Phenomenological model of the clavulanic acid production process utilizing Streptomyces clavuligerus

Neto, Álvaro de Baptista; Gouveia, Ester Ribeiro; Badino-Jr, A.C.; Hokka, Carlos O.

doi:10.1590/s0104-66322000000400043

Cited by 10 publications

(9 citation statements)

References 17 publications

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“…The production rate remained almost constant up to 60 h, ca 32 h after glycerol consumption had been completed. Also cell growth occurred in approximately 27 h. This fact indicates that production of clavulanic acid is not associated with microorganism growth, in agreement with the results obtained by Baptista Neto et al (2000).…”

Section: Resultssupporting

confidence: 91%

A study on clavulanic acid production by Streptomyces clavuligerus in batch, fed-batch and continuous processes

Neto

Hirata

Filho

et al. 2005

Braz. J. Chem. Eng.

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-Clavulanic acid (CA) is a potent inhibitor of β-lactamases, enzymes that are responsible for the hydrolysis of β-lactam antibiotics. It is a secondary metabolite produced by the filamentous aerobic bacterium Streptomyces clavuligerus in submerged cultivations. In the present work clavulanic acid production in batch, fed-batch and continuous bioreactors was studied with the objective of increasing productivity. The operating conditions: temperature, aeration and agitation, were the same in all cases, 28º C, 0.5 vvm and 800 rpm, h -1 in the fed-batch process and 3.5 mg L -1 h -1 in the batch process, suggesting that continuous culture of Streptomyces clavuligerus is a promising strategy for clavulanic acid production.

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Section: Resultssupporting

confidence: 91%

A study on clavulanic acid production by Streptomyces clavuligerus in batch, fed-batch and continuous processes

Neto

Hirata

Filho

et al. 2005

Braz. J. Chem. Eng.

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“…Kinetic parameters are essential not only to estimate the cost of a bioprocess but also to develop control strategies (Baptista-Neto et al 2000). In this way, some kinetic parameters, specifically BC productivity (P BC ) and yield of substrate on product (Y P/S ), were investigated, and the results are shown in Fig.…”

Section: Kinetic Studymentioning

confidence: 99%

Bacterial cellulose production by Gluconacetobacter xylinus by employing alternative culture media

Jozala

Pértile

Santos

et al. 2014

Appl Microbiol Biotechnol

151

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Bacterial cellulose (BC) is used in different fields as a biological material due to its unique properties. Despite there being many BC applications, there still remain many problems associated with bioprocess technology, such as increasing productivity and decreasing production cost. New technologies that use waste from the food industry as raw materials for culture media promote economic advantages because they reduce environmental pollution and stimulate new research for science sustainability. For this reason, BC production requires optimized conditions to increase its application. The main objective of this study was to evaluate BC production by Gluconacetobacter xylinus using industry waste, namely, rotten fruits and milk whey, as culture media. Furthermore, the structure of BC produced at different conditions was also determined. The culture media employed in this study were composed of rotten fruit collected from the disposal of free markets, milk whey from a local industrial disposal, and their combination, and Hestrin and Schramm media was used as standard culture media. Although all culture media studied produced BC, the highest BC yield-60 mg/mL-was achieved with the rotten fruit culture. Thus, the results showed that rotten fruit can be used for BC production. This culture media can be considered as a profitable alternative to generate high-value products. In addition, it combines environmental concern with sustainable processes that can promote also the reduction of production cost.

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“…This case study concerns the bioprocess described by Baptista-Neto et al (2000) for clavulanic acid production. Table 3 presents the experimental values of cultivation conditions and kinetic parameters estimated by the authors using a non-linear regression method (Marquardt algorithm) with 95% confidence level.…”

Section: Parameter Estimation Using Optimusferm (Case Study 1)mentioning

confidence: 99%

“…Fig. 5 shows a window with the experimental substrate, biomass, and product concentration data, as a function of time, as presented by Baptista-Neto et al (2000). In this example, only one experimental data set was used, but it is possible to input additional data sets.…”

Section: Cultivation Equationmentioning

confidence: 99%

AnaBioPlus: a new package for parameter estimation and simulation of bioprocesses

Oliveira

Jesus

Ceneviva

et al. 2017

Braz. J. Chem. Eng.

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A very important step in the study of bioprocesses is the modeling and simulation of bioreactors. This paper presents the AnaBioPlus software package, which was developed for teaching and research purposes concerning the analysis of bioreactors. The package consists of two programs: OptimusFerm and SimulaFerm. OptimusFerm allows the analysis of experimental batch cultivation data sets in order to estimate parameters of kinetic models by means of a differential evolution method. SimulaFerm performs simulations obtaining values of cell growth, product formation, and limiting substrate consumption for batch, fed-batch and continuous cultivations. Thirty-two kinetic models of cell growth are available in OptimusFerm and SimulaFerm. Two case studies are described in order to illustrate the use of AnaBioPlus. The results show that AnaBioPlus is a very useful tool for the analysis of bioprocesses. Furthermore, it presents a user-friendly graphical interface and is freely available to users, in both English and Portuguese versions.

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Phenomenological model of the clavulanic acid production process utilizing Streptomyces clavuligerus

Cited by 10 publications

References 17 publications

A study on clavulanic acid production by Streptomyces clavuligerus in batch, fed-batch and continuous processes

A study on clavulanic acid production by Streptomyces clavuligerus in batch, fed-batch and continuous processes

Bacterial cellulose production by Gluconacetobacter xylinus by employing alternative culture media

AnaBioPlus: a new package for parameter estimation and simulation of bioprocesses

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