BIOCHEMICAL CHARACTERIZATION OF THE VENOM OF THE SOCIAL WASP Agelaia pallipes pallipes (HYMENOPTERA - VESPIDAE)

Costa, Henrique Olival

doi:10.1590/s0104-79301997000100008

Cited by 2 publications

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“…Commonly, such peptides consist of single chain molecules with molecular weight ranging from 3 to 10 kDa, rich in cysteine residues, forming disulfide bonds. This ICK-like peptide is described as a minor component in Dinoponera quadriceps venom, but shows a VI/VII cysteine framework (-C-C-CC-C-C-) consistent with other ICK toxins (Aili et al, 2014;Torres et al, 2014) reported in spider and cone snail venoms, normally exhibiting neurotoxic properties (Craik et al, 2001;Herzig and King, 2015).…”

Section: Uncharacterized Peptidessupporting

confidence: 79%

Diversity of peptidic and proteinaceous toxins from social Hymenoptera venoms

Santos-Pinto

Pérez-Riverol

Lasa

et al. 2018

Toxicon

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Among venomous animals, Hymenoptera have been suggested as a rich source of natural toxins. Due to their broad ecological diversity, venom from Hymenoptera insects (bees, wasps and ants) have evolved differentially thus widening the types and biological functions of their components. To date, insect toxinology analysis have scarcely uncovered the complex composition of bee, wasp and ant venoms which include low molecular weight compounds, highly abundant peptides and proteins, including several allergens. In Hymenoptera, these complex mixtures of toxins represent a potent arsenal of biological weapons that are used for self-defense, to repel intruders and to capture prey. Consequently, Hymenoptera venom components have a broad range of pharmacological targets and have been extensively studied, as promising sources of new drugs and biopesticides. In addition, the identification and molecular characterization of Hymenoptera venom allergens have allowed for the rational design of component-resolved diagnosis of allergy, finally improving the outcome of venom immunotherapy (VIT). Until recently, a limited number of Hymenoptera venoms had been unveiled due to the technical limitations of the approaches used to date. Nevertheless, the application of novel techniques with high dynamic range has significantly increased the number of identified peptidic and proteinaceous toxins. Considering this, the present review summarizes the current knowledge about the most representative Hymenoptera venom peptides and proteins which are under study for a better understanding of the insect-caused envenoming process and the development of new drugs and biopesticides.

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Section: Uncharacterized Peptidessupporting

confidence: 79%

Diversity of peptidic and proteinaceous toxins from social Hymenoptera venoms

Santos-Pinto

Pérez-Riverol

Lasa

et al. 2018

Toxicon

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Mosquito Repellent Activity of the Methanol Extracts of Some Ascidian Species

Hussein¹,

Jantan²,

Awaludin³

et al. 2002

Pharmaceutical Biology

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The methanol extracts of seven marine ascidian species (Clavelina picta, Eudistoma obscuratum, Atriolum robustum, Didemnum sp., D. molle, Phallusia sp. and Aplidium sp.) from Malaysia were investigated for their repellency effects against four vector mosquitoes (Anopheles maculatus, Aedes aegypti, Ae. albopictus and Culex quinquefasciatus). Mosquito repellent activity was assessed by using the test cage described in the American Society for Testing and Materials standard E951-83. The extracts showed a significant degree of repellency against the mosquitoes with ED 50 values ranging from 0.0008 to 0.0746 mg cm -2 . The repellency effects were dose-dependent and selective as the ED 50 values showed variation towards the various mosquitoes. Amongst these, the extract of Didemnum sp., with an ED 50 of 0.0008 mg cm -2 against An. maculatus, was the most effective, comparable to the value obtained with the standard repellent, deet.Pharmaceutical Biology Downloaded from informahealthcare.com by McMaster University on 11/18/14For personal use only.

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BIOCHEMICAL CHARACTERIZATION OF THE VENOM OF THE SOCIAL WASP Agelaia pallipes pallipes (HYMENOPTERA - VESPIDAE)

Cited by 2 publications

References 0 publications

Diversity of peptidic and proteinaceous toxins from social Hymenoptera venoms

Diversity of peptidic and proteinaceous toxins from social Hymenoptera venoms

Mosquito Repellent Activity of the Methanol Extracts of Some Ascidian Species

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