Manifestações tegumentares da doença enxerto contra hospedeiro em pacientes transplantados de medula óssea

Abstract

Graft-versus-host disease (GVHD) is a systemic disease that occurs in patients that receive immunocompetent lymphocytes. Pathophysiology involves an immunologic reaction between transplanted lymphocytes and tissues of the host, through an immune attack of donor T cells against recipient cells that differ from the donor's by histocompatibility antigens. It is a major complication of allogeneic hematopoietic stem cell transplantation. GVHD skin involvement is frequent and contributes to morbidity and mortality of bone marrow transplantation. Dermatologists have an important role on patient´s evaluation, providing early diagnosis of GVHD disease and its complications, so as to follow-up these patients. In this review, we emphasize the skin manifestations of GVHD, taking into account our 14-year personal experience at Centro Nacional

PCR diagnostics and monitoring of adenoviral infections in hematopoietic stem cell transplantation recipients

“…Local infection was limited to detection of AdV genome at one body site. Acute GvHD was graded as grades 0 to IV according to standard criteria [29]. Mild acute GvHD was defined as grades I–II, and severe, as III–IV.…”

Acute Hair Loss 3 Years after Bone Marrow Transplant

“…Recently, cicatricial alopecia of the scalp was reported in a case of GVHD in which the patient had features of female-pattern hair loss and lichen planus pilaris. This condition is known as fibrosing alopecia in a pattern distribution [3]. …”

Ação dos linfócitos T regulatórios em transplantes

“…Linfócitos T citotóxicos CD8 + predominam no infiltrado e podem, diretamente, induzir o dano tecidual, porém outras células efetoras (células NK, macrófagos e mastócitos) e citocinas (TNF-α) podem mediar a citotoxicidade. 54…”