Histopathological changes in albino mouse testis induced by the administration of Tityus n. sp. venom

Penna-Videau, Salvador; Cermeño-Vivas, J. R; Moreno-Marval, M.; Quiroga-Notti, M.

doi:10.1590/s0104-79302000000200003

Cited by 4 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The causes for the degenerative condition may vary from external exposures (physical, chemical and biological) to genetic predispositions. These include exposure to heat (Kheradmand, Dezfoulian, & Tarrahi, 2011), cold, radiation, venom (Penna‐Videau, Cermeno‐Vivas, Moreno‐Marval, & Quiroga‐Notti, 2000), nutritional deficiency (Sood et al., 1992), ageing (Tanemura, Kurohmaru, Kuramoto, & Hayashi, 1993) and infection (Puggioni et al., 2018) among others. It is possible to reverse those caused by temporary exposures and restore testicular function (e.g., spermatogenesis, hormone production) by removing the external causes (Barth, 2015).…”

Section: Introductionmentioning

confidence: 99%

A novel testicular degenerative condition in a wild population of the common carp Cyprinus carpio (L)

Mahmud

Purser

Patil

2020

Journal of Fish Diseases

View full text Add to dashboard Cite

Gonad abnormalities can restrict or completely block reproductive capability of individuals and in some case that of their populations. Here, we describe a novel testicular degenerative condition of non‐germ cell origin with a high prevalence (up to 22.1% of the population) in a wild population of carp. Based on gross morphology, and microscopic and cellular examinations, the condition shows progressive severity which could be categorized into low, mild, severe and complete. In early stages of the condition, an abnormally increased proliferation (11‐fold) of the Sertoli cell occurred, followed by degenerative cell death of all testicular cells, resulting in fluid‐filled vesicles in the later stages. This initial uncontrolled proliferation of Sertoli cells suggests that the condition could be triggered by malignant pathways; however, the observed subsequent apoptosis of all testicular cells en masse, rendering the animals “sterile,” appears unique. Observations, to date, indicate that this condition is specific to male carp and not present in other species of fish sharing the habitat. High prevalence of the condition allowed comparative evaluation between affected individuals, an aspect likely to facilitate future studies, including elucidation of the cause, robust testing of therapies and practical applications such as management of feral carp populations.

show abstract