Análise dos resultados maternos e fetais dos procedimentos invasivos genéticos fetais: um estudo exploratório em Hospital Universitário

Abstract

713 procedures were performed (113 CVS, 340 amniocenteses, and 260 cordocenteses). The main indication for performing invasive procedures was the presence of structural changes in fetuses, followed by increased values of nuchal translucency, and advanced maternal age. Fetal karyotype was altered in 186 cases (26.1%). The 18 trisomy was the commonest aneuploidy followed by the 21 trisomy, X monosomy, and 13 trisomy. There were 4.9% cases of miscarriage, 25.7% cases of stillborn infants, and 13% cases of neonatal deaths. Eight pregnant women opted for legally induced abortion. 99% of pregnant women whose fetuses did not present abnormalities and presented normal fetal karyotype had infants who were born alive.

Cordocentesis

“…Before 24 weeks of gestation, fetal loss within 2 weeks of the procedure was 2.7 % as compared to 1 %, while after 24 weeks, the total and procedure-related risk of loss was 1.9 and 0.8 %, respectively [15]. Of the patients who underwent cordocentesis in the presence of structural abnormalities, the presence of stillbirth has been observed in up to 24.6 % of cases [16]. Hence, fetal loss due to complications after cordocentesis is in the range of 1.3 % of the normal fetuses and up to 25 % in fetus with congenital abnormalities [17].…”