Borreliose de Lyme simile: uma doença emergente e relevante para a dermatologia no Brasil

Fonseca, Adivaldo Henrique da; Salles, Roberto de Souza; Salles, Simone de Abreu Neves; Madureira, Renata Cunha; Yoshinari, Natalino Hajime

doi:10.1590/s0365-05962005000200008

Cited by 20 publications

(20 citation statements)

References 35 publications

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“…Also, skin lesions are not restricted to the presence of EM or annular secondary lesion. Localized scleroderma-like lesion, benign B lymphocytoma, acrodermatitis chronica atrophicans (ACA) and panniculitis have been described in Brazil 15,47 . All these symptoms already identified in BYS, must be remembered by Brazilian physicians when they are performing a patient's anamnesis and physical examination.…”

Section: Discussionmentioning

confidence: 99%

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Gouveia

Alves

Mantovani

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe aim of this study was to evaluate the epidemiological, clinical and laboratorial profile of patients with Baggio-Yoshinari Syndrome (BYS), who underwent internment at the Instituto de Infectologia Emilio Ribas in São Paulo, Brazil, during the period from July 1990 to July 2006. BYS is a new Brazilian tick-borne disease caused by Borrelia burgdorferi sensu lato microorganisms that resembles features of Lyme disease (LD), except for its epidemiological, clinical and laboratorial particularities. From 60 patients' records with positive serology to B. burgdorferi done by ELISA and Western-blotting methods, 19 cases were diagnosed as having BYS, according to criteria adopted at LIM-17 HCFMUSP, the Brazilian Reference Laboratory for the research of BYS. The other 41 remaining patients displayed miscellaneous infections or auto-immune processes. The beginning of symptoms in BYS group varied from one day to six years, from the onset of the disease. Four of 19 patients were included in acute disease stage, and 15 in latent. General unspecific symptoms were identified in almost all cases, with high frequencies of fever (78.9%) and lymphadenomegaly (36.8%). Six patients had skin lesions (31.5%); six arthralgia or arthritis (31.5%) and eight neurological symptoms (42%). Interestingly, two patients showed antibodies directed to B. burgdorferi exclusively in cerebrospinal fluid. Since BYS is a new emergent Brazilian zoonosis and its diagnosis is sometimes complex, all the new knowledge about BYS must be scattered to Brazilian Medical specialists, aiming to teach them how to diagnose this amazing tick-borne disease and to avoid its progression to chronic irreversible sequels.

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Section: Discussionmentioning

confidence: 99%

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Gouveia

Alves

Mantovani

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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“…The present study found adherence and development of spirochetes to the cells of R. microplus and A. cajennense. The development of this type of study is important because these ticks are involved in the transmission of spirochetes of the genus Borrelia in Brazil (Fonseca et al, 2005;Mantovani et al, 2007;Yoshinari et al, 2010). Rezende et al (2008) demonstrated the occurrence of Borrelia spp.…”

Section: Discussionmentioning

confidence: 99%

Primary embryonic cells of Rhipicephalus microplus and Amblyomma cajennense ticks as a substrate for the development of Borrelia burgdorferi (strain G39/40)

Rezende

et al. 2012

Braz. J. Biol.

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Borrelia burgdorferi, the agent of Lyme borreliosis, is a spirochetes transmitted by ticks to humans and animals. Its cultivation in vitro in tick cells allows studies of its biology and provides methodology for future research in Brazil, and for the isolation of Borrelia spp. We examined in vitro the characteristics of embryonic cells of Rhipicephalus microplus and Amblyomma cajennense in cell culture and investigated the suitability of embryonic cells as a substrate for cultivation of B. burgdorferi. Subcultures were prepared from primary cultures of embrionary cells of R. microplus and A. cajennense maintained in Leibovitz's (L-15) complete medium at 28 °C and 31 °C, respectively. When a monolayer had formed, the L-15 was replaced with Barbour-Stoener-Kelly medium for experiments to infect cell cultures with B. burgdorferi. After 72 hours of cultivation, the spirochetes were counted using an inverted phase contrast microscope and dark-field illumination (400×). Survival, multiplication and the adherence of B. burgdorferi for embryonic cells of R. microplus and A. cajennense were observed. B. burgdorferi cultured with embryonic cells of R. microplus grew on average to a density (final count) of 2.4 × 10 7 spirochetes/mL, whereas in cell-free culture, an average of 2.5 × 10 7 spirochetes/mL were counted. When cultivated with A. cajennense cells, the final count of spirochetes was on average 1.7 × 10 7 spirochetes/mL, while spirochetes cultured under cell-free conditions replicated on average of 2.

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“…Estes microrganismos apresentam distribuição global e já foram descritos para-sitando diversos grupos de aves em praticamente todas as regiões geográficas (Fudge 2000, Santos-Prezoto et al 2004, Fonseca et al 2005, Lisbôa et al 2008, Fecchio 2011. Dentre os parasitos, chama-se atenção para o gênero Plasmodium (Marchiafava & Celli, 1885), causador da malária aviária, que até 2005, foi registrado em 13,5% da avifauna mundial analisada para hemoparasitos.…”

Section: Introductionunclassified

“…No mundo, a borreliose aviária é ocasionada por Borrelia anserina, que delineia um quadro clínico inicial de hipertermia e polidipsia, sonolência, inapetência, diarreia verde-escura, com evolução para cianose com hipotermia, podendo ocorrer transtornos paralíticos e morte (Fonseca et al 2005, Ataliba et al 2007, Lisbôa et al 2008.…”

Section: Introductionunclassified

Parasitismo em aves silvestres residentes e migratórias da Ilha da Marambaia, Estado do Rio de Janeiro1

et al. 2016

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ABsTRACT.-Brum W.M., Da Costa Pereira M.A.V., Vita G.F., Ferreira I., Mello E.R., Aurnheimer R.C.M., Sanavria A. & Padua E.D. 2016 The study intended to analyze the population of migratory and resident wild bird species from Marambaia island, located in the municipality of Mangaratiba, Rio de Janeiro state, regarding the presence of microorganisms in blood smears during the year of 2009. In order to achieve the goal, 86 individuals of 22 bird species were captured using mist nets; peripheral blood was collected and blood smears performed. The birds were released after examined and sampled in situ. The diagnostic results were 11 (12.80%) birds positive for Plasmodium sp., one (1.16%) for microfilaria and 16 (18.60%) for Borrelia sp. Ticks identified as Amblyomma sp. (Ixodidae) were observed parasiting the sampled birds, suggesting that a relationship parasite-vector-host exists between these ticks and the Borrelia genus. This study should be expanded to other regions so that its results may favour other surveys, focused on conservation of wild birds in their habitat.

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Borreliose de Lyme simile: uma doença emergente e relevante para a dermatologia no Brasil

Cited by 20 publications

References 35 publications

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Primary embryonic cells of Rhipicephalus microplus and Amblyomma cajennense ticks as a substrate for the development of Borrelia burgdorferi (strain G39/40)

Parasitismo em aves silvestres residentes e migratórias da Ilha da Marambaia, Estado do Rio de Janeiro1

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