2002
DOI: 10.1590/s0104-79302002000200003
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Abstract: Lethal Toxin Neutralizing Factor (N-LTNF), MW 63.0 kDa, was isolated from opossum serum. After trypsin digestion, the active domain of N-LTNF was isolated and sequenced. The synthetic peptide consisting of ten amino acids was designated as LT-10. N-LTNF and LT-10 inhibited the lethality of animal, plant and bacteria toxins when tested on mice non-immunologically. The antibodies against N-LTNF and LT-10 only reacted immunologically with toxins and not with non-toxic substances. Anti-LTNF and anti-LT-10 reacted … Show more

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“…According to Pore et al [ 22 ], in vivo assays are extremely imperative because they permit researchers to illuminate the complex biological mechanisms that trigger cellular processes and molecular functions in infection and diseases. Moreover, Lipps [ 23 ] underlined that there is no in vitro test that can recognize all types of toxins collectively, whereas animal bioassays recognize toxicity from all types of bacterial toxins. Several animal models have been proposed to enhance the virulence of Campylobacter spp.…”
Section: Introductionmentioning
confidence: 99%
“…According to Pore et al [ 22 ], in vivo assays are extremely imperative because they permit researchers to illuminate the complex biological mechanisms that trigger cellular processes and molecular functions in infection and diseases. Moreover, Lipps [ 23 ] underlined that there is no in vitro test that can recognize all types of toxins collectively, whereas animal bioassays recognize toxicity from all types of bacterial toxins. Several animal models have been proposed to enhance the virulence of Campylobacter spp.…”
Section: Introductionmentioning
confidence: 99%