriores 6,8,36 que demonstram significância estatística no potencial anti-inflamatório e pró-cicatricial da LLLT em animais convencionais 8,37,38 . Estes estudos acima mencionados reportam a hipótese de que o desenvolvimento do diabetes interfere substancialmente com a resposta inflamatória e cicatricial.…”

Section: Discussionunclassified

“…Novas possibilidades terapêuticas estão sendo preconizadas utilizando a terapia laser de baixa intensidade (LLLT) no processo de reparo tecidual. Esta terapia demonstra ser um recurso eficaz na diminuição do tempo de reposição tecidual, ou seja, melhora a qualidade da reparação tecidual e acelera o processo de cicatrização [6][7][8][9] . Modelos experimentais de diabetes em murinos estão sendo amplamente estudados a fim de esclarecer o mecanismo fisiopatológico da doença.…”

Section: Introductionunclassified

Inibição da expressão de ciclooxigenase 2 em feridas cutâneas de camundongos NOD submetidos à terapia a laser de baixa intensidade

Rocha

Júnior²,

Aarestrup

et al. 2012

J. vasc. bras.

Self Cite

View full text Add to dashboard Cite

ResumoContexto: A terapia a laser de baixa intensidade (LLLT) tem sido relatada como importante moduladora da cicatrização de feridas cutâneas aumentando a proliferação fibroblástica associada ao aumento da expressão da citocina fator transformador de crescimento-β2 (TGF-βB2). Objetivo: No presente estudo foram avaliados os efeitos da LLLT sobre a expressão da enzima ciclooxigenase 2 (COX2) no sítio do reparo tecidual utilizando o modelo experimental com camundongos diabéticos não obesos (NOD) para estudar a cicatrização de feridas cutâneas. Métodos: Foram utilizados 30 camundongos NOD, destes 14 ficaram diabéticos e foram divididos em dois grupos: o grupo I (n=7) foi submetido a um procedimento cirúrgico de feridas cutâneas e o grupo II (n=7) foi submetido a um procedimento cirúrgico de feridas cutâneas e tratados com LLLT. O grupo II foi submetido à LLLT nos seguintes parâmetros: 15 mW de potência, dose de 3,8 J/cm 2 e tempo de aplicação de 20 segundos. Após sete dias do ato cirúrgico e após aplicação do laser, os animais foram eutanasiados com sobredose de anestesia e amostras das feridas foram colhidas para posterior análise histopatológica, histomorfométrica e imuno-histoquímica. Resultados: A LLLT promoveu a inibição da expressão da COX2 em feridas cutâneas de camundongos diabéticos. Conclusão: Em conjunto, os resultados sugeriram que a LLLT é capaz de modular negativamente a expressão da enzima COX2 contribuindo para o controle da resposta inflamatória em feridas cutâneas de camundongos NOD.Palavras-chave: camundongos endogâmicos NOD; ciclooxigenase 2; terapia a laser de baixa intensidade. AbstractBackground: Low-level laser therapy (LLLT) has been reported to modulate the healing of wounds by inducing an increase in fibroblast number associated with increased expression of the cytokine transforming growth factor-β 2 (TGF-β 2 ). Objective: In the present study, the effect of LLLT on expression of COX2 at the site of tissue repair was evaluated, using an experimental model with non obese diabetic mice (NOD) to study cutaneous wound healing. Methods: Thirty NOD mice were used, of which 14 were diabetic and were divided into two groups: group I (n=7) underwent a surgical procedure of skin wounds and group II (n=7) underwent a surgical procedure of skin wounds and treated with LLLT. Group II was submitted to LLLT in the following parameters: 15 mW of power, dose of 3.8 J/cm 2 and exposure time of 20 seconds. Seven days after surgery and after laser application, animals were euthanized with an overdose of anesthesia and tissue samples were collected for subsequent histological analysis, histomorphometry and immunohistochemistry. Results: The LLLT has promoted the inhibition of COX2 expression in skin wounds in mice diabetic. Taken together the results suggest that LLLT modulate the expression of COX2 improved the control of inflammatory reaction in cutaneous wound lesions in NOD mice. Conclusion: Taken together, the results suggested that LLLT is able to negatively modulate the expression of COX2 enzyme contri...

show abstract

“…The low intensity laser therapy (LLLT) is a generic term that defines the application of laser therapy with relatively low power (less than 500mW) 2 . Effects of low intensity laser on healing have been developed, checking analgesic, antiinflammatory and healing [3][4][5] , although many studies don't show the specific type of laser used, refer only to such as laser 600nm 5 .…”

Section: Introductionmentioning

confidence: 99%

Healing activity of laser InGaAlP (660nm) in rats

Tacon¹,

Santos²,

Parente³

et al. 2011

Acta Cir. Bras.

View full text Add to dashboard Cite

PuRPOsE: To evaluate the effect the healing activity of diode laser Indium Gallium Aluminum Phosphorus (InGaAlP) ë660nm on healing of surgical wounds in rats.METHOds: Fifty-four female Wistar rats were used, divided into three groups (n=18) and subdivided into three subgroups (n=6) to be studied in 5, 10 and 15 th days after surgical procedures. The wound was induced in the dorsal-cervical using punch. The lesions were irradiated on alternate days with InGaAlP laser, the energy densities of 3J/cm 2 (L3) or 6J/cm 2 (L6). The control group received no irradiation. At 5, 10 and 15 th days after surgery the animals were euthanized and the repair area was removed and histological sections were stained with hematoxylin-eosin and picrossírius. We evaluated macroscopic and histological lesions in the times cited, as well as morphometric analysis of angiogenesis and collagen content. REsuLTs:The wound healing activity InGaAlP laser was evidenced by increased angiogenesis group L3 and L6 in relation to control group (CG) at the 5 th day (p=0.0001) and decreased polymorphonuclear infiltrate and hemorrhage (p=0.045 and p=0.07 respectively) in the groups L3 and L6 in relation to control group (GC). On the 10 and 15 th days was also observed in groups treated with laser L3 and L6 stimulation was pronounced fibroplasia (p=0.0003 and p=0.034 respectively) when compared with the control group (CG). CONCLusION:The InGaAlP laser acted positively on the healing of skin wounds in rats.Keywords: Wound Healing. Laser Therapy, Low Intensity. Rats. REsuMOOBJETIVO: Avaliar a atividade cicatrizante do laser diodo Alumínio Gálio Índio Fósforo (AlGaInP), ë660nm em feridas cutâneas induzida em ratos. MéTOdOs:Foram utilizados 54 ratos Wistar, fêmeas, divididos em três grupos (n=18) e subdivididos em três subgrupos (n=6) animais para serem estudados no 5, 10 e 15° dias após o procedimento cirúrgico. A ferida foi induzida em região dorso-cervical utilizando punch.

show abstract

Modulação da proliferação fibroblástica e da resposta inflamatória pela terapia a laser de baixa intensidade no processo de reparo tecidual

Cited by 72 publications

References 22 publications

Effects of low level laser therapy on the cicatricial dehiscence in the postoperative period of lipoabdominoplasty. Case Report

Effects of low level laser therapy on the cicatricial dehiscence in the postoperative period of lipoabdominoplasty. Case Report

Inibição da expressão de ciclooxigenase 2 em feridas cutâneas de camundongos NOD submetidos à terapia a laser de baixa intensidade

Healing activity of laser InGaAlP (660nm) in rats

Contact Info

Product

Resources

About