Nevo melanocítico congênito

Paschoal, Francisco Macedo

doi:10.1590/s0365-05962002000600002

Cited by 7 publications

(11 citation statements)

References 22 publications

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“…Malignant melanoma is a rare tumor during childhood and accounts for up to 0.9% of all pediatric malignancies [1, 2]. A congenital melanocytic nevus (CMN) is clinically defined as a melanocytic lesion that is present at birth or develops during infancy from preexistent melanocytes [3–5]. CMNs typically affect the trunk and proximal parts of the limbs, scalp, and neck, but might involve any other skin surface.…”

Section: Introductionmentioning

confidence: 99%

Melanoma arising in a Giant congenital melanocytic nevus: two case reports

et al. 2019

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Background A giant congenital melanocytic nevus (GCMN) is found in 0.1% of live-born infants. If present, the lesion has a chance of about 6% to develop into malignant melanoma. Both children and adults can be affected by malignant melanoma arising in a giant congenital nevus. Up to 95% of GCMNs harbor NRAS mutations, and mutations in the BRAF , MC1R , TP53 , and GNAQ genes have also been described. The individualization of therapy is required, but diagnostic and prognostic criteria remain controversial. Case presentations We report two cases: 1) melanoma arising in a giant congenital nevus during the first month of life complicated with neurocutaneous melanosis (NCM), and 2) melanoma arising in a giant congenital nevus during the first 6 months of life. Pathology, immunohistochemistry, and genetic analyses of tumor tissue were performed. The first case revealed only a non-pathogenic P72R polymorphism of the TP53 gene in the homozygote condition. For the second case, a Q61K mutation was detected in the NRAS gene. Conclusion Malignant melanoma associated with GCMN is rare and therefore poorly understood. Outcomes have been linked to the stage at diagnosis, but no additional pathological prognostic factors have been identified. The most frequent genetic event in giant CMNs is NRAS mutations, which was discovered in one of our cases. To accumulate evidence to improve disease prognosis and outcomes, children with congenital melanocytic nevus should be included in a systemic follow-up study from birth.

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Section: Introductionmentioning

confidence: 99%

Melanoma arising in a Giant congenital melanocytic nevus: two case reports

et al. 2019

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“…1-3 Histologically, it is characterized by the presence of melanocytes between collagen bundles at the reticular dermis and around adnexal structures.…”

Section: Introductionmentioning

confidence: 99%

Melanoma associated with congenital intermediate common blue nevus of the scalp - Case report

Ribeiro

Serpa

Sousa

et al. 2016

An. Bras. Dermatol.

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Melanomas can arise either de novo (70%) or from pre-existing melanocytic lesions (30%). Of the latter, most cases arise at the dermoepidermal junction from small congenital or acquired non-blue nevi while only a few arise from blue nevi, notably the cellular subtype and less commonly the common (dendritic) type. Melanomas that arise from blue nevi usually occur on the scalp with greater frequency, as in the case described. Although previous studies have discussed melanoma arising from giant congenital blue nevi, few have discussed those arising from intermediate blue nevi. We present a case of a 52-yearold man with melanoma on the scalp evolving from an intermediate congenital common blue nevus.

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“…Sendo estabelecido que: pequeno (< 1,5 cm de diâmetro), médio (1,5 cm -20 cm no maior diâmetro) e gigante (> 20 cm de diâmetro). Podem ainda ser lisos ou elevados, com coloração variando entre o castanho claro e o escuro, uniformes e com bordas definidas, com ou sem pelos (os com pelos são denominados nevos pilosos gigantes) 2 .…”

Section: Introductionunclassified

“…As lesões classificadas como pequenas e médias são relativamente comuns, representam cerca de 1% dos nascimentos 1 , ao passo que o nevo gigante é uma condição rara, cuja incidência está estimada em 1 para cada 20 mil nascimentos. Está é a classificação adotada neste trabalho, por ser utilizada em trabalhos que estudam o risco de surgimento de melanoma 2,3 .…”

Section: Introductionunclassified

Tratamento cirúrgico do nevo melanocítico gigante

Carneiro¹,

Aguiar²,

Pitanguy³

2011

Rev. Bras. Cir. Plást. (Impr.)

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Carneiro Junior LVF et al. Tratamento cirúrgico do nevo melanocítico gigante Surgical treatment of giant melanocytic nevi RESUMO O nevo melanocítico congênito está presente em aproximadamente 1% dos recém nascidos. As lesões classificadas como pequenas e médias são relativamente comuns, e possuem risco de degeneração maligna baixo. Por outro lado, as lesões chamadas de gigantes são raras e possuem maior risco de malignização. Neste trabalho é relatada a experiência do autor, no tratamento cirúrgico dos nevos melanocíticos gigantes. Descritores: Nevo. Melanoma. Dispositivos para Expansão de Tecidos.

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Nevo melanocítico congênito

Cited by 7 publications

References 22 publications

Melanoma arising in a Giant congenital melanocytic nevus: two case reports

Melanoma arising in a Giant congenital melanocytic nevus: two case reports

Melanoma associated with congenital intermediate common blue nevus of the scalp - Case report

Tratamento cirúrgico do nevo melanocítico gigante

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