Scorpion (Buthus tamulus) venom toxicity on cardiopulmonary reflexes involves kinins via 5-HT3 receptor subtypes

Bagchi, Sipra; Deshpande, Shripad B.

doi:10.1590/s0104-79302001000100003

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…[5,6] In addition to kinin, PGs are also implicated in venom-induced changes. [6,16] Besides these inflammatory mediators, venom contains histamine, serotonin, and other peptides which produce pain. There is possibility that all these chemical mediators stimulate or excite the vagal receptors or afferents to induce the inhibitory effect on the respiratory center resulting in respiratory failure and death of the animal.…”

Section: Discussionmentioning

confidence: 99%

Role of vagus in mediating the toxicity induced by Mesobuthus tamulus venom in rats

Pandey¹,

Tiwari²,

Deshpande³

2017

Natl J Physiol Pharm Pharmacol

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Background: Mesobuthus tumulus (red scorpion, MBT) envenomation is a serious health problem in tropical countries and is responsible for high morbidity and mortality. Aims and Objectives: Earlier reports about the role of vagus in producing MBT venom-induced toxicity are conflicting. Therefore, in this study, the role of vagus in MBT venom-induced toxicity in rats was evaluated. Materials and Methods: The rats were divided into three groups. In group I, only saline was injected. This group served as control. In group II, MBT venom was injected. In group III, MBT venom was injected in vagotomized rats. Mean arterial pressure (MAP), ECG (for heart rate [HR]), respiratory rate, pulmonary water content, and survival time were determined in all groups. Results: Exposure to MBT venom in rats produced prolonged apnea with intermittent shallow breathing and was accompanied by an instantaneous decrease, followed by an increase and then a progressive decrease in MAP and HR leading to death within 60 min. There was increased pulmonary water content (82% vs. 74% in controls). MBT venom in vagotomized rats produced immediate changes as before, but these changes recovered to reasonably good level within 30 min and the animals survived for >120 min. Pulmonary water content in vagotomized rats was similar to control group. Conclusion: The results indicate that vagus plays a vital role for the toxic effects produced by MBT venom.

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Section: Discussionmentioning

confidence: 99%

Role of vagus in mediating the toxicity induced by Mesobuthus tamulus venom in rats

Pandey¹,

Tiwari²,

Deshpande³

2017

Natl J Physiol Pharm Pharmacol

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“…Sudden stoppage of insulin secretion leads rapidly to hyperglycemia [40]- [42]. The acute hyperglycemia seen in acute myocarditis [8] [37] induced by injection of scorpion venom (Buthus tamulus) could be because of suppression of insulin release from beta cells of the pancreas as well as the capacity for adrenal catecholamines to provoke glycogen breakdown and peripheral inhibition of glucose uptake [32] [37].…”

Section: Adrenalin Inhibits Glucose-induced Secretion Of Insulinmentioning

confidence: 99%

Cardiac Sarcolemmal Defects in Acute Myocarditis Due to Scorpion Envenoming Syndrome

Murthy¹

2014

WJCD

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Death due to scorpion envenoming syndrome is a common event in tropical and subtropical countries. Severe scorpion envenoming causes autonomic storm, massive release of catecholamines, counter-regulatory hormones, suppressed insulin/hyperinsulinemia, acute myocarditis, hyperglycemia, increased free fatty Acid levels, acute pancreatitis, disseminated intra-vascular coagulation, acute pulmonary oedema and death. Severe scorpion envenoming causes cardiac sarcolemmal defects displayed by alterations in Na +-K + ATPase, Mg ++ ATPase and Ca 2+ ATPase activities, inhibition of erythrocyte Na +-K + ATPase activities, hyperkalemia and may result in death. Based on our animal experiments in which insulin administration reversed the metabolic and ECG changes induced by scorpion envenoming and treating the poisonous scorpion sting victims with insulin, we consider that insulin has a primary metabolic role in preventing and reversing acute myocarditis, the cardiovascular, haemodynamic, and neurological manifestations and pulmonary oedema induced by scorpion envenoming. Administration of insulin-glucose infusion to scorpion sting victims appears to be the physiological basis for the control of the metabolic response when that has become a determinant to survival. Continuous infusion of regular crystalline insulin should be given at the rate of 0.3 U/g glucose and glucose at the rate of 0.1 g/kg body weight/hour, for 48-72 hours, with supplementation of potassium as needed and maintenance of fluid, electrolytes and acid-base balance. The observation of cardiac sarcolemmal defects and physiological basis of various patho-physiological mechanisms involved in the genesis of scorpion envenoming syndrome and its reversal (in the experimental animals and scorpion sting victims) by administration of insulin are reviewed.

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Mechanisms underlying the augmentation of phenylbiguanide and capsaicin induced cardiorespiratory reflexes by Mesobuthus tamulus venom

Dutta

Akella

Deshpande

2012

Pulmonary Pharmacology & Therapeutics

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Scorpion (Buthus tamulus) venom toxicity on cardiopulmonary reflexes involves kinins via 5-HT3 receptor subtypes

Cited by 5 publications

References 14 publications

Role of vagus in mediating the toxicity induced by Mesobuthus tamulus venom in rats

Role of vagus in mediating the toxicity induced by Mesobuthus tamulus venom in rats

Cardiac Sarcolemmal Defects in Acute Myocarditis Due to Scorpion Envenoming Syndrome

Mechanisms underlying the augmentation of phenylbiguanide and capsaicin induced cardiorespiratory reflexes by Mesobuthus tamulus venom

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