Ca alginate as scaffold for iron oxide nanoparticles synthesis

Abstract

-Recently, nanotechnology has developed to a stage that makes it possible to process magnetic nanoparticles for the site-specific delivery of drugs. To this end, it has been proposed as biomaterial for drug delivery system in which the drug release rates would be activated by a magnetic external stimuli. Alginate has been used extensively in the food, pharmaceutical and biomedical industries for their gel forming properties in the presence of multivalent cations. In this study, we produced iron oxide nanoparticles by coprecipitation of Fe(III) and Fe(II). The nanoparticles were entrapped in Ca alginate beads before and after alginate gelation. XRD analysis showed that particles should be associated to magnetite or maghemite with crystal size of 9.5 and 4.3 nm, respectively. Studies using Mössbauer spectroscopy corroborate the superparamagnetic behavior. The combination of magnetic properties and the biocompatibility of alginate suggest that this biomaterial may be used as biomimetic system.

Magnetite nanoparticles for medical MR imaging

“…The two most common methods are co-precipitation 51-53 and thermal decomposition 54,55 . Synthesis of SPIONs by co-precipitation of Fe 2+ and Fe 3+ in aqueous solutions has traditionally been the most utilized synthesis method 56 .…”

A One Pot Green Synthesis and Characterisation of Iron Oxide-Pectin Hybrid Nanocomposite

“…A green synthetic strategy of oxide NPs (including magnetite) where starch was used as the stabilizing agent has been reported [22]. Alginates have been reported to act as a scaffold for the synthesis of magnetite NPs [23]. A modified chitosan (chitosan-polyacrylic acid) was used to improve the binding on magnetite NPs.…”

Amelioration of H4[W12SiO40] by nanomagnetic heterogenization: For the synthesis of 1H–pyrazolo[1,2‐b]phthalazinedione derivatives

“…The Mossbauer spectrum ( Figure 3) was obtained which confirmed that Fe 3 O 4 had been successfully synthesized [32] with a paramagnetic doublet suggesting its superparamagnetic properties. [33][34][35][36][37] The broadening of the sextet lines reaffirms the superparamagnetic behaviour of the nanoparticles. The fitted parameter of the spectrum, isomer shift of 0.24(1) mm s −1 , is similar to that of magnetite nanoparticles.…”