Hiperplasia angiolinfóide com eosinofilia: relato de dois casos

Abstract

Resumo: Os autores apresentam dois casos de hiperplasia angiolinfóide com eosinofilia, doença relativamente rara. Uma das pacientes apresentava lesões exuberantes e de localização incomum, já que é em geral situada na cabeça e/ou no pescoço. A histopatologia corada com HE e a imuno-histoquímica com fator VIII confirmaram o diagnóstico e a origem endotelial das lesões de ambas as pacientes. Palavras-chave: eosinofilia; hiperplasia angiolinfóide com eosinofilia. Summary: The authors present two cases of the relatively uncommon disease angiolymphoid hyperplasia with eosinophilia, which is usually located on the head and/or neck. One of the patients showed exuberant lesions and unusual site. Histopathology with HE and immunohistochemistry with factor VIII confirmed the diagnosis and the endothelial origin in both cases.

Angiolymphoid hyperplasia with eosinophilia versus Kimura's disease: a case report and a clinical and histopathological comparison

“…There seems to be a higher incidence in females and lesions are more common in patients aged 20-50 years. 2 4. …”

“… 5 - 7 Some recent studies tend to consider it as a vascular malformation secondary to a subcutaneous arteriovenous shunt, but the hypothesis most widely accepted is that it is a reactive vascular hyperplasia to various stimuli. 1 , 4 …”

“…Because of their similarities, these two conditions were initially considered two outcomes of the same disease. 2 - 4 Although recent articles have established consistent differentiation criteria, there are still differences in the understanding of the two entities.…”

Hiperplasia angiolinfoide como causa de eosinofilia

“…Contudo, há casos em que há recidiva e, nestes, alguns tratamentos propostos são: criocirurgia com nitrogênio líquido, radioterapia local ou injeções intralesionais de corticoide. 9,12,13,14 Existem casos relatados de regressão espontânea. 15 Há muita confusão na literatura médica para a distinção entre Hale e doença de Kimura.…”

Caso para diagnóstico

“…[2][3][4][5] The treatment of ALHE, reserved for symptomatic and disfiguring cases, is considered a challenge, with multiple possible forms of management of varying success, ranging from topical treatments (tacrolimus, imiquimod), intralesional treatments (interferon, corticotherapy) and oral treatments (corticotherapy, retinoids). 4,6 Cases of spontaneous regression have been reported. Surgical excision is considered one of the most effective options; however, recurrence of the lesions occurs in around one-third of cases.…”