Defectos del tubo neural y del ácido fólico: recorrido histórico de una intervención preventiva altamente efectiva

Vásquez, Adriana Ordóñez; Süárez-Obando, Fernando

doi:10.1590/s0104-59702015005000002

Cited by 5 publications

(2 citation statements)

References 74 publications

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“…The vitamin exists extensively in fresh fruits, leafy vegetables, and meat products. A deficiency in FA leads to nerve system damage, irritability, megaloblastic anemia, diarrhea, and psychiatric disorders (Chang et al, 2015;Liu et al, 2015;Srivastav, Singh, Yadav, & Srikrishna, 2015;Vasquez & Suarez-Obando, 2015). In pregnant women, FA deficiency results in neural tube defects, developmental retardation, and early spontaneous abortion (Barco Tavares, Neves Finochio Sabino, Lima, & Tozzo Garcia, 2015;Leuckx, 2015;Smithells, Sheppard, & Schorah, 1976).…”

Section: Introductionmentioning

confidence: 99%

Development of ic-ELISA and lateral-flow immunochromatographic assay strip for the detection of folic acid in energy drinks and milk samples

Kong

Liu

Song

et al. 2016

Food and Agricultural Immunology

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Folic acid (FA) is an important vitamin for human growth and development, especially for pregnant women. A sensitive, rapid, and accurate FA detection method is required to assess the nutritional quality and safety of foods. A monoclonal antibody against FA was prepared for the development of indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) and lateral-flow immunochromatographic assay (ICA) strip. The 50% inhibitory concentration and limit of detection of ic-ELISA were 0.12 and 0.018 ng/ml, respectively. The visual limit of detection and cut-off values of the lateral-flow ICA strip were 0.5 and 2.5 ng/ ml, respectively. Using the ICA strip, FA recovery rates were 89-98% from energy drinks and 73-87% for milk samples and were in good agreement with those obtained from the conventional microbiological assay method. Our developed methods are sensitive, convenient, effective, and suitable for on-site detection and rapid mass screening of food samples. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Development of ic-ELISA and lateral-flow immunochromatographic assay strip for the detection of folic acid in energy drinks and milk samples

Kong

Liu

Song

et al. 2016

Food and Agricultural Immunology

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“…Em 1941, os pesquisadores Mitchell Snell e Williams isolaram folatos de folha de espinafre assim surgindo à denominação para a vitamina. Esta vitamina foi sintetizada na forma cristalina em 1943 por Bob Stokstad, e em 1945 por Angier (Vásquez & Suarez-Obando, 2015). As moléculas de folatos são tripartidas compreendendo em um anel pteridinio, pelos ácidos paraaminobenzóico (pABA) e glutâmico (Quinlivan et al, 2003) (Figura 1).…”

Section: Folatosunclassified

Variação natural de folato em sementes de feijão-caupi [Vigna unguiculata (L.) Walp.] e sua correlação com a expressão do gene Vugch1 (GTP ciclohydrolase 1)

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Valores séricos de ácido fólico en un grupo de pacientes mayores de 18 años de edad en un hospital de alta complejidad

et al. 2017

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ResumenObjetivo: establecer las concentraciones séricas de ácido fólico en un grupo de pacientes adultos. Métodos: medición del ácido fólico con inmunoanálisis en 1797 sujetos. Se calcularon medidas de tendencia central e índice de confianza al 95 %. Se compararon grupos etarios y sexos con pruebas no paramétricas. Resultados: la media global de ácido fólico sérico fue: 11,61 ng/ml (DE: 6,05). La media en mujeres fue de 11,87 ng/ml (DE: 6,09). La media en hombres fue de 11,31 ng/ml (DE: 6). Se reportaron los percentiles 5, 50 y 95 por sexo y edad. En el 2 % de los casos se encontró ácido fólico < 2 ng/ml (2 % de hombres y 3 % de mujeres). Discusión: las concentraciones séricas de ácido fólico son mayores en mujeres que en hombres (p = 0,024), lo que contrasta con la noción de déficit del micronutriente en el sexo femenino. Conclusiones: las cantidades descritas son un comparador adecuado para mediciones en muestras de población general.

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Defectos del tubo neural y del ácido fólico: recorrido histórico de una intervención preventiva altamente efectiva

Abstract: This article gives a broad overview of part of the historical evolution of medical knowledge about neural tube defects (NTD)

Cited by 5 publications

References 74 publications

Development of ic-ELISA and lateral-flow immunochromatographic assay strip for the detection of folic acid in energy drinks and milk samples

Development of ic-ELISA and lateral-flow immunochromatographic assay strip for the detection of folic acid in energy drinks and milk samples

Variação natural de folato em sementes de feijão-caupi [Vigna unguiculata (L.) Walp.] e sua correlação com a expressão do gene Vugch1 (GTP ciclohydrolase 1)

Valores séricos de ácido fólico en un grupo de pacientes mayores de 18 años de edad en un hospital de alta complejidad

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