Solubility improvement of an anthelmintic benzimidazole carbamate by association with dendrimers

Fernández, Luciana; Sigal, E.; Otero, Luís; Silber, Juana J.; Santo, Marisa

doi:10.1590/s0104-66322011000400013

Cited by 18 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fernández et al used ethylenediamine core PAMAM dendrimers in an attempt to improve the aqueous solubility of ABZ. G3 PAMAM dendrimers (-NH 2 terminated, –OH terminated) and carboxylate terminal 0.5G, 2.5G, and 3.5G PAMAM dendrimers, were used for investigating their effect on solubilization of ABZ (Fernández et al, 2011 ). Studies suggest that the mechanism behind the solubilizing effect of dendrimers on ABZ could be ionic interactions, hydrophobic drug-dendrimer interactions and hydrogen bonding (Gupta et al, 2006b ).…”

Section: Solubilization Of Existing Drugsmentioning

confidence: 99%

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules

et al. 2017

View full text Add to dashboard Cite

Adequate aqueous solubility has been one of the desired properties while selecting drug molecules and other bio-actives for product development. Often solubility of a drug determines its pharmaceutical and therapeutic performance. Majority of newly synthesized drug molecules fail or are rejected during the early phases of drug discovery and development due to their limited solubility. Sufficient permeability, aqueous solubility and physicochemical stability of the drug are important for achieving adequate bioavailability and therapeutic outcome. A number of different approaches including co-solvency, micellar solubilization, micronization, pH adjustment, chemical modification, and solid dispersion have been explored toward improving the solubility of various poorly aqueous-soluble drugs. Dendrimers, a new class of polymers, possess great potential for drug solubility improvement, by virtue of their unique properties. These hyper-branched, mono-dispersed molecules have the distinct ability to bind the drug molecules on periphery as well as to encapsulate these molecules within the dendritic structure. There are numerous reported studies which have successfully used dendrimers to enhance the solubilization of poorly soluble drugs. These promising outcomes have encouraged the researchers to design, synthesize, and evaluate various dendritic polymers for their use in drug delivery and product development. This review will discuss the aspects and role of dendrimers in the solubility enhancement of poorly soluble drugs. The review will also highlight the important and relevant properties of dendrimers which contribute toward drug solubilization. Finally, hydrophobic drugs which have been explored for dendrimer assisted solubilization, and the current marketing status of dendrimers will be discussed.

show abstract

Section: Solubilization Of Existing Drugsmentioning

confidence: 99%

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules

et al. 2017

View full text Add to dashboard Cite

show abstract

“…amine group on the aromatic ring. Based on these data it was suggested that ABZ can participate in both inter-and intramolecular hydrogen bonding and that the contribution of the different structures will depend on the interactions of ABZ with its environment (Fernández, Sigal, Otero, Silber, & Santo, 2011).…”

Section: Introductionmentioning

confidence: 99%

13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes

Ferreira

Garcı́a

Leonardi

et al. 2015

Carbohydrate Polymers

View full text Add to dashboard Cite

“…It had been settled that every particular component bonds related to lipophilic connections cause an improvement inside the solvency of ABZ. The change in dissolvability expansion with the dendrimer assortments maybe because of the kind of ABZ-dendrimer associations, figuring superficially helpful groups of dendrimers 46 .…”

Section: Fig 5: Factors Affecting Dendrimer-mediated Drug Solubilizamentioning

confidence: 99%

Untitled

2020

IJPSR

View full text Add to dashboard Cite

Sufficient fluid solvency has been one in everything about required properties while choosing drug particles and completely uncommon bio-actives for advancement. Here and there dissolvability of a medication decides its pharmaceutical and remedial execution. Most of these days organized medicine IOTAS miss the mark or are rejected for the length of the main times of drug disclosure and improvement on account of the truth of their obliged dissolvability. Test consistency, liquid dissolvability, and manufactured equality of the prescription are central for touching base at enough bioavailability and supportive outcome. Dendrimers, an alternate class of polymers, have the decent potential for medication solvency improvement, by temperance of their unmistakable properties. These hyper-stretched, mono-scattered particles have the particular capacity to tie the medication atoms on fringe still to typify these particles among the fiber structure. There are differed reportable investigations that have effectively utilized dendrimers to flavor up the solubilization of inadequately solvent prescription. These promising results have intrigued the analysts to vogue, orchestrate, and evaluate fluctuated fiber polymers for his or her utilization in medication conveyance and product improvement. This survey will talk about the perspectives and the job of dendrimers at interims the solvency improving the ineffectively solvent drug. This survey can feature the significant and important properties of dendrimers that contribute to medication solubilization. At last, hydrophobic medicine that is investigated for dendrimer helped solubilization, and subsequently, this advancing remaining of dendrimers are referenced here. INTRODUCTION: The significance of the new polymers utilized for the medication in Programming interface conveyance into the life structures, some way or another it's horribly hard to initiate all Programming interface of medication solubilized in our life systems that is the reason researchers have built up a fresh out of the box new class synthetic exacerbate that is comprehended as Dendrimers.

show abstract

Solubility improvement of an anthelmintic benzimidazole carbamate by association with dendrimers

Cited by 18 publications

References 28 publications

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules

13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes

Untitled

Contact Info

Product

Resources

About