Selectivity in the extraction of 2- quinolone alkaloids with supercritical CO2

Abstract

-This work describes the conditions for selective extraction of the alkaloids in Andreadoxa flava (Kallunki). The experiments were performed in a pilot plant SFE 500, in the following conditions. Extractor o C in the separators. The samples, extracted from A. flava leaves, were analysed by 1 H NMR and GC/FID as well as by comparison with standards. This procedure allowed the identification for the first time of the 2-quinolone alkaloid 8-methoxy-N-methyl-flindersine in A. flava leaves of the. In addition, zanthophylline, 5-methoxyalmene and 8-methoxyflindersine were identified as the main alkaloids in leaves. Under the best conditions for zanthophylline extraction it was possible to obtain a purity of 79.4% while with other phytochemical technique 55.5% was obtained.

Extraction of caffeine, chlorogenic acids and lipids from green coffee beans using supercritical carbon dioxide and co-solvents

“…Supercritical CO 2 extraction is among the new emerging clean and environmental friendly technologies for the processing of food and pharmaceutical products (Subramanian et al, 1997;Perrut, 2000). Alkaloids (Santana et al, 2006) and phenolics (Okuno et al, 2002) have been extracted from plants using supercritical CO 2 . However, this technique strongly depends on the solubility of lowvolatile substances in supercritical fluids, usually CO 2 , a non-polar solvent, with low affinity for polar substances.…”