The effect of some processing conditions on the characteristics of biodegradable microspheres obtained by an emulsion solvent evaporation process

Maia, Junot; Santana, M. H. A.; Ré, Maria Inês

doi:10.1590/s0104-66322004000100002

Cited by 71 publications

(62 citation statements)

References 12 publications

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“…Similar morphological data were provided by Maia et al 14 when PHBV microparticles were prepared by single emulsion/ solvent evaporation technique. In some of the obtained formulations, pores were also verified on the microparticles surface (Figure 1, a,b).…”

Section: Characterization Of Microparticlessupporting

confidence: 78%

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Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

Farago¹,

Raffin²,

Pohlmann³

et al. 2008

J. Braz. Chem. Soc.

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Micropartículas de poli(3-hidroxibutirato-co-3-hidroxivalerato) (PHBV) contendo um fármaco modelo hidrofílico, o cloridrato de metformina (MH), foram obtidas pela técnica de emulsão múltipla/evaporação do solvente. Diversas formulações foram preparadas, com o objetivo de investigar a influência de cada composição sobre a eficiência de encapsulação (EE). O resultado mais elevado de EE (9,76%) foi verificado quando da simultânea alcalinização e adição de NaCl na fase aquosa externa da formulação. O estudo por MEV das micropartículas revelou morfologia esférica e superfície rugosa. As intensidades de difração cristalina para as micropartículas contendo o MH foram menores do que aquelas observadas para a mistura física. Os resultados obtidos por IVTF sugerem que nenhuma ligação química foi formada entre o polímero e o fármaco. A avaliação por análise térmica indica o surgimento de interações favoráveis entre MH e PHBV. O estudo de liberação in vitro demonstrou a influência do PHBV no perfil de dissolução do MH.Poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) microparticles containing a watersoluble model drug, metformin hydrochloride (MH), were obtained by a double emulsion/solvent evaporation technique. Several formulations were prepared in order to investigate the influence of each composition on the encapsulation efficiency (EE). The highest value of EE (9.76%) was obtained using simultaneously pH alkalinization and NaCl addition in the external water phase of the formulation. SEM study revealed a spherical morphology and a rough surface. The crystalline diffraction intensities for the MH-loaded microparticles were lower than that verified for the physical mixture. FTIR results suggested that no chemical bond between the polymer and the drug was formed. Also thermal analyses indicated a favorable interaction between MH and PHBV. In vitro drug release demonstrated the influence of the PHBV on the dissolution profile of MH. Keywords: PHBV, double emulsion/solvent evaporation technique, hydrophilic model drug, microparticles IntroductionBiodegradable polymeric materials have been received increasing interest due to several ecological and recycling aspects. 1,2 Among numerous microbial polyesters, poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) has been widely investigated as a biocompatible material suitable for pharmaceutical and medical applications. The literature reports the use of PHBV in tissue engineering and as drug delivery systems. [3][4][5][6][7][8][9][10][11][12] Particularly, PHBV exhibits unique and interesting physicochemical features (e.g. piezoelectricity) in addition to their mechanical properties similar to the polypropylene and other widely used polyesters [e.g. poly(DL-lactide) and poly(DL-lactide-co-glycolide)]. 13 Moreover, PHBV is a less crystalline biopolymer than poly(3-hydroxybutirate), therefore an enhanced degradation rate is observed. 14 Farago et al. 1299 Vol. 19, No. 7, 2008 Several methods have been used to prepare microparticles, for both natural and synthetic polymers. 15...

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Section: Characterization Of Microparticlessupporting

confidence: 78%

“…13 Moreover, PHBV is a less crystalline biopolymer than poly(3-hydroxybutirate), therefore an enhanced degradation rate is observed. 14 Vol. 19, No.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

Farago¹,

Raffin²,

Pohlmann³

et al. 2008

J. Braz. Chem. Soc.

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“…There was a significant difference in particle size on primary homogenization time but no effect was observed of secondary homogenization time on particle size. Formulation F3 B5 was chosen for further characterization of doxorubicin liposomes 12,13,14,15 Percent free drug The percent free drug was determined for optimized formulation F3 B5 . The percent free drug for F3 B5 formulation was obtained 8.62%.…”

Section: Optimization Of Process and Formulation Variables For Doxorumentioning

confidence: 99%

Formulation and Characterization of Doxorubicin Hydrochloride Liposomes by Double Emulsion Method

Maheshkumar¹,

Reddy²,

Goud³

et al. 2016

Int. Res. J. Pharm.

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Doxorubicin hydrochloride is one of the most commonly used cytotoxic anthracycline antibiotics used in cancer chemotherapy and has been shown to have activity against a wide variety of neoplasms. Conventional compositions of doxorubicin hydrochloride are available as freeze-dried product (or) as a solution of doxorubicin hydrochloride in water. Both these products have been associated with a number of toxicities when administered intravenously. Several approaches have taken in an effort to increase the circulation time of liposomes by coating the liposomal surface with a hydrophilic polymer such as polyethylene glycol, but have new toxic effects appeared like skin toxicity generally known as "Hand-Foot Syndrome". In the present study Doxorubicin Liposomes were formulated by "Double emulsion method to form Multivescicular liposomes". The influence of various formulation and process parameters using different ratios of inner aqueous phase: oil phase: outer aqueous phase, homogenization speed, homogenization time on encapsulation efficiency, % free drug, particle size, zeta potential, surface morphology and release were investigated. Less than 10 % free drug was achieved with double emulsion method. The Scanning Electron Microscopy image showed the spherical shape having 33 ± 5 µm particle sizes. The in-vitro drug release for optimized formulation was found to be controlled release of drug over a period of 7 days.

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“…Increased surfactant concentration led to the formation of globules with a lower average size and stabilization of the emulsion Tyagi and Kori 281 droplets avoiding their coalescence, resulting in smaller microspheres (Maia et al, 2004). An optimum concentration is required to produce finest stable dispersion.…”

Section: Effect Of Emulsifier Concentration On Particle Size Percentmentioning

confidence: 99%

Development and in-vitro characterization of lornoxicam loaded ethyl cellulose microspheres prepared by emulsion solvent evaporation method

Tyagi¹,

Kori²

2014

Afr. J. Pharm. Pharmacol.

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Advancement in drug delivery could come from innovating improvement to the existing drug delivery system. Lornoxicam (Lxm) loaded ethyl cellulose microspheres were prepared by emulsion solvent evaporation technique and also to investigate the effect of variations in drug concentration, polymer concentration, internal phase volume, continuous phase volume and emulsifier concentration on the particle size, shape, % yield, percent entrapment efficiency and in vitro drug release behavior. The scanning electron microscopy (SEM) revealed that microspheres had good spherical geometry with smooth surface. The result showed that the maximum yield of the microspheres was found to be 64.23 ± 0.25%, with particle size in the range of 64.24 ± 1.82 to 81.83 ± 3.43 μm and encapsulation efficiency was found to be in a range of 60.34 ± 1.63 to 71.61 ± 1.20%. The average particle size and entrapment efficiency of microspheres were enhanced with increasing polymer concentration but reduced with increasing internal phase volume, external phase volume and emulsifier concentration. In vitro release profile of microspheres was in the range of 75.65 ± 2.3 to 87.78 ± 2.3% at the end of 12 h. It was concluded that Lxm loaded ethyl cellulose microspheres formulation showed sustained effect over a period of 12 h.

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The effect of some processing conditions on the characteristics of biodegradable microspheres obtained by an emulsion solvent evaporation process

Cited by 71 publications

References 12 publications

Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

Formulation and Characterization of Doxorubicin Hydrochloride Liposomes by Double Emulsion Method

Development and in-vitro characterization of lornoxicam loaded ethyl cellulose microspheres prepared by emulsion solvent evaporation method

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