PHOSPHOLIPASE A2 FROM Lachesis muta (BUSHMASTER) SNAKE VENOM:BIOCHEMICAL CHARACTERIZATION AND EFFECTS ON PLATELET AGGREGATION

Fuly, André Lopes; Machado, Olga Lima Tavares; Alves, Elias W.; Carlini, Celia Regina Ribeiro da Silva

doi:10.1590/s0104-79301997000200023

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DISCUSSIONS: Phospholipase A2 is the enzyme which helps to cleave the phospholipid of the glycerol backbone 7 . These enzymes induce wide range of pharmacological activity including neurotoxic, cardiotoxic, myotoxic, anticoagulant and hemorrhagic effects 8 . PLA2 are probably the most thoroughly investigated toxins both in hemotoxic and presynaptic neurotoxic snake venom 9 .…”

Section: Fig 20: Secondary Protein Structure Prediction Of Varanusscmentioning

confidence: 99%

Untitled

2015

IJPSR

View full text Add to dashboard Cite

Phospholipase A2 is the enzyme that catalyzes the hydrolysis of the sn-2 fatty acyl bond of phospholipids, liberating free fatty acids and lysophospholipids. These enzymes are found in mammalian tissues, insects, reptiles, urochordates, invertebrates and echinoderms. Some of the PLA2 are toxic in nature. Venom from snakes and insects is largely composed of melittin, which is a stimulant of PLA2. In this study, Phylogenetic relationship of Phospholipase A2 were compared, tertiary &secondary structures of PLA2 in different species like Apismellifera, Najaatra, Varanusscalaris, Asterinapectinifera, Mesobuthustumulus, Rophilemanomadica were predicted. INTRODUCTION: Phospholipase A2 is commonly found in mammalian tissues as well as in insects, reptiles, urochordates, invertebrates and echinoderms. Venom from both snakes and insects is largely composed of melittin, which is a stimulant of PLA2. Due to the increased presence and activity of PLA2 resulting from a snake or insect bite, arachidonic acid is released from the phospholipid membrane disproportionately. As a result, inflammation and pain occur at the site. The venom of the bee has a very complex mixture of active peptides, enzymes and amines. The Major components of the bee venom are melittin, histamine and phospholipase A2. The effects of bee venom on humoral and cellular immune responses have been tested in different reports.

show abstract

Section: Fig 20: Secondary Protein Structure Prediction Of Varanusscmentioning

confidence: 99%